Study on the "supplementing the kidney, fortifying the spleen and invigorating blood" principle in the treatment of osteoporotic vertebral fractures based on the theory of disharmony between bones and muscles

YUAN Lin; LI Yafeng; ZHAO Xueqian; YANG Haotian; MA Hui; TAN Jiansheng; QIN Weiming; JIA Yusong

doi:10.3969/j.issn.2095-6606.2023.01.017

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Study on the "supplementing the kidney, fortifying the spleen and invigorating blood" principle in the treatment of osteoporotic vertebral fractures based on the theory of disharmony between bones and muscles

更新时间：2023-02-02

- Study on the "supplementing the kidney, fortifying the spleen and invigorating blood" principle in the treatment of osteoporotic vertebral fractures based on the theory of disharmony between bones and muscles
- Modern Chinese Clinical Medicine Vol. 30, Issue 1, Pages: 72-75(2023)
- 作者机构：
  
  1.北京中医药大学东直门医院　北京　100700
  2.清华大学附属中西医结合医院
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2023.01.017
  CLC： R274.1
- Received：24 March 2022，
  
  Published：30 January 2023
- 稿件说明：
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YUAN Lin, LI Yafeng, ZHAO Xueqian, et al. Study on the "supplementing the kidney, fortifying the spleen and invigorating blood" principle in the treatment of osteoporotic vertebral fractures based on the theory of disharmony between bones and muscles[J]. Modern Chinese Clinical Medicine, 2023, 30(1): 72-75.
DOI：

YUAN Lin, LI Yafeng, ZHAO Xueqian, et al. Study on the "supplementing the kidney, fortifying the spleen and invigorating blood" principle in the treatment of osteoporotic vertebral fractures based on the theory of disharmony between bones and muscles[J]. Modern Chinese Clinical Medicine, 2023, 30(1): 72-75. DOI： 10.3969/j.issn.2095-6606.2023.01.017.

摘要

骨质疏松性椎体骨折(OVF)是最常见的骨质疏松性骨折类型，肌少症与骨质疏松症是OVF的高危因素。OVF、肌少症与骨质疏松症，可归属于中医学“痿证”“肉痿”“骨蚀”等范畴。骨与肉实为肾脏与脾脏之间关系的演变，脾肾功能正常是骨肉相亲的生理基础。骨骼、肌肉均源于近轴中胚层体细胞，在结构、功能以及生物力学与分子生物学方面均紧密关联。OVF的发生，跌扑闪挫是诱因，肾虚是根本，脾虚是关键，血瘀是主要病理产物，脾肾亏虚兼血瘀是OVF的主要病因病机。OVF的病理改变微观上是线粒体功能障碍导致肌肉蛋白合成不足，宏观上是骨骼肌质量与收缩力下降加重肌少症与骨质疏松症进展。补肾健脾活血治疗OVF符合未病先防、既病防变、瘥后防复的治疗原则。

Abstract

Osteoporotic vertebral fracture (OVF) is the most common type of osteoporotic fracture

for which sarcopenia and osteoporosis are among the high-risk factors. OVF

sarcopenia and osteoporosis fall into the TCM categories of "flaccidity syndrome (

wěi zhèng

"fleshy flaccidity (

ròu wěi

and "bone erosion (

gǔ shí

respectively. TCM believes that the relationship between bones and muscles is in fact the continuation of that between the kidney and the spleen

which further suggests that the normal functioning of the two viscera is the physiological basis of the bone-muscle harmony. Bones and muscles

both stemming from paraxial mesodermal somatic cells

are closely related with each other in structure

function

biomechanics and molecular biology. In the occurrence of OVF

injuries due to falling

tumbling

spraining

or contusion are the inducement

while kidney deficiency is the root

spleen deficiency is the key

and blood stasis is the main pathological product

indicating that spleen-kidney deficiency and blood stasis are the main causes and pathogenesis of OVF. Microscopically speaking

mitochondrial dysfunction leads to insufficient muscle protein synthesis

which manifests in the decline of skeletal muscle mass and contractility

aggravating sarcopenia and osteoporosis. The treatment of OVF by the method of supplementing the kidney

fortifying the spleen and invigorating blood is in line with the principle of prevention before disease onset

controlling development of existing diseases and keeping the disease from recurring after recovery.

关键词

Keywords

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