HAN Hai-xiao1,LI Jun-xiang1,YANG Jin-xiang2,et al.
Vol. 0, Issue 1, Pages: 1-5(2007)
摘要:Objective To study the apoptosis-promoting effect of dog serum of extract from Radix Paeoniae Rubra on hepatic stellate cells(HSC-T6) in the dog model.Method The hepatic stallate cells(HSC-T6) were taken as the model in vitro established by using acetaldehyde.The Radix Paeoniae Rubra extract was given to dog orally once only.The serum samples were taken before giving Radix Paeoniae Rubra extract,2 and 3 hours after giving Radix Paeoniae Rubra extract respectively.The apoptosis-promoting effects of these serum samples(in 2 % concentration) on HSC-T6 after 72 hours in the model were detected by flow cytometry.Result The serum sample promote obviously HSC-T6 apoptosis in 2 hour group and 3 hour group.The apoptosis rate was increased remarkably compare with that of the blank group(P<0.05) The proportion of HSC-T6 in G0/G1 phase were raised obviously in 2 hour group and 3 hour group(P<0.05) ,while reduced in S phase(P<0.05) .There were no any changes in G2/M phase.Conclusion The serum samples of Radix Paeoniae Rubra extract all have obvious apoptosis-promoting effects in two time points,raise the proportion of HSC-T6 in G0/G1 phase and reduce in S phase,which may be the mechanism of Radix Paeoniae Rubra extract for inhibiting HSC-T6 proliferation and promoting HSC-T6 apoptosis.
摘要:Objective To investigate the influence of Yudanrongxin Pills on immunoregulation in mice.Method The mice were randomly divided into the normal group,cyclophosphamide(Cy) model group,huangqi group and Yudanrongxin Pills group.The effects of Yudanrongxin Pills were observed respectively on the phagocytosis of macrophage in mouse abdomen,delayed-type hypersensitivity(DTH) induced by dinitrochlorobenzene(DNCB) ,and generation of hemolysin antibody induced by chicken red blood cell(CRBC) .Result In Yudanrongxin Pills group,compared with the Cy model group,the phagocytosis of macrophage was promoted(P<0.01) ,DTH induced by DNCB was enhanced(P<0.01) and the level of hemolysin antibody was increased(P<0.01) .Conclusion Yudanrongxin Pills has the promotive effect on nonspecific and specific immunity in mice with hypoimmunity induced by Cy.
关键词:Yudanrongxin Pills;immunity;mice;experimental study
摘要:Objective To evaluate the curative effect of Qihong Decoction on idiopathic pulmonary fibrosis.Method The patients with idiopathic pulmonary fibrosis(n=60) were randomly divided into the treatment group and control group(each n=30) .The treatment group was given Qihong Decoction orally and the control group was treated with prednisone orally.Two groups were observed for 3 months.Result The total effective rate was 73.33 % in the treatment group and 43.33 % in the control group.The symptom total integral,integrals of asthma,cough and Velcro rale were decreased more obviously in the treatment group than those in the control group.The lung diffusing capacity and blood oxygen saturation were increased,and the reinfection cases were less in the treatment group than those in the control group.Conclusion Qihong Decoction has a better effect than the control medication on idiopathic pulmonary fibrosis and is more safe.
关键词:idiopathic pulmonary fibrosis;Qihong Decoction;replenishing qi and activating blood aiculation;resolving phlegm to dredge collaterals
摘要:Objective To observe the curative effect and safety of Ganzhixiao Capsules on nonalcoholic fatty liver and discuss the mechanism.Methods The cases of nonalcoholic fatty liver(n=120) were chosen,and divided randomly into the treatment group(n=60) and the control group(n=60) ,whose TCM syndrome types were syndrome of superabundance of dampness due to spleen insufficiency,phlegm-heat and blood stasis,and meridians stagnation.The treatment group was treated with Ganzhixiao Capsules and the control group with Dongbaogantai Tablets orally for 90 days respectively.The TCM symptom integral,liver function,blood lipid level and examination of B type ultrasonography were observed in two groups.Results In the treatment group the total effective rate of symptoms was 95.0 %(P<0.05 comparing between two groups) .The changes of blood lipit level,serum transaminase and imaging of fatty liver were obvious in two groups.The result of the treatment group was better than that of the control group(P<0.01) in symptom relief and imaging changes.Conclusion Ganzhixiao Capsules has a good curative effect on nonalcoholic fatty liver without obvious toxic and side effects.The mechanism is mainly that Ganzhixiao Capsules can invigorate spleen to resolve dampness,clear away heat to eliminate dampness,and activate blood to dredge collaterals.
关键词:Ganzhixiao Capsules;nonalcoholic fatty liver;evaluation of curative effect
摘要:Objective To study the clinical effect of TCM syndrome differentiation and treatment on radiation esophagitis.Method All 144 cases of radiation esophagitis were randomly divided into the treatment group and control group.Besides the routine treatment,the treatment group was treated according to TCM differentiation and classification,and the control group was treated with hormone therapy.The alleviation of some symptoms,such as dysphagia,retrosternal pain,saliva spitting,burning sensation and pain with eating,were observed.Result After the treatment there was no obvious difference in some symptoms like dysphagia,retrosternal pain and saliva spitting between two groups(P>0.05) ,while in burning sensation and pain with eating the disappearing rate in the treatment group was obviously higher that that in the control group(P<0.05) .Conclusion The curative effect of TCM syndrome differentiation and treatment is better than that of hormone therapy on radiation esophagitis.
关键词:radiation esophagitis;TCM syndrome differentiation and treatment;hormone
摘要:Objective To study the effect of Feixinqing Capsules on chronic pneumocardiopathy in acute seizure phase.Method All 240 cases were randomly divided into the treatment group and control group.The treatment group was treated with Feixinqing Capsules besides the routine treatment of western medicine and the control group with the routine treatment only.The treatment course was 4 weeks.The curative effects were observed and compared in two groups.Result The curative effect of the treatment group was better than that of the control group.The improvement of hemorrheology and PaO2,and recovery of liver and kidney injury in the treatment group were better than those in the control group too.Conclusion Feixinqing Capsules is effective and safe used in treating acute seizure phase of chronic pneumocardiopathy.
关键词:chronic pneumocardiopathy;acute seizure phase;integration of Chinese and Western medicine;Feixinqing Capsules;curative effect
摘要:Objective To study the change law of TCM syndromes before and after the treatment of non-small cell lung cancer with cryotherapy of argon-helium superconductive operation system.Method The TCM syndrome changes and law in patients before and after the operation were observed and summed up by using the prospective study method.Result The phlegm and deficiency syndrome became less 2 weeks after the operation and blood stasis syndrome had no changes.The syndromes of phlegm-dampness,blood stasis and qi-insufficiency were still observed after the operation.Conclusion The syndromes of phlegm,blood stasis and deficiency are main pathogenesis of metaphase and late non-small cell lung cancer.The cryotherapy of argon-helium superconductive operation system is one of effective therapies for relieving TCM syndromes.The syndromes of phlegm,blood stasis and deficiency observed after the operation indicates that the therapies of resolving phlegm,activating blood circulation and strengthening healthy qi should be applied according patient’s conditions after the operation to remove latent phlegm and blood stasis,enhance the curative effect and prevent the patient from the recurrence and metastasis of non-small cell lung cancer.
摘要:Objective To observe the curative effect of the therapy of tonifying kidney,activating blood circulation and relieving depression on rheumatoid arthritis(RA) combined with depressive disorders(TCM syndrome of kidney deficiency and blood stasis) .Methods The random and control principle was applied to choose 66 patients according to the standards of rheumatoid arthritis,depression and TCM syndromes.The patients were divided into the treatment group treated with Bushenhuoxuejieyu Formula(1 dose/d) ,and the control group treated with Fluoxetine Capsules(20 mg/d) on the basis of routine antirheumatic therapy.After 6 weeks the influences of Bushenhuoxuejieyu Formula on depression and RA were observed.Results ① The score of HAMD showed that the total effectual rate and effective rate was 79.41 % and 88.24 % respectively in the treatment group,and 62.50 % and 81.25 % in the control group.The comparison between two groups showed that P>0.05.② According to the relief of RA the total effectual rate and effective rate was 79.41 % and 91.18 % respectively in the treatment group,and 71.88 % and 87.50 % in the control group.The comparison between two groups showed that P>0.05.Conclusion One of the pathogeneses of RA combined with depressive disorders is kidney deficiency,blood stasis and cerebral spirit exhaustion.The therapy of tonifying kidney,activating blood circulation and relieving depression can relieve depressive disorders and alleviate rheumatoid arthritis.
关键词:rheumatoid arthritis;depressive disorders;tonifying kidney,activating blood circulation and relieving depression
摘要:Objective To discuss the clinical curative effect of the therapy of ascending lucidity,descending turbidity and activating blood on pulmonary fever of warm disease.Method All 36 patients with fever induced by simple influenza(syndrome of exterior wind-heat in TCM) were randomly divided into the treatment group and control group.The treatment group was treated with the therapy of ascending lucidity,descending turbidity and activating blood and the control group with Antivirus Oral Solution.The effects of these treatments on patient body temperature within 3 days were observed.Result After the treatment the patient body temperature was decreased obviously(P<0.05) in the treatment group.The total effective rate was 88.89 % in the treatment group and 83.34 % in the control group.The difference in two groups was not significant(P>0.05) .Conclusion The therapy of ascending lucidity,descending turbidity and activating blood is an effective febrifugal therapy.It has a similar clinical effect with Antivirus Oral Solution on fever of influenza(syndrome of exterior wind-heat in TCM) .
关键词:the therapy of ascending lucidity,descending turbidity and activating blood;warm disease;fever of pulmonary system;influenza