Exploring the relevance of the intestinal-ovarian axis to polycystic ovary syndrome based on the principle that the spleen governs transportation and transformation

ZENG Genping; MIAO Yuxi; LI Peiyin; LU Xijing; LIU Sishi; ZENG Lei

doi:10.3969/j.issn.2095-6606.2023.05.018

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Exploring the relevance of the intestinal-ovarian axis to polycystic ovary syndrome based on the principle that the spleen governs transportation and transformation

Theoretical Exploration | 更新时间：2023-10-12

- Exploring the relevance of the intestinal-ovarian axis to polycystic ovary syndrome based on the principle that the spleen governs transportation and transformation
- Modern Chinese Clinical Medicine Vol. 30, Issue 5, Pages: 89-93(2023)
- 作者机构：
  
  1.广州中医药大学　广州　510405
  2.广州中医药大学第一附属医院
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2023.05.018
  CLC： R271.9
- Received：18 January 2023，
  
  Published：30 September 2023
- 稿件说明：
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ZENG Genping, MIAO Yuxi, LI Peiyin, et al. Exploring the relevance of the intestinal-ovarian axis to polycystic ovary syndrome based on the principle that the spleen governs transportation and transformation[J]. Modern Chinese Clinical Medicine, 2023, 30(5): 89-93.
DOI：

ZENG Genping, MIAO Yuxi, LI Peiyin, et al. Exploring the relevance of the intestinal-ovarian axis to polycystic ovary syndrome based on the principle that the spleen governs transportation and transformation[J]. Modern Chinese Clinical Medicine, 2023, 30(5): 89-93. DOI： 10.3969/j.issn.2095-6606.2023.05.018.

摘要

多囊卵巢综合征(polycystic ovary syndrome，PCOS)是育龄期女性常见神经内分泌代谢性疾病。越来越多研究表明，肠道菌群与PCOS之间存在密切联系。菌群失调参与PCOS发生发展，影响机体内分泌、炎症及能量代谢，调节肠道菌群可有效改善PCOS症状。祖国医学的“脾胃”包含肠道菌群，“脾主运化”的科学内涵包括肠道菌群及其互相牵制影响的内在联系。中医学认为PCOS关键病机当属脾虚痰湿内蕴，法当健脾胃、益生化、行气血、化痰湿，这与调节肠道菌群机理不谋而合。故本文立足于“脾主运化”，剖析肠道—卵巢轴与PCOS的相关性，旨在揭示肠道—卵巢轴及“脾主运化”在PCOS诊治中的重要性。

Abstract

Polycystic ovary syndrome (PCOS) is a common neuroendocrine metabolic disorder in women of childbearing age. A growing body of research has shown a strong link between intestinal flora and PCOS. Dysbiosis is involved in the development of PCOS and affects the endocrine

inflammatory and energy metabolism of the body

and regulating the intestinal flora can effectively improve the symptoms of PCOS. The scientific connotation of "the spleen and stomach" in TCM theories includes the intestinal flora

and the concept that "the spleen is responsible for transport and transformation" essentially involves the intestinal flora and its interlocking influence. TCM believes that the key pathogenesis of PCOS is spleen deficiency

and the result ant accumulation of phlegm and dampness

and the focus of treatment should be placed on strengthening the spleen and stomach

aid generation and transformation

promote the movement qi and blood

and resolve phlegm and dampness

which coincides with the mechanism of regulating the intestinal flora. Therefore

based on the principle of "the spleen governs transportation and transformation"

this article analyses the relevance of the intestinal-ovarian axis to PCOS

aiming to reveal the importance of the intestinal-ovarian axis and the theory of "generation and transformation" in the diagnosis and management of PCOS.

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references

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