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Modern Chinese Clinical Medicine
影响因子：1.174 ISSN：2095-6606CN：10-1157/R 出版周期：Bimonthly 邮箱：xdzylc@bucm.edu.cn最新刊期：2026年 第3期
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Special Topic Research
摘要：The theory of Wuyun Liuqi (Five Circuits and Six Qi) is an ancient doctrine that investigates the periodic patterns of celestial qi transformation and their influence on terrestrial climate, phenology, and human life. The concept of Tianren Xiangying (correspondence between heaven and human) serves as the theoretical foundation linking Wuyun Liuqi with innate constitutional endowment, as Wuyun Liuqi affects fetal development and governs growth during the gestational period, thereby shaping an individual's congenital constitution. The moment of birth thus holds unique significance for life trajectory. While grasping the annual climatic baseline is essential, understanding the Kezhu Jialin (guest and host qi interactions) across the six seasonal steps proves particularly crucial for comprehending a patient's constitutional predisposition, disease occurrence and treatment strategies at specific temporal junctures. Analysis of Wuyun Liuqi pathogenesis involves a comprehensive integration of multiple factors—including the patient's disease characteristics, time of onset, and birth-time Wuyun Liuqi endowment—with particular emphasis on the “phased dominant influence of the six-step guest qi” and the “reinforcement effect of biased endowment when guest qi and host qi share identical nature ” . This paper further integrates clinical case studies to illustrate the application of Wuyun Liuqi-based Sitian Formula (Celestial Commander Formulas) grounded in the principle of Kezhu Jialin and birth-time Wuyun Liuqi endowment.关键词：Huangdi Neijing （Yellow Emperor's Inner Canon）;Wuyun Liuqi （Five Circuits and Six Qi）;birth time;constitutional endowment;Sitian Formula （Celestial Commander Formula）44|65|0<引用本文> <批量引用>更新时间：2026-06-01Special Topic Research
摘要：Professor Gu Zhishan proposed the concept of “Six Meridian Correlated Times. ” This theory is grounded in the Opening, Closing, and Pivoting (Kai-He-Shu) theory presented in Huangdi Neijing, and integrates the temporal positioning of “Six Meridians Resolution Times” from Shanghan Lun. On this basis, he established a pattern differentiation framework encompassing three dimensions： time, space, and constitution. Guided by the theory of Six Meridian Correlated Times, particular attention is given to the temporal node associated with the jueyin Meridian. Within this context, Wumei Pill (Mume Pill) is a representative prescription for regulating jueyin and harmonizing its qi transformation. Its specific application can be understood from several aspects： the daily temporal rhythm, emphasizing treatment based on the optimal recovery times; the annual cyclical rhythm, referring to the dominance of annual qi, Sitian and Zaiquan; the temporal dynamics of disease development, reflected in the sequential transmission of disorders under the Opening, Closing, and Pivoting mechanism; and the temporal formation of constitution, associated with prenatal influences of Five Circuit and Six Qi as well as innate endowment. Furthermore, the clinical application of Wumei Pill guided by the Six Meridian Correlated Times theory is illustrated with representative clinical cases.关键词：Six Meridian Correlated Times;Wumei Pill;Gu Zhishan;exterior-interior relationship of jueyin and shaoyang34|23|0<引用本文> <批量引用>更新时间：2026-06-01Special Topic Research
摘要：The theory of Biaoben Conghua (transformation of the root and branch) elucidates the direction of conformity of the Six Qi during changes in qi transformation. It clearly identifies cold, fire, heat, and dampness as the dominant qi transformation attributes among the Six Qi. This understanding provides diagnostic and therapeutic insights for complex or seemingly contradictory manifestations of qi transformation elements commonly encountered in clinical practice guided by Yunqi theory. It emphasizes that qi transformation encompasses both the normative zhihua (transformation) of the Six Qi and potential zhibian (changes). These changes can manifest as conformity to the ben (root, maintaining the characteristic of the original qi), conformity to the zhong (middle, transforming into another qi, such as retaliatory qi), or conformity to biaoben (superficies and root, combining the original qi with another). Therefore, Circuit-Qi clinical analysis should not rigidly adhere to the transforming qi of the ruling season. Instead, it necessitates comprehensive diagnosis using the four examinations, prioritizing the patient's chief complaint and the qi transformation tendencies reflected in the tongue and pulse. This allows differentiation between disease mechanisms stemming from the normative qi transformation pattern and those arising from zhibian in qi transformation, which present seemingly intricate yet traceable signs. Treatment strategies based on Circuit and Qi principles can then be formulated. This article illustrates clinical application of Sanyin Sitian Formulas based on biaoben conghua through validated case studies.关键词：five circuits and six qi;biao, ben, and zhong qi;conformity of the root and superficies;Sanyin Sitian Formulas;Fuzi Shanyu Decoction;Beihua Decoction26|23|0<引用本文> <批量引用>更新时间：2026-06-01Clinical Research
摘要：Objective To investigate the clinical efficacy of Xingpi Jieyu Formula (Spleen-Awakening and Constraint-Relieving Formula) in the treatment of depression-related insomnia (DRI) and its effects on serum melatonin (MT), glutamate (Glu), and γ-aminobutyric acid (GABA) levels. Methods Randomized double-blind double-dummy parallel positive-controlled study. 90 DRI patients were randomly divided into the Western medicine group (n = 45) and the TCM group (n=45). The patients in the Western medicine group were given esiciprom oxalate tablets and Xingpi Jieyu Formula Granule placebo, and those in the TCM group were given Xingpi Jieyu Formula Granules and escitalopram oxalate tablet placebo. Both groups were treated for 8 weeks. The changes of Hamilton Depression (HAMD) score, Pittsburgh Sleep Index (PSQI) score, TCM pattern score, and serum MT, Glu, GABA levels were recorded before and after treatment of the two groups, and and the Glu/GABA ratio was calculated. Results After treatment, the total effective rate was 84.44% in the TCM group and 71.11% in the Western medicine group. The differences between the groups were not statistically significant (P ＞ 0.05). After treatment, the scores of HAMD, PSQI and TCM pattern scale were significantly lower than before treatment (P ＜ 0.05), but there was no statistical difference between the groups (P ＞ 0.05). After treatment, the sleep quality, sleep time and daytime dysfunction of the two groups were significantly improved (P ＜ 0.05), sleep disorders and the use of hypnotic drugs were also improved (P ＜ 0.05), while the improvement in sleep time and sleep efficiency was not obvious (P ＞ 0.05); the factors of sleep between the groups were compared and there is no difference (P ＞ 0.05). In terms of serum indicators, the serum MT level increased significantly after treatment in the TCM group (P ＜ 0.05), and the Glu/GABA ratio decreased significantly (P ＜ 0.05); only the Glu/GABA ratio in the Western medicine group decreased significantly (P ＜ 0.05); There was no significant change in the average serum Glu and GABA after treatment of the two groups (P ＞ 0.05); there was no statistical difference between the comparison of MT, Glu, GABA and Glu/GABA groups after treatment (P ＞ 0.05). Conclusion Xingpi Jieyu Formula demonstrates efficacy equivalent to Escitalopram Oxalate Tablets in treating DRI. It significantly improves sleep quality and alleviates depressive mood in DRI patients. The therapeutic mechanism involves elevating serum MT levels and reducing the Glu/GABA ratio, thereby restoring excitation/inhibition balance in the central nervous system.关键词：Xingpi Jieyu Formula;depression-related insomnia;melatonin;glutamic acid;γ-aminobutyric acid38|18|0<引用本文> <批量引用>更新时间：2026-06-01Clinical Research
摘要：Objective This study aimed to evaluate the efficacy and safety of Wenyang Sanhan Qushi Formula (Yang-Warming, Cold-Dissipating, and Dampness-Dispelling Formula, WYSHQSF) for persistent HR-HPV infection manifesting yang deficiency with cold-damp obstruction pattern. Methods In this prospective, randomized, open-label, parallel-group clinical trial conducted at Beijing Anzhen Hospital between May and November 2024, we enrolled 126 women aged 24-77 years with persistent HR-HPV infection lasting ≥12 months, characterized by the yang deficiency with cold-damp obstruction pattern. Participants were randomly assigned 1 ∶ 1 to receive either WYSHQSF combined with lifestyle intervention alone (n = 63) or lifestyle intervention alone (n = 63). The primary outcome was overall HPV clearance efficacy rate at 6 months, defined as complete viral clearance or significant reduction in detectable subtypes. Secondary outcomes included subtype-specific clearance rates across 12 HR-HPV genotypes, cytological normalization among participants with abnormal baseline TCT result, and comprehensive safety monitoring.Results Among 106 participants completing the study (54 in the treatment group, 52 in the control group), baseline characteristics were well-balanced. The treatment group demonstrated significantly superior overall efficacy compared to controls (77.8% vs. 42.3%; P = 0.0004), with markedly higher complete viral clearance rates (66.7% vs. 32.7%). TCT normalization rates among participants with abnormal baseline cytology were significantly higher in the treatment group (42.3% vs. 11.5%, P = 0.026 6). Moreover, subtype-specific analyses revealed consistently higher clearance rates across most HR-HPV genotypes, with complete clearance achieved for HPV 39, 58, and 66.No serious adverse events were reported in either group.Conclusion WYSHQSF achieved significantly superior HPV clearance efficacy compared to lifestyle intervention alone, with excellent safety profiles. These findings provide alternatives for women seeking non-invasive options.关键词：human papillomavirus;persistent infection;traditional Chinese medicine;herbal medicine;randomized controlled trial31|4|0<引用本文> <批量引用>更新时间：2026-06-01Clinical Research
摘要：Objective To systematically evaluate the clinical efficacy and safety of Tongmaining Formula in treating patients with arteriosclerosis obliterans presenting with vessel collateral blood stasis pattern. Methods A randomized controlled design was used. 104 ASO patients were randomly divided into a treatment group and a control group, with 52 cases in each group. The treatment group received oral TMNF formula, while the control group received oral Beraprost Sodium tablets. The treatment course was 4 weeks for both groups. Clinical efficacy, lower limb symptom and sign scale scores, foot skin temperature difference, claudication distance and relief time, lipid levels, routine blood tests, and liver and kidney function were observed, and adverse events were recorded. Results The clinical efficacy of the treatment group was superior to that of the control group (P ＜ 0.05). After treatment, the scores of lower limb symptoms, foot skin temperature, claudication distance, and relief time in the treatment group were all significantly improved compared to those before treatment (P ＜ 0.05). In the control group, the lower limb symptom scores and foot skin temperature were improved compared to those before treatment (P ＜ 0.05). The degree of improvement in lower limb symptom scores and claudication distance after treatment was significantly greater in the treatment group than in the control group (P ＜ 0.05). After treatment, no significant abnormal changes were observed in lipid levels, routine blood tests, or liver and kidney function in either group, and there were no statistically significant differences between the two groups (P ＞ 0.05). No drug-related adverse reactions occurred in either group. Conclusion Tongmaining Formula is safe and effective in treating arteriosclerosis obliterans with the vessel collateral blood stasis pattern.关键词：Tongmaining Formula;arteriosclerosis obliterans;intermittent claudication;vessel collateral blood stasis;traditional Chinese medicine treatment34|11|0<引用本文> <批量引用>更新时间：2026-06-01Clinical Research
摘要：Objective To explore the correlation between physical activity and kidney-yang deficiency and cognitive function in patients with vascular cognitive impairment with kidney-yang deficiency. Methods 120 patients diagnosed with vascular cognitive impairment with kidney-yang deficiency were enrolled, physical activity information was collected, and the Montreal Cognitive Assessment Scale (MoCA) was used to assess cognitive function. Spearman correlation analysis was performed to investigate the correlation between physical activity and kidney-yang deficiency and cognitive function. Results Time spent walking at work (r = -0.217, P = 0.018) and walking outside (r = -0.201, P = 0.033) per week were negatively correlated with kidney-yang deficiency syndrome scores, and time spent out in the car (r = 0.308, P = 0.001) and moderate physical housework (r = 0.196, P = 0.035) per week were positively correlated with MoCA scores. Conclusion Physical activity may have the potential to improve kidney-yang deficiency and protect cognitive function. Within specific classifications, walking at work and walking outside may be more closely associated with improvement of kidney-yang deficiency, and going out by car and moderate physical housework may be more closely associated with protection of cognitive function.关键词：vascular cognitive impairment;kidney-yang deficiency;physical activity;cognitive function22|3|0<引用本文> <批量引用>更新时间：2026-06-01Clinical Research
摘要：Objective To explore an accurate and simple surface localization method for Shaofu (HT8), in order to solve the localization deviation problem caused by individual differences and reliance on personal experience in conventional acpoint selection method. Methods By searching TCM classics and modern literature, we sorted out the location descriptions of Shaofu; ② According to the positioning description in the classics, we press the meridians until the point with the strongest sensation is marked on the skin. ③ Pictures were taken of the palm prints of the subjects and patterns around Shaofu were analyzed. ④ We examined whether there are specific two-dimensional palmprint marks on the surface projection points of Shaofu and its vicinity. ⑤ If there are specific palmprint marks, the consistency between the specific palmprint marks and the surface projection of Shaofu were verified. Results According to the location description of Shaofu in ancient books, points with a strong acupoint sensation and relatively fixed can be traced and pressed in the depressions between the fourth and fifth metacarpal bones. ② 98.8% of the hands have a palmprint fork at the projection of Shaofu on the body surface- the point where the transverse palmprint and the thenar eminorium intersect. ③ When we pressed along the intersections of the palm lines on the hand, and 100% of the subjects felt a strong acupoint sensation. Conclusion The palmprint crossover points are the surface projection points of Shaofu, and they can be used as markers to quickly and accurately locate the acupoint.关键词：Shaofu acupoint;body surface positioning;horizontal lines in the palm;hypothenar pattern;palmprint crossover points25|14|0<引用本文> <批量引用>更新时间：2026-06-01
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0 7 Prof. Lyu Peiwen’s experience in treating TCM surgical diseases with drug pairs
10 ZHANG Zhiyuan’s experience in using Minor Center-Fortifying Decoction
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