主 办:北 京 中 医 药 大 学
ISSN 2095-6606 CN 10-1157/R

现代中医临床 ›› 2020, Vol. 27 ›› Issue (3): 33-40.doi: 10.3969/j.issn.2095-6606.2020.03.008

• 文献研究 • 上一篇    下一篇

桂枝茯苓胶囊联合左炔诺孕酮宫内节育系统治疗子宫腺肌病临床疗效的Meta分析

刘子康1, 孙伟伟2, 赵瑞华2#   

  1. 1 北京中医药大学 北京 100029;
    2 中国中医科学院广安门医院
  • 收稿日期:2019-11-13 发布日期:2020-06-09
  • 通讯作者: #赵瑞华,女,博士,主任医师,博士生导师,E-mail:rhzh801@126.com
  • 作者简介:刘子康,女,在读硕士生

Efficacy of Guizhi Fuling Capsule combined with Levonorgestrel Intrauterine System in the treatment of adenomyosis:a meta-analysis

Liu Zikang1, Sun Weiwei2, Zhao Ruihua2#   

  1. 1 Beijing University of Chinese Medicine, Beijing 100029;
    2 Guang’anmen Hospital, China Academy of Chinese Medical Sciences
  • Received:2019-11-13 Published:2020-06-09

摘要: 目的 系统评价桂枝茯苓胶囊联合左炔诺孕酮宫内节育系统(LNG-IUS)治疗子宫腺肌病(adenomyosis AM)的临床疗效。方法 计算机检索中国知网(CNKI)、万方数据库、维普数据库(VIP)、PubMed、Cochranelibrary、Embase数据库,检索年限为建库至2019年4月26日。收集关于桂枝茯苓胶囊联合LNG-IUS治疗AM的随机对照试验(randomized control trial,RCT)。采用Revman 5.3软件进行Meta分析。结果 共纳入文献9篇,共982例患者,Meta分析结果显示:与单纯LNG-IUS组相比,桂枝茯苓胶囊联合LNG-IUS组的总有效率明显提高(RR=1.23,95%CI:[1.15,1.33]),并可有效地减少月经量(SMD=-0.87,95%CI:[-1.52,-0.22])、减轻痛经程度(SMD=-1.52,95%CI:[-2.11,-0.94])、降低子宫内膜厚度(SMD=-1.24,95%CI:[-1.40,-1.07])、缩小子宫体积(SMD=-0.79,95%CI:[-1.04,-0.55]),降低血清CA125(SMD=-0.77,95%CI:[-1.07,-0.47])、血清FSH(SMD=-1.09,95%CI:[-1.27,-0.92])、血清LH(SMD=-0.85,95%CI:[-1.03,-0.66])水平,升高血清E2(SMD=1.10,95%CI:[0.93,1.28])水平,桂枝茯苓胶囊联合LNG-IUS与单纯LNG-IUS在不良反应方面差异无统计学意义(RR=0.82,95%CI:[0.67,1.01])。结论 与单纯LNG-IUS相比,桂枝茯苓胶囊联合LNG-IUS治疗AM在总有效率、改善月经量、减轻痛经、降低子宫内膜厚度、缩小子宫体积、降低血清CA125及改善体内激素水平方面疗效确切,且不会增加不良反应的风险。

关键词: 桂枝茯苓胶囊, 左炔诺孕酮宫内节育系统, 子宫腺肌病, Meta分析

Abstract: Objective To systematically evaluate the clinical efficacy of Guizhi Fuling Capsule combined with Levonorgestrel Intrauterine System(LNG-IUS) in the treatment of adenomyosis. Methods The databases of CNKI,Wanfang,VIP,PubMed,Cochrane and Embase were electronically searched.The search period was from the database construction time until April 26, 2019. Meta-analysis was performed by using Revman 5.3 software. Results A total of 9 articles and 982 patients were included.The results showed that,as compared with the simple LNG-IUS group, Guizhi Fuling Capsule combined with LNG-IUS group significantly improved the total effective rate(RR=1.23,95%CI:[1.15,1.33]),and most significantly reduced menstrual flow (SMD=-0.87,95%CI:[-1.52,-0.22]),relieved dysmenorrhea (SMD=-1.52,95%CI:[-2.11,-0.94]),reduced endometrial thickness(SMD=-1.24,95%CI:[-1.40,-1.07]), decreased uterine volume (SMD=-0.79,95%CI:[-1.04,-0.55]),significantly reduced serum CA125 (SMD=-0.77,95%CI:[-1.07,-0.47]), serum FSH (SMD=-1.09,95%CI:[-1.27,-0.92]),LH(SMD=-0.85,95%CI:[-1.03,-0.66]) level, and increased serum E2 (SMD=1.10,95%CI:[0.93,1.28]),Guizhi Fuling Capsule combined with LNG-IUS and simple LNG-IUS alone had no significant difference in adverse reactions (RR=0.82,95%CI:[0.67,1.01]). Conclusions As compared with LNG-IUS alone,Guizhi Fuling Capsule combined with LNG-IUS has definite effects in the treatment of AM in terms of total effective rate,menstrual flow,degree of dysmenorrhea,endometrial thickness,uterine volume,serum CA125,hormone levels in the body and it does not increase the risk of adverse reactions.

Key words: Guizhi Fuling Capsule, levonorgestrel intrauterine system, adenomyosis, meta-analysis

中图分类号: 

  • R271.9