主 办:北 京 中 医 药 大 学
ISSN 2095-6606 CN 10-1157/R

现代中医临床 ›› 2021, Vol. 28 ›› Issue (2): 56-59.doi: 10.3969/j.issn.2095-6606.2021.02.012

• 方药研究 • 上一篇    下一篇

基于《中华医典》探讨从痰论治失眠的组方用药规律*

赵欣然, 刘文娜#, 程苗苗, 陈宝鑫, 张彩凡, 朱爽   

  1. 北京中医药大学东方医院脑病科 北京 100078
  • 收稿日期:2020-09-14 出版日期:2021-03-30 发布日期:2021-03-30
  • 通讯作者: #刘文娜,女,硕士,主任医师,硕士生导师,E-mail:dflwn@126.com
  • 作者简介:赵欣然,女,在读硕士生
  • 基金资助:
    *北京中医药大学基本科研业务费项目(青年教师项目)(No.2018-JYBZZ-JS154)

Chinese Medical Code-based medication rules for treatment of insomnia from phlegm*

Zhao Xinran, Liu Wenna#, Cheng Miaomiao, Chen Baoxin, Zhang Caifan, Zhu Shuang   

  1. Department of Encephalopathy, Oriental Hospital of Beijing University of traditional Chinese Medicine, Beijing 100078
  • Received:2020-09-14 Online:2021-03-30 Published:2021-03-30

摘要: 目的 探讨从痰论治失眠的组方用药规律,以指导临床用药。方法 检索《中华医典》数据库中的名方及医案部分中的全部古籍数据,收集整理治疗失眠症痰证的方药信息。对常用中药进行频次统计。基于关联规则分析治疗组方规律。基于聚类分析及因子分析提取主方。结果 在91首方剂中,共统计出133味中药,频次≥13的药物有20味,其中半夏频次最高,高达60次。治疗痰证失眠症常用中药以温性为主,共295次。治疗痰证失眠症常用中药以甘味为主,共446次。治疗痰证失眠症常用中药中,脾胃经用药频次最高,共496次。对91首方剂中频次≥13的中药进行因子分析,利用因子系数筛选出7个公因子,关联规则分析得到治疗痰证失眠症的药物组合14组。聚类分析生成聚类分析树状图,结合临床实际,提取4组聚类结果。治疗痰证失眠以理气、化痰、安神为基本治则,用药以甘温类药物为主,辛开苦降调畅气机,温胆汤和安神定志丸为两大主方,根据临床病情变化,随证加减可取得更好的临床疗效。结论 通过分析《中华医典》中从痰论治失眠的组方用药规律,为临床从痰论治失眠提供参考依据。

关键词: 失眠, 痰, 中华医典, 用药规律

Abstract: Objective To explore the medication rules for the treatment of insomnia from phlegm in order to guide the clinical use. Methods The data of famous prescriptions and medical records in the database of Chinese Medical Code were searched, and the information of prescriptions for the treatment of phlegm patterns of insomnia was collected. The frequency statistics of the commonly used traditional Chinese medicine was counted. The rule of treatment group was analyzed based on association rules. The majorprescriptions were extracted based on cluster analysis and factor analysis. Results Among the 91 prescriptions, a total of 133 traditional Chinese medicines were counted, and 20 medicines with frequency≥13 were found, of which the frequency of Banxia (RhizomaPinelliae) was the highest, as high as 60 times. Medicinals used for the treatment of phlegm syndrome insomnia were mainly warm in nature,295 times. Sweet taste is the main traditional Chinese medicine in the treatment of phlegm syndrome insomnia. There were 84 times of sour taste and only 42 times of salty medicine. Among the commonly used traditional Chinese medicines for treating insomnia of phlegm syndrome, the frequency of the Spleen and Stomach Meridian was the highest (496 times). Factor analysis was carried out on the traditional Chinese medicine with the frequency ≥20 in 91 prescriptions. Seven common factors were screened by factor coefficient, and 14 groups of drug combinations for treating insomnia with phlegm syndrome were obtained by association rule analysis. The tree diagram of cluster analysis was generated by cluster analysis, and four groups of clustering results were extracted according to clinical practice. The treatment of phlegm syndrome insomnia was based on regulating qi, resolving phlegm and calming the mind as the basic treatment principles, and the drugs are mainly sweet and warm drugs, pungent and bitter to regulate qi movements, Wendan Decoction and Anshen Dingzhi Pills are the two main prescriptions, according to the changes of clinical condition, a better clinical effect can be obtained by adding or removing medicinals based on the syndrome. Conclusions Through the analysis of the prescription and medication rules of treating insomnia from phlegm in Chinese Medical Code, it can provide references for clinical treatment of insomnia from phlegm.

Key words: Insomnia, phlegm, Chinese Medical Code, medication rules

中图分类号: 

  • R256.23