主 办:北 京 中 医 药 大 学
ISSN 2095-6606 CN 10-1157/R

现代中医临床 ›› 2021, Vol. 28 ›› Issue (1): 18-21.doi: 10.3969/j.issn.2095-6606.2021.01.004

• 临床研究 • 上一篇    下一篇

基于数据挖掘的李曰庆教授治疗阳痿的用药经验*

王继升1, 代恒恒1, 鲍丙豪1, 龙中闻1, 邓省1, 冯隽龙1, 王彬2, 李海松2#   

  1. 1 北京中医药大学 北京 100029;
    2 北京中医药大学东直门医院
  • 收稿日期:2019-12-03 出版日期:2021-01-30 发布日期:2021-02-02
  • 通讯作者: #李海松,男,博士,主任医师,博士生导师,E-mail:1028bj@sina.com
  • 作者简介:王继升,男,在读博士生
  • 基金资助:
    *国家自然科学基金面上项目(No.81774320),北京中医药“薪火传承3+3工程”室站建设项目(No.2016-SZ-C-60)

Data mining-based Prof.Li Yueqing's experience with impotence therapy*

Wang Jisheng1, Dai Hengheng1, Bao Binghao1, Long Zhongwen1, Deng Sheng1, Feng Junlong1, Wang Bin2, Li Haisong2#   

  1. 1 Beijing University of Chinese Medicine, Beijing 100029;
    2 Dongzhimen Hospital, Beijing University of Chinese Medicine
  • Received:2019-12-03 Online:2021-01-30 Published:2021-02-02

摘要: 目的 探索分析李曰庆教授治疗阳痿的用药规律,为阳痿的治疗提供临床思路。方法 收集李教授治疗阳痿的处方,采用复杂系统熵聚类等数据挖掘方法,确定处方中药物的使用频次及药物之间的关联规则,总结李教授治疗阳痿的用药经验。结果 对筛选出的193首处方进行分析,处方中出现频次较高的中医证候依次是肾虚肝郁证、瘀血阻络证、肝气郁结证、命门火衰证、湿热下注证、惊恐伤肾证、心脾两虚证等。使用频次较高的前6味中药为牛膝、白芍、柴胡、巴戟天、五味子、淫羊藿。中药归经出现频次较多的前2位分别是肝经和肾经。基于关联规则挖掘出“牛膝,白芍” “白芍,柴胡”等15组高频药物组合,挖掘出茯苓→牛膝、枸杞子→牛膝、柴胡→牛膝等10种药物组合关联规则。基于无监督熵层次聚类分析挖掘出12首候选新处方。结论 李教授治疗阳痿经验丰富,治疗多以活血兴阳、疏肝补肾为主,并根据兼症加减用药。

关键词: 阳痿, 中医传承辅助系统, 用药规律, 名医经验, 李曰庆

Abstract: Objective To explore and analyze Professor Li Yueqing's medication rules for the treatment of impotence, and to provide clinical ideas for the management of this disease. Methods Prof. Li's prescriptions for the treatment of impotence were collected, and the complex system entropy clustering and other data mining methods were used to determine the frequency of the herbs in the prescriptions and the association rules so as to summarize Prof. Li's experience with the treatment of impotence. Results A total of 193 selected prescriptions were analyzed, and the high-frequency TCM patterns were successively kidney deficiency and liver stagnation pattern, pattern of blood stasis blocking collaterals, pattern of liver qi stagnation, pattern of fire failure of life gate, dampness-heat down-pouring pattern, fright and fear-induced kidney injury pattern, deficiency of the heart and spleen, etc. The top 6 traditional Chinese medicinals that are frequently used were Achyranthes bidentata, Radix paeoniae alba, Radix Bupleuri, Fructus schizandrae and Epimedium. The most attributive meridians were the Liver Meridian and Kidney Meridian. Based on association rules, 15 groups of high-frequency herb combinations were revealed, for instance, “Radix achyrandii and Radix paeoniae alba”, “Radix Paeoniae alba and Radix Bupleuri” and 10 herb combinations, including pachyrhizus, Fructus lycii, Radix achyrandii, and Radix Achyrandii were excavated. Based on unsupervised entropy hierarchical clustering analysis, 12 candidate new prescriptions were mined. Conclusions Prof. Li has rich experience in the treatment of impotence and his treatment is centered on promoting blood circulation and invigorating yang, soothing the liver and tonifying the kidney and modification is made to the prescription according to the patient's condition.

Key words: impotence, TCM inheritance assistance system, medication rules, famous physician's experience, Li Yueqing

中图分类号: 

  • R268