Logistic regression analysis of influencing factors of syndrome differentiation in 417 patients with primary glomerulonephritis

JIA Meng; HAN Shisheng; WANG Yi

doi:10.3969/j.issn.2095-6606.2023.04.009

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Logistic regression analysis of influencing factors of syndrome differentiation in 417 patients with primary glomerulonephritis

Clinical Research | 更新时间：2023-08-07

- Logistic regression analysis of influencing factors of syndrome differentiation in 417 patients with primary glomerulonephritis
- Modern Chinese Clinical Medicine Vol. 30, Issue 4, Pages: 42-48(2023)
- 作者机构：
  
  上海中医药大学附属岳阳中西医结合医院肾内科　上海　200437
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2023.04.009
  CLC： R259
- Received：26 September 2022，
  
  Published：30 July 2023
- 稿件说明：
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JIA Meng, HAN Shisheng, WANG Yi. Logistic regression analysis of influencing factors of syndrome differentiation in 417 patients with primary glomerulonephritis[J]. Modern Chinese Clinical Medicine, 2023, 30(4): 42-48.
DOI：

JIA Meng, HAN Shisheng, WANG Yi. Logistic regression analysis of influencing factors of syndrome differentiation in 417 patients with primary glomerulonephritis[J]. Modern Chinese Clinical Medicine, 2023, 30(4): 42-48. DOI： 10.3969/j.issn.2095-6606.2023.04.009.

摘要

目的

基于Logistic回归分析探讨原发性肾小球肾炎患者标实证辨证影响因素。

方法

对417例上海中医药大学附属岳阳中西医结合医院肾内科、上海中医药大学附属龙华医院肾内科、上海中医药大学附属第七人民医院肾内科住院，并行活检病理检查的原发性肾小球疾病患者进行回顾性研究，采用无序多分类Logistic回归相关性分析，分析原发性肾小球疾病标实证与肾脏病理组织学病变和生化指标等35项自变量之间的相关性。

结果

无标实证患者184例，标实证(含标实合并证)233例，水湿证患者156例，湿热证患者65例，血瘀证患者9例。以无标实证为对照，水湿证的辨证影响因素为：24 h尿蛋白定量(

0.05)，呈正相关；血红蛋白(

0.05)，呈负相关；血清白蛋白(

0.05)，呈负相关。湿热证的辨证影响因素为血清白蛋白(

0.05)，呈负相关。血瘀证的辨证影响因素为肾小球细胞增殖程度积分(

0.05)，呈正相关。

结论

原发性肾小球肾炎患者水湿证辨证影响因素为24 h尿蛋白定量、血红蛋白、血清白蛋白，湿热证辨证影响因素为血清白蛋白，血瘀证辨证影响因素为肾小球细胞增殖程度积分。

Abstract

Objective

To investigate the influencing factors of standard empirical syndrome differentiation in patients with primary glomerulonephritis using logistic regression analysis.

Methods

A retrospective study was conducted on 417 patients with primary glomerular disease who were admitted to the Department of Nephrology at Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine

the Department of Nephrology at Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine

and the Department of Nephrology at the Seventh People’s Hospital affiliated to Shanghai University of Traditional Chinese Medicine for concurrent biopsy and pathological examination. Random multiclass logistic regression correlation analysis was used to analyze the correlation between 35 independent variables such as primary glomerular disease markers and renal histopathological changes and biochemical indicators.

Results

There were 184 patients with non-standard empirical evidence

233 with standard empirical evidence (including combined standard empirical evidence)

156 with water dampness syndrome

65 with dampness heat syndrome

and 9 with blood stasis syndrome. Those with non-standard empirical evidence were used as a control

and the influencing factors of water dampness syndrome differentiation are: 24-hour urine protein quantification (

0.05)

showing a positive correlation

hemoglobin (

0.05)

negatively correlated

serum albumin (

0.05)

showing a negative correlation. The influencing factor of dampness heat syndrome differentiation is serum albumin (

0.05)

which is negatively correlated. The influencing factor of blood stasis syndrome differentiation is the integral of glomerular cell proliferation degree (

0.05)

which is positively correlated.

Conclusion

The influencing factors for the differentiation of water dampness syndrome in patients with primary glomerulonephritis are 24-hour urine protein quantification

hemoglobin

and serum albumin. The influencing factor for the differentiation of dampness heat syndrome is serum albumin

while the influencing factor for the differentiation of blood stasis syndrome is the degree of glomerular cell proliferation integral.

关键词

Keywords

references

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