主 办:北 京 中 医 药 大 学
ISSN 2095-6606 CN 10-1157/R

现代中医临床 ›› 2021, Vol. 28 ›› Issue (3): 59-63.doi: 10.3969/j.issn.2095-6606.2021.03.013

• 文献研究 • 上一篇    下一篇

基于数据挖掘分析中医治疗非小细胞肺癌EGFR-TKIs腹泻用药规律*

范振佳1, 黄金昶1, 周慧锋2, 郝迎旭3#   

  1. 1 北京中医药大学第三附属医院 北京 100029;
    2 北京市朝阳区平房社区卫生服务中心;
    3 中日友好医院中西医结合肿瘤内科
  • 收稿日期:2020-11-20 出版日期:2021-05-30 发布日期:2021-06-08
  • 通讯作者: #郝迎旭,女,主任医师,硕士生导师, E-mail:haoyingxu@126.com
  • 作者简介:范振佳,女,在读博士生
  • 基金资助:
    *国家自然科学基金面上项目(No.82074545),北京中医药薪火传承“3+3”工程张代钊名医传承工作站建设项目(No.2007-SZ-C-12)

Medication rules of TCM treatment of EGFR-TKIS related diarrhea in non-small cell lung cancer based on data mining*

Fan Zhenjia1, Huang Jinchang1, Zhou Huifeng2, Hao Yingxu3#   

  1. 1 Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing 100029;
    2 Pingfang Community Health Service Center, Chaoyang District;
    3 China-Japan Friendship Hospital
  • Received:2020-11-20 Online:2021-05-30 Published:2021-06-08

摘要: 目的 挖掘分析中医治疗非小细胞肺癌EGFR-TKIs相关腹泻的用药规律。方法 检索中国知网数据库、万方数据知识服务平台及维普中文期刊服务平台,收集、筛选相关文献,应用古今医案云平台V2.2.3版,对中医证候、中药频次、四气、五味、归经等进行分类统计,分析配伍规律,并进行聚类分析。结果 中医证候频次最高的是气阴两虚证;中药使用频次最高的是黄芪,其次为白术与茯苓;用药以性平、味甘、归脾胃肺经的中药为主;得到六对频次及可靠度均较高的药物组合,层次聚类分析得到两大类共4组药物,均以益气养阴,健脾化痰为主要功效。结论 非小细胞肺癌EGFR-TKIs相关腹泻以气阴两虚、脾弱痰蕴为病机特点,常见中医证候为气阴两虚证,治疗以益气养阴,健脾化痰为主,用药以性平、味甘、脾胃肺经药物为主。

关键词: 靶向药物, 非小细胞肺癌, EGFR, 中医治疗, 数据挖掘

Abstract: Objective To explore and analyze the medication law of traditional Chinese medicine in the treatment of EGFR-TKIs associated diarrhea (epidermal growth factor receptor, EGFR; tyrosine kinase inhibitors,TKIs) in non-small cell lung cancer. Methods Related literature was retrieved from CNKI, Wan Fang(WF) and VIP databases. TCM syndromes, TCM frequency, four qi, five flavors, tropism, etc. were counted, compatibility rules were analyzed and cluster analysis with ancient and modern medical case cloud platform V2.2.3. was conducted. Results The highest frequency of TCM syndromes was deficiency of qi and Yin. Astragalus membranaceus was most frequently used, followed by atractylodes and Poria cocos. The main medicinals were medicinals that had a neutral nature, a sweet taste and those which were attributive to the spleen, stomach and lung meridians. Six drug combinations with high frequency and reliability were obtained, and four groups of medicinals in two categories were obtained, all of which had the main effects of enhancing qi and nourishing Yin, strengthening spleen and resolving phlegm. Conclusions Diarrhea associated with EGFR-TKIS of non-small cell lung cancer is characterized by the deficiency of qi and Yin and the accumulation of phlegm in the spleen, and the common TCM syndromes are the deficiency of qi and Yin. The treatment focuses on promoting qi and nourishing Yin, strengthening the spleen and resolving phlegm, and the commonly used medicinals are medicinals with a neutral nature, a sweet taste and attributive to the spleen, stomach and lung meridians.

Key words: targeted drugs, non-small cell lung cancer, epidermal growth factor receptor, treatment in traditional Chinese medicine

中图分类号: 

  • R273