Objective To observe the clinical efficacy of Yijing Decoction plus Levocarnitine and Coenzyme Q₁₀ (CoQ₁₀) for asthenospermia of the spleen-kidney deficiency pattern.Methods 68 patients with asthenospermia of the spleen-kidney deficiency pattern were randomly assigned to the treatment group and control group,with 34 cases in each group.After shedding cases were removed,there were 33 left in each group.The patients in the control group were treated with Levocarnitine Oral Solution and CoQ₁₀ Pill while the patients in the treatment group additionally received Yijing Decoction in addition to the Western medical treatment.The progressive motility (PR),total motility (progressive+non-progressive motility,PR+NP),clinical efficacy,TCM syndrome score and therapeutic effect of TCM syndromes were observed.Results After treatment,PR and PR+NP in both groups were significantly increased,as compared with that before treatment and the differences were statistically significant (P<0.05).PR and PR+NP were more markedly elevated in the treatment group than in the control group,and the differences in scores before and after treatment in both groups were statistically significant (P<0.05),better in the treatment group than in the control group.Among the 33 patients in the treatment group,9 were cured,10 were significantly effective,8 were effective and 6 were ineffective,the total number of effective cases was 27 and the total effective rate was 81.81%.In the control group,there were 5 cured cases,3 obvious cases,9 effective cases and 16 ineffective cases,the total number of effective cases was 17,and the total effective rate was 51.52%.After rank sum test,Z=-2.754,P=0.006,P<0.05,the clinical efficacy of the treatment group was better than that of the control group.After treatment,TCM syndrome scores of the two groups were lower than those before treatment,and the differences were statistically significant (P<0.05),significantly lower in the treatment group than in the control group (P<0.05).Among the 33 patients in the treatment group,9 were cured,3 were significantly effective,16 were effective and 5 were ineffective.With a total of 28 effective cases,the total effective rate was 84.85%.In the control group,there was no cured case,1 obvious case,14 effective cases and 18 ineffective cases.With a total of 15 effective cases,the total effective rate was 45.46%. Rank sum test showed Z=-4.077,P=0.000 (P<0.01),indicating that the therapeutic effect of TCM syndromes was better in the treatment group than in the control group.Conclusions Yijing Decoction plus Levocarnitine and CoQ₁₀ has good effects on asthenospermia of the spleen-kidney deficiency pattern.

Objective To evaluate the clinical efficacy of Changweishu Capsule for diarrhea of the spleen-stomach dampness-heat pattern in patients with cancer.Methods One hundred and four patients with tumor-related diarrhea of the spleen-stomach dampness-heat pattern were randomly assigned to the test group(n=63)and the control group(n=30).The test group was treated with Changweishu Capsule (4 capsules per time,3 times a day).The control group was treated with Xianglian tablets (5 tablets per time,3 times a day).Both groups were administered continuously for 2 weeks.The TCM syndrome scores,TCM syndrome efficacy and single symptom efficacy were compared before and after treatment,and safety indicators were observed.Adverse reactions were recorded.Results Among the 63 cases in the test group,3 cases were cured,15 cases were markedly effective,39 cases were effective,6 cases were ineffective,the total number of effective cases were 57,and the total effective rate was 90.5%.Among the 30 cases in the control group,none was cured,5 cases were markedly effective,18 cases were effective,7 cases were ineffective,the total number of effective cases was 23,and the total effective rate was 76.7%.Rank sum test showed that Z=-1.913,P=0.056(P>0.05),indicating that the symptoms curative effects of the two groups were not significantly different.Both drugs reduced the total score of TCM syndromes of tumor-related diarrhea(P<0.05).The test group decreased significantly as compared with the control group (P<0.05).After treatment,the scores of diarrhea,abdominal fullness,food intake,hiccup and nausea,dry mouth and bitter taste in the two groups all decreased.The scores of diarrhea and abdominal fullness in the test group were greatly lowered,as compared with the control group (P<0.05).During the observation,no adverse reactions were found during the observation process.Conclusions Both Changweishu Capsule and Xianglian Tablets can improve the clinical symptoms in tumor-related diarrhea and abdominal fullness.Changweishu Capsule has better efficacy in improving the two single symptoms of diarrhea.

Objective To analyze the characteristics and distribution of TCM patterns of multiple sclerosis to provide reference for standardization of TCM patterns of multiple sclerosis (MS) and for clinical research.Methods The medical records of 78 patients who visited the Department of Encephalopathy in Dongzhimen Hospital,Beijing University of Chinese Medicine from January 2011 to August 2019 were collected retrospectively,totaling 308 case reports.Principal component analysis and cluster analysis were performed on the four diagnostic information of TCM incorporated into the medical records.Results A total of 115 diagnostic information of four diagnoses were collected from 78 MS patients with 308 case reports,10 of which had frequency≥25%,including fine pulse,thin white coating,dark red tongue,limb numbness,wiry pulse,sunken pulse,fatigue,greasy coating,limb weakness and yellow coating.30 diagnostic data with frequency≥8% were selected for principal component analysis,and a total of 11 common factors were obtained.The maximum variance method was used to rotate the component matrix to obtain the load factor,and factor coefficient was used to screen out the information corresponding to 11 diagnostic information with principal components.Based on the clustering analysis,the clustering results showed that there were 5 types of TCM patterns,which were successively from high to low in proportion:spleen and kidney yang deficiency accounting for 32.46%,qi and blood deficiency accounting for 24.03%,dampness-heat immersion accounting for 21.42%,liver and kidney deficiency accounting for 12.34%,and dampness and turbid retention accounting for 9.74%.The proportion of principal components involved in kidney localization was 44.81%,and the proportion involved in pathogenic dampness was 31.17%,among which the proportion of dampness-heat was relatively high.Conclusions By using principal component analysis and cluster analysis,the characteristics and distribution of TCM patterns of MS patients are studied,which is of certain reference value for the standardization and clinical research of TCM patterns of multiple sclerosis.

Objective To investigate the clinical effect of warming acupuncture as an adjuvant therapy for bladder spasms after transurethral resection of the prostalt.Methods Eighty patients undergoing transurethral resection of prostate were randomly assigned to the treatment group and control group,with 40 cases in each group.Patients in both groups had traditional stepwise resection.The control group was treated with Toterodine tablets after operation.The observation group received additional warming acupuncture.The number of bladder spasms,duration of spasms,pain degree of bladder spasms,time of flushing fluid clearance,bladder condition perception scale score (patient perception of bladder condition measure,PPBC) and bladder hyperactivity score (overactive bladder symptom score,OABSS) were observed.Results The number of bladder spasms was significantly lower,the duration of spasms and the time of flushing fluid were significantly shorter and the VAS score was significantly lower in the treatment group than in the control group(P<0.05).The time of extubation was shorter in the treatment group than in the control group,the urine volume was increased,and the incidence of urinary retention and incontinence after extubation was lower in the treatment group than in the control group (P<0.05).The PPBC and OABSS after treatment were significantly lower than those before treatment in both groups(P<0.05),and the before-after treatment differences in PPBC and OABSS were significantly lower in the treatment group than in the control group (P<0.05).Conclusions Warming acupuncture as an adjuvant therapy in the treatment of bladder spasms with toterodine after transurethral resection of the prostalt has a good clinical effect.

Objective To explore the clinical efficacy of the treatment of acupuncture &decoctions for depression in German patients.Methods 120 hospitalized patients with depression in Germany received individulized TCM decoctions plus acupuncture treatment based on syndrome differentiation with acupoints selected mainly from the Governor Vessel,the Liver Meridian of Foot-Jueyin,and the Heart Meridianof Hand-Shaoyin. The scores of self-rating depression scale (SDS) and self-rating anxiety scale (SAS),dosage of antidepressants and changes of clinical symptoms were observed before and after treatment.Results Among the 120 cases treated with traditional Chinese medicine and acupuncture,19 cases were markedly effective,66 cases were effective,32 cases were ineffective and3 cases were aggravated,with a total effective rate of 70.8%.At 6 months after discharge,48 cases were followed up,accounting for 40.0% of the cases.Among them,36 cases (75.0%) were continuously effective.After treatment,SDS scores of 120 cases decreased significantly,as compared with those before treatment (P<0.05).The SAS score of 90 patients with anxiety was significantly lower after treatment than before treatment (P<0.05).Among the 120 cases,70 cases (58.3%) reduced the amount of antidepressants,and 20 cases (16.7%) stopped using antidepressants.Fatigue improved in 86 cases,accounting for 71.7%;anxiety symptoms improved in 78 cases,accounting for 65.0%;sleep disorders improved in 75 cases,accounting for 62.5%.Conclusions The combination of acupuncture and decoctions is effective for depression among German patients,which is worth further study and promotion.

Objective To analyze the academic character and medication rules of Professor Yanqin Zou in treating immunoglobulin A (IgA) nephrology.Methods Using Chinese medicine heritage platform software,we collected and analyzed 76 IgA nephrology cases treated by Prof.Zou.Frequency statistics were used for single-agent drugs,and association rule was used to analyze pharmaceutic rules.Core drug combinations were extracted based on complex system entropy clustering and candidate new prescriptions were obtained based on unsupervised entropy hierarchical clustering.Results Among the 76 prescriptions,a total of 123 drugs were used,13 of which were used more than 40 times.Huangqi (Radix Astragali)was the most frequently used medicinal,with its frequency up to 70 times.The frequently-used medicinals were mainly cold in nature,614 times in total.Among the frequently-used medicinals,sweet flavor is the most commonly used herb flavour,with a total of 1 054 times.Medicinals attributive to the Liver Meridian were the most frequent,up to 853 times.According to association rule data mining method,8 groups with higher correlation coefficient were “Gancao (Radix et Rhizoma Glycyrrhizae) plus Huangqi(Radix Astragali)”,“Fulin(Poria)→Huangqi(Radix Astragali)”,“Yiyiren(Semen Coicis)→Huangqi(Radix Astragali)”,“Jiangchan(Bombyx Batryticatus)→Huangqi(Radix Astragali)”,“Huangqi(Radix Astragali)→Jiangchan(Bombyx Batryticatus)”,“Shiwei→Huangqi(Radix Astragali)”,“Niubangzi(Fructus Arctii)→Huangqi(Radix Astragali)” and “Huangshukuihua→Huangqi(Radix Astragali)”.Based on complex system entropy clustering,a group of 13 core drug combinations were obtained.Based on unsupervised entropy hierarchical clustering,3 new prescriptions were obtained.Professor Zou’s academic experience in treating IgA nephropathy mainly included three parts.Firstly,the location of the disease was identified,which included the lungs,spleen and kidney.Secondly,the nature of disease was analyzed,which aimed to strengthen the body resistance to eliminate pathogenic factors.Finally the course of the disease was analyzed.Activating blood circulation was used for diseases with long durations.Conclusions Through combining the data mining of medical records together with the introduction of academic characteristics,we summarized the experience of Prof.Zou in the treatment of IgA nephropathy.

The ischemic ulcer of diabetic lower limb with ineffective vascular reconstruction refers to the severe limb ischemic ulcer secondary to diabetes mellitus combined with lower extremity arterial disease through surgical bypass or endovascular treatment.Wound pain and difficulty to heal are its main symptoms,which belong to gangrene in traditional Chinese medicine.Based on the theory of meridians and collaterals,Prof.Lyu Peiwen pointed out that the basic pathogenesis of the disease is deficiency of the spleen,kidneys,heart qi,blood and yin-yang deficiency.The excess is characterized by toxin and stasis,which involve the dampness,phlegm and heat.Prof.Lyu Peiwen regulated the constitution and the microenvironment for the lesions through reviving yang to generate muscles,activating blood to generate muscles and transforming the rotted to generate muscles.Simultaneously,two therapeutic methods of replenishing and relieving collaterals were applied to reconstruct blood circulation,which was key to the treatment.

Ye Tianshi,a famous doctor in the Qing Dynasty,had not only profound attainments in the clinical diagnosis and treatment of warm diseases,but also distinctive understanding and insights into constitution.Case Records as a Guide to Clinical Practice advocated that constitution differentiation should be prior to disease treatment and disease differentiation should observe the yinyang principle.Given that various factors may affect the constitution,the evaluation and treatment of the constitution is related to the formation of prescriptions and medication.In addition,dietary indication and contraindiations should also take consitution into considertaion.The ideas concerning consititution are unique and are still enlightening to the current clinical practice.

The traditional Chinese medicine classic Huangdi Neijing says:“When there are cardiopulmonary lesions,the nose is inhibited”,of which most annotations cared about the correlation between the nose and lungs,rather than between the nose and heart.However,from literature research and clinical practice,it is necessary to elucidate the close physiological and pathological correlation between the heart and nose.Physiologically,the correlation between the heart and nose are actually extentions of the correlation between the heart and lung.If heart qi is sufficient,the nose is alert.Pathologically,yang deficiency gives rise to phlegm retention and qi stagnation in the chest;if heart vessels are blocked,then the nosal collaterals would be blocked.Clinically,whether the nose is inhibited or not helps to form a first impression about the cardiac function.What’s more,when dealing with nasal congestion,one should take the heart into considertation.It’s a good example to show Huangdi Neijing’s guidance on TCM clinical practice.

The method of lifting the pot and uncovering the lid reveals the key role of the lung and Xuanfu in maintaining the qi movement of the human body,including the theoretical connotation of"tongfu ”and" yinzhi therapy"."Doors,holes,dens,kong,passes,gaps,fu,tunnels,roads,jiao" and other tissues are all "integrated into one organ where one qi circulates".The skillful application of "tongfu" and "yinzhi therapy" is helpful to activate the qi movement and achieve the purpose of preventing and curing miscellaneous diseases.

Interviewing is a kind of qualitative method to collect data by conversations following some regulations,with an increasing number of traditional Chinese medicine (TCM) studies applying this method year by year.The main topics of TCM interviewing studies currently include clinical practice experience and methods,perspectives,experience and willingness of the patients to receive TCM treatment,application and education of TCM,and the development of TCM scales.Considering the characteristics of TCM wholism and syndrome differentiation and treatment,it is very adaptive to use interviewing in TCM research so as to add and explore more information.It would be possible to make a comprehensive exploration in the following aspects by quantitative research and interviewing,such as the data mining of the experience from famous old experts,construction of disease syndrome evolution and outcome indexes,construction of diagnosis and treatment model based on syndrome differentiation,elements research on TCM efficacy evaluation,solving the barriers in TCM scientific research,quality assessment in the different stages of TCM scientific research,and TCM educational management.

Vertigo is a disease characterized by dizzy vision,including diseases with chief complaints of dizziness or vertigo.As for the differential treatment of vertigo in traditional Chinese medicine,the following 4 principles should be noted:with reference to the diagnosis and treatment of vertigo in modern medicine,the advantages of both Chinese and Western medicine should be brought into full play;Risk factors should be removed to regulate zang-fu organs;treatment differs for different diseases;functional training should be performed and a balanced diet is recommended.The diagnostic process covers the following four-step procedures,namely,identifying the symptoms(vertigo),identifying disease location,identifying disease nature and identifying TCM patterns.Treatment principles are different for the attack stage and remission stage.The major treatment methods are Chinese medicine,appropriate techniques of traditional Chinese medicine,modern medical techniques,and nursing regulation,depending on the characteristics of the disease.

Tic disorders (TD) is a neuropsychiatric disease with obvious genetic predisposition.Its incidence has been on the rise in recent years.It is often accompanied by comorbidities such as behavioral disorders and emotional disorders.It is easily affected by various factors.It leads to recurrent symptoms,which seriously affects the children's learning,life,and social adaptability,and clinical treatment is difficult.Psychoeducation and behavioral treatment is an important means to regulate TD stress sensitivity.Yi Jin Jing is a Chinese medical guiding method through stretching tendons and bones and rotating the spine.It can improve TD stress sensitivity,fight against motor and vocal tic symptoms,adjust the body and mind,correct comorbidities,and practice together with the family,which is safe and feasible.Yi Jin Jing has a certain preventive effect on tic disorders.

Immunotherapy for malignant tumors is a hot issue in the field of tumor treatment,but its adverse reactions such as immune associated colitis not only affect tumor treatment,but also reduce the life quality of patients.Wumei Pill is of certain clinical effects on immunotherapy related enteritis.The pathogenesis of immunotherapy related colitis is characterized by the deficiency and excess complex,as well as intermingled cold and heat while Wumei Pill can be applied to the disease of intermingled cold and heat.Immunotherapy related colitis belongs to Jueyin diseases while Wumei Pill is the first choice for Jueyin diseases recorded in Treatise on Cold Damage.Visceral cold is the main cause of immunotherapy related colitis,and Wumei Pill is the basic and important prescription indicated for the diarrhea of cold and heat.The whole prescription of Wumei Pill can achieve the therapeutic purpose of tonifying with no pathogenic factors left and clearing away heat without injuring the healthy Qi.Wumei Pill can resist the wind by the sour agents,strengthen Yang with heat herbs,and enrich Yin with herbs of bitter and sour.Moreover,it integrates the methods of warming and clearing,attacking and reinforcing,with remarkable therapeutic effects for immunotherapy related enteritis.Wumei Pill uses sour medicine in great quantity,together with a small amount of cold and heat drugs,to regulate Yin and Yang.Tonic and cathartic are used simultaneously,with care to healthy Qi.

Medicine is a science with strong practicality and application.The cultivation of clinical practical skills has an important role in the teaching of medical knowledge and ability.The TCM Gynecology Teaching and Research Section of the Third Affiliated Hospital of Beijing University of Chinese Medicine established the method of problem-based learning (PBL) plus simulated clinical practice teaching,and applied it to clinical teaching of TCM gynecology.This teaching method explores the practice and model of PBL plus simulated practical teaching from the following perspectives:teaching issues,the writing of simulated practice scripts,and the determination of gynecological practice projects.The evaluation methods for PBL plus simulated clinical practice teaching include PBL plus simulated outpatient diagnosis and treatment scoring,PBL teaching plus ward scenario simulation teaching scoring,gynecological examination scoring,hand brushing and disinfection assessment scoring.The implementation effect of this teaching model will be evaluated in combination with practical teaching.We have gained good results through PBL plus simulated clinical practice teaching method applied to the clinical teaching of TCM gynecology.

Objective To analyze the columns of Modern Chinese Clinical Medicine,and determine the key and characteristic columns,especially the academic vitality of the key columns and their contribution to the influence of the journal.Methods With the articles published in each column of Modern Chinese Clinical Medicine from 2014 to 2018 as the research object,and CNKI as the data source,bibliometrics was used to conduct statistical analysis of the composition ratio,average download frequency,and citation frequency of each column.Results The top 5 column contribution values from 2014 to 2018 were:“special research”,“review”,“clinical research”,“famous doctor inheritance” and “ideas and methods”.The top 5 citations per article were:“expert consensus” (14.00 times),“special research” (9.68 times),“review” (8.84 times),“expert experience” (8.67 times) and “clinical observation”(7.46 times).The top 5 articles with average download times were:“expert consensus” (460.00 times),“evidence-based medicine” (410.27 times),“reviews” (406.42 times),“narrative medicine”(372.56 times) and “master of traditional Chinese medicine” (333.50 times).The 3 columns with the lowest citations per article were:“case report” (0.7 times),“Chinese medicine clinical education”(1.00 times) and “master forum” (1.00 times).Conclusions Mand The columns of this journal need to be further streamlined,with the goal of creating a “premium journal”;the key columns are “special research”,“review”,“clinical research”,“inheritance of famous doctors” and “ideas and methods”.“Narrative medicine”,“expert experience”,“master of traditional Chinese medicine”,and “famous forum” are famous columns.In the future work,we should adhere to the column orientation and strive to improve the quality of the columns and the quality of publications.