摘要:Objective To find out the protective mechanism of Buyanghuanwu Decoction for antagonizing senile cerebral ischemia-reperfusion lesion on the base of expression changes of tumor necrosis factor-α (TNF-α),intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). Method The animal model of cerebral ischemia was established by using middle cerebral artery occlusion (MCAO). The nervous symptom scores,brain water content and pathological changes,and the expressions of TNF-α,ICAM-1,VCAM-1 and ICAM-1mRNA were observed after ischemia for 3 hours,and ischemia-reperfusion lesion for 1,3,6 and 12 days respectively. Result In the model group the brain water content (ischemia-reperfusion for 1,3 and 6 days),nervous symptom scores (at all time points),expressions of TNF-α and VCAM-1 (ischemia for 3 hours,ischemia-reperfusion for 1,3 and 6 days),ICAM-1 (ischemia for 3 hours,ischemia-reperfusion for 1,3 and 6 days) and mRNA (at all time points) were all higher than those in the sham-operation group. In the Buyanghuanwu Decoction group the nervous symptom scores and brain water content (ischemia-reperfusion for 3,6 and 12 days),the expressions of TNF-α,VCAM-1,ICAM-1 and mRNA (ischemia for 3 hours,ischemia-reperfusion for 1 and 3 days) were all lower than those in the model group. In the Buyanghuanwu Decoction group the nervous symptom scores (ischemia-reperfusion for 6 and 12 days),the expressions of TNF-α (ischemia-reperfusion for 1 day),ICAM-1 (ischemia-reperfusion for 1 day) and mRNA (ischemia-reperfusion for 1 and 3 days) were all lower than those in the nimodipine group. Conclusion The mechanism of Buyanghuanwu Decoction for antagonizing senile cerebral ischemia-reperfusion lesion may be related to its inhibitory effect on the expressions of TNF-α,ICAM-1 and VCAM-1.
摘要:Objective To study the influence and mechanism of Heweixiaopi Capsules (HC) on rat electrogastrogram. Method The model of kinetic disorder of gastrointestine was established in rats by fasting every other day,and then the electrogastrogram were detected respectively in normal and the model rats. The percentage of slow wave of normal gastric electric rhythm and main power were analyzed. Result The percentage of slow wave of normal gastric electric rhythm and main power were all increased after HC administration in normal rats and the groups with different doses of HC,and those was the most significant in the group with medium-dose of HC. There was a significant difference between the group with medium-dose of HC and normal control group (P<0.05). The percentage of slow wave of normal gastric electric rhythm was decreased obviously in the model group after HC administration (P<0.05). Conclusion HC can increase the percentage of slow wave of normal gastric electric rhythm in normal rats,prevent abnormal gastric electric rhythm in rats out of normal diet. It can regulate gastric electric rhythm,which may be one of its mechanisms of regulating gastric kinetic function.
WANG Tong1,GUO Xia-zhen1#,YANG Wei-bin2,YANG Hua-yan2
Vol. 0, Issue 4, Pages: 7-9(2008)
摘要:Objective To investigate the connotation of TCM theory of kidney dominating bones and kidney corresponding to winter through the changes of kidney function and biochemical indexes in patients with renal bone disease in winter and summer. Method The patients with chronic renal failure (CRF) and uraemia were taken as the observational objects,and their indexes of kidney function,biochemistry and routine blood tests were detected and compared in winter and summer. Result The levels of creatinine (CREA) and blood urea nitrogen (BUN) and parathormone (PTH) were higher than the normal values significantly in the patients with a seasonal trend of higher in winter and lower in summer. The comparison in BUN levels between winter and summer had a significant difference (P<0.05). The level of hemoglobin (Hb) was lower than the normal value in winter and summer. The comparison in phosphate(P) levels between winter and summer had no significant difference (P>0.05). Conclusion The seasonal changes of kidney functional indexes is helpful to the prevention and treatment of renal bone disease in clinic based on TCM theory of treatment in accordance with seasons.
关键词:renal bone disease;seasonal changes;kidney function;kidney corresponding to winter;kidney dominating bones
摘要:Objective To observe the curative effect of Shenqiong Glucose Injection on nephritic syndrome and its influence on hemorheology. Method All 86 patients with nephritic syndrome were randomly divided into the treatment group treated with Shenqiong Glucose Injection and routine treatment,and the control group treated with routine treatment. After 2 treatment courses the evaluation of curative effect was made according to urine protein ration and hemorheological indexes were determined. Result The total effective rate was 86.0 % in the treatment group and 65.1 % in the control group. The treatment group had a significantly higher effective rate than the control group (P<0.05),and some hemorheological indexes decreased obviously,such as the whole blood viscosity,plasma viscosity,aggregation index and ESR (P<0.05). There was a significant difference between two groups after the treatment (P<0.05). Conclusion The administration of Shenqiong Glucose Injection on the base of the routine treatment can relieve the hypercoagulable state,hemorheological disorder and symptoms,reduce urine protein,and improve kidney function with a better curative effect in the patients with nephritic syndrome.
摘要:Objective To investigate the improvement of knee function by small needle knife in the patients with knee osteoarthritis and the difference among different TCM syndrome types,and to standardize the treatment of knee osteoarthritis with small needle knife. Method The patients with knee osteoarthritis were chosen,and their functional indexes were observed and compared according to TCM syndrome types before and after the treatment. Result Small needle knife had obvious effect of improvement on functional indexes of knee joint,and there was no difference among different TCM syndrome types. Conclusion Small needle knife can improve the function of knee joint to a certain extent in the patients with knee osteoarthritis.
关键词:small needle knife;knee osteoarthritis;function of knee joint;clinical observation
摘要:Objective To observe the curative effect of acupuncture on dysphagia induced by ischemic stroke. Method The hospitalized patients (n=60) were randomly divided into the control group (n=30) and acupuncture group (n=30). The control group was given routine treatment and rehabilitation training,and the acupuncture group was given needling therapy of restoring consciousness,opening orifices,soothing throat and improving deglutition besides routine treatment and rehabilitation training. Result After 15 and 30 days the difference in deglutition between two groups was significant (P<0.05). The outcomes of the acupuncture group were better than those of the control group. Conclusion Acupuncture has a good curative effect on dysphagia induced by ischemic stroke.
摘要:Objective To observe the curative effect of JIANG Chun-hua’s Modified Jiechun Formula on bronchial asthma in acute seizure phase. Method The patients (n=67) were randomly divided into the treatment group (n=37) treated with routine western medicinals combined with JIANG Chun-hua’s Modified Jiechun Formula,and the control group (n=30) treated with routine western medicinals. A treatment course was for 2 weeks and the patients were observed for two treatment courses. Result The total effective rate was 91.89 % in the treatment group and 73.33 % in the control group. The difference was significant between two groups (P<0.05). Conclusion JIANG Chun-hua’s Modified Jiechun Formula combined with routine western medicinals has a better curative effect on bronchial asthma in acute seizure phase than only routine western medicinals.
摘要:Objective To observe the curative effect of the therapy combined cooling and warming on chronic atrophic gastritis. Method The treatment group (n=42) was treated with Banxiaxiexin Decoction of ZHANG Zhongjing’s and the control group (n=32) with western routine treatment. Result In the treatment group the total effective rates in symptoms and pathological changes were respectively 92.86 % and 71.43 %,while in the control group,78.12 % and 53.13 %. There was a significant difference between two groups (P<0.05). In the treatment group some symptoms,including stomachache,eructation,poor appetite and fatigue,were relieved more obviously than in the control group (P<0.05). Conclusion The therapy combined cooling and warming has a reliable curative effect on chronic atrophic gastritis.
关键词:chronic atrophic gastritis;epigastric fullness syndrome;therapy combined cooling and warming
摘要:Objective To observe the curative effect of preventive treatment with Chinese medicinals on vaginal bleeding after induced abortion. Method The patients (n=298) were divided into the treatment group (n=157) treated with Shenghua Decoction combined with Culuanpofayu Decoction,and the control group (n=141) treated with Shenghua Decoction only for 10 days as one treatment course. The patient conditions of two groups were observed before and after the treatment. Result The average bleeding days of the treatment group was 9.48 days and of the control group,14.31 days. There was a significant difference (P<0.05) between two groups. Conclusion Shenghua Decoction combined with Culuanpofayu Decoction can shorten the vaginal bleeding period after induced abortion.