BAI Hua~1,LI Zhong~1,CHEN Wei-wu~2,ZHONG Xing~1,Zhang Ya-yue~1
Vol. 16, Issue 2, Pages: 1-5(2009)
摘要:Objective To study the effect and mechanism of Qizhengxiaotong Emplastrum for relieving cancer pain by using cancer pain model.Methods The model of cancer pain was established in mice with lung or femoral cancer.All mice were divided into the treatment group,control group,model group and blank group.The treatment group was given Qizhengxiaotong Emplastrum(0.75 g/kg),and the model group and blank group were given normal saline solution(0.5 mL/each)externally for 5 days on 10th day after the establishment of model.The control group was given the intramuscular injection of sulfuric tetrahydropalmatine(6.498 mg/kg)on the 14th day after model established.The pain behaviors including mechanical pain sensitivity and thermal hyperalgesia were measured in mice of all groups after the last drug administration.The X-ray radiography was used in mice on the femurs for the imaging evaluation of bone destruction.The immunohistochemistry method was used to detect the levels of tumor necrosis factorα(TNFα),endothelin(ET-1)and interluking-1β(IL-1β)in focal skin tissue,and the expressions of positive neurons of the spinal dorsal horn including SP-R,c-fos and GFAP in all goups.Results On the 14th day the percent of paw withdrawal response induced by Von Frey fibers(2g)was decreased significantly in the treatment group compared with that in the model group(P<0.01).The thermal analgesic latency was prolonged significantly in the treatment group than that in the control group(P<0.01).The result of X-ray radiography showed that bone destruction alleviated,radiological assessment decreased,and the inflammatory mediators of focal skin tissue and relevant positive neuron expressions reduced significantly.Conclusion Qizhengxiaotong Emplastrum is effective to mouse with cancer pain,and it can relieve pain behaviors and delay bone destruction.The analgesia mechanism may be related to the role played by peripheral and central mechanisms together.
摘要:Objective To observe the influences of Tangluoning Oral Solution(TOS)on the general indexes and cold or heat stimulations in rats with diabetes induced by streptozotocin(STZ).Method The rat model of diabetes was established by the induction of STZ,and then all rats were divided into the model group,Western drug group,TOS group 1(with high dose of TOS),TOS group 2(with medium dose)and TOS group 3(with low dose).After the treatment the influences of TOS on general indexes and cold or heat stimulations in rats with diabetes were observed.Result Comparing with the normal control group,the level of glycated hemoglobin increased significantly in the model group and decreased in TOS group 2 and 1(P<0.05).The blood sugar level increased in the model group and decreased in TOS group 2 and 1.The rat weight unchanged in TOS group 1,2 and 3(P>0.05).In the model group the responses to cold and heat stimulations showed a diphasic change from hyperalgesia to hypoalgesia,while in TOS group 1,2 and 3 hyperalgesia and hypoalgesia were relieved.Conclusion TOS can decrease the levels of glycated hemoglobin and blood sugar,and it can also relieve the peripheral neuropathy in rats with diabetes induced by STZ.
关键词:Tangluoning Oral Solution;rats with diabetes;response to cold stimulation;response to heat stimulation;rats
摘要:Objective To study the influence of Kangxianyi’ai Formula on metabolism of extracellular matrix in rats with liver fibrosis, and discuss the mechanism of its effect of anti-fibrosis.Methods The rat model of liver fibrosis was established by using diethylnitrosamine.Fufangbeijiaruangan Tablets and colchicine were taken as the control drugs.The influence of Kangxianyi’ai Formula on the histopathological changes of the liver in model rats were observed and the expressions of collagenⅠ,collagenⅣ, MMP-1 and TIMP-1 in rats of different groups were detected by using immunohistochemistry assay.Results In Kangxianyi’ai Formula group the expression of MMP-1 was significantly higher than that in the model control group or Fufangbeijiaruangan Tablets group respectively,the expressions of collagenⅠand TIMP-1 were significantly lower than those in the model control group,and the expression of collagenⅣwas significantly lower than that in the model control group or Fufangbeijiaruangan Tablets group. Conclusion Kangxianyi’ai Formula has significant effect of anti-fibrosis,and the mechanism may be related to that it can increase the expression of MMP-1,decrease the expression of TIMP-1,promote the degradation of extracellular matrix and reduce the aggradation of collagen.
摘要:Objective To study the relationship between TCM syndromes and high-sensitivity C-reactive protein(Hs-CRP).Method The patients with stroke(n=48)were divided into groups according to the level of Hs-CRP,TCM syndromes,onset time and carotid plaque status,and the relevant data were analyzed,dealt with and compared.Result There was significant difference in Hs-CRP, wind syndrome,fire-heat syndrome and phlegm syndrome,and there was difference in qi-deficiency syndrome between stroke in acute stage and in convalescence.There was difference in NIHSS of stoke in acute stage and blood-stasis syndrome of stroke in convalescence respectively between the normal group(with normal Hs-CRP)and abnormal group(with abnormal Hs-CRP).There was difference in Hs-CRP of yin-deficiency syndrome of stroke in acute stage and phlegm syndrome of stroke in convalescence between the normal group and abnormal group.Hs-CRP was correlated significantly to phlegm syndrome of stroke in convalescence.There was a statistical correlation between NIHSS and Hs-CRP of stroke in acute stage or convalescence.There was a statistical correlation between Hs-CRP of stroke in acute stage and yin-deficiency syndrome of stroke in convalescence or NIHSS.The influences of the formation of carotid plaques on Hs-CRP were different.Conclusion In the abnormal group of stroke in convalescence the blood-stasis syndrome is more serious than that in the normal group.Hs-CRP is higher in patients with yin-deficiency syndrome of stroke in acute stage or phlegm syndrome of stroke in convalescence than that in patients without definite diagnosis.Hs-CRP of stroke in convalescence is correlated significantly to phlegm syndrome.The yin-deficiency syndrome of stroke in convalescence and neurological deficits were more serious in the patients with a higher Hs-CRP of stroke in acute stage.
摘要:Objective To observe the curative effect of the therapy of resolving phlegm and relaxing bowels on the disturbance of consciousness in patients with stroke involving zang-fu.Method The autogenic antero-posterior control method was used to analyze the relationship between consciousness and fu-qi on the base of treatment with the therapy of resolving phlegm and relaxing bowels combined with Chinese and Western therapies.The changes of fire-heat-phlegm syndrome and influence of the time of consciousness disturbance on patients with stoke involving zang-fu were compared.Result Relaxed fu-qi relieved consciousness disturbance and alleviated fire-heat-phlegm syndrome,and the time of consciousness disturbance was shortened after the application of the therapy of resolving phlegm and relaxing bowels.Conclusion The therapy of resolving phlegm and relaxing bowels can promote the recovery of the consciousness in patients with stroke.
关键词:stroke;stroke involving zang-fu;consciousness disturbance;therapy of resolving phlegm and relaxing bowels
摘要:Objective To observe the influence of acupuncture combined with eyedrops on the intraocular pressure in the patients with primary open-angle glaucoma and difference of curative effects between this therapy and eyedrops.Method The patients with primary open-angle glaucoma(n=49,86 eyes)were randomly divided into the treatment group treated with acupuncture combined with eyedrops and the control group treated with eyedrops only.The indexes of intraocular pressure were detected and compared in the patients of two groups before and after the treatment.Result The intraocular pressure was significantly different in the patients of two groups after the treatment than before(P<0.05).In the treatment group the intraocular pressure in patients after half year was also significantly different after the treatment than before(P<0.05).Conclusion The therapy of acupuncture combined with eyedrops can reduce the intraocular pressure in the patients with primary open-angle glaucoma.
摘要:Objective To discuss and summarize the laws of treatment of Kawasaki disease with integrated medicine of Chinese and Western in clinic.Method The cases accorded with the diagnosis standard were brought into the study.The characteristics of clinical symptoms in these cases were analyzed.The syndrome differentiation of Wei,Qi,Ying and Xue of TCM was given to the cases,which then treated with aspirin and gamma globulin.Result All 30 cases were cured.The average time of body temperature inducing to the normal was(6.5±2.5)days and the average hospitalized period was(21.4±4.5)days.Conclusion Treatment of Kawasaki disease with integrated medicine of Chinese and Western has reliable curative effect,which can reduce cardiovascular complications.
关键词:Kawasaki disease;syndrome differentiation of Wei,Qi,Ying and Xue of TCM;activating blood circulation and removing stasis
摘要:Objective To observe the curative effect of Bushenqiangdu Formula on ankylosing spondylitis(syndrome of kidney deficiency,Du meridian cold and blood stasis).Method The patients(n=30)with ankylosing spondylitis were treated with Bushenqiangdu Formula,and then the clinical symptoms,signs,TCM syndrome manifestations,examinations of C-reactive protein (CRP),erythrocyte sedimentation rate(ESR),6 items of fibrinolysis and platelet in the patients were observed before and after the treatment.Result The clinical symptoms,signs and laboratory indexes were relieved or changed in the patients after the treatment with significant difference compared with those before the treatment.There was significant difference in the comparison of D-dimer (DD),fibrin degradation products(FDP),antithrombin-Ⅲ(AT-Ⅲ)and tissue type plasminogen activator activity(t-PA)before and after the treatment(P<0.05).Conclusion Bushenqiangdu Formula can relieve the symptoms or signs including arthralgia,morning anchylosis,finger to floor distance,occiput wall distance,Schober’s sign,especially the syndrome of blood stasis in the patients with ankylosing spondylitis.
关键词:ankylosing spondylitis;kidney deficiency;Du meridian cold;syndrome of blood stasis
摘要:Objective To observe the curative effect of Xinnaoliantong Capsules combined with Western drugs on angina pectoris of coronary heart disease(CHD).Method The patients with angina pectoris of CHD(n=72)were randomly divided into two groups. The control group was treated with routine Western drugs and treatment group was treated with Xinnaoliantong Capsules on the base of routine Western drugs.After 4 weeks the curative effects were observed in two groups.Result The curative effects on blood-stasis syndrome and angina pectoris were better,and the dosage of sublingual nitroglycerin was reduced in the treatment group than those in the control group.Conclusion The therapy of Xinnaoliantong Capsules combined with Western drugs for treating angina pectoris of CHD is better than the simple therapy of Western drugs.
关键词:angina pectoris;Xinnaoliantong Capsules;integration of Chinese and Western medicine
摘要:Objective To observe the curative effect of the retention enema therapy of Chinese herbal drugs on chronic pelvic inflammation.Method The patients with chronic pelvic inflammation(n=182)were randomly divided into two groups.After anti-inflammation treatment intravenously for one week the treatment group(n=91)was treated with the retention enema therapy of Chinese herbal drugs and the control group(n=91)were treated with oral antibiotics.Result The total effective rate was 79.12%in the treatment group and 26.37%in the control group.There was a great significant difference in the comparison between two groups (P<0.01).Conclusion The retention enema therapy of Chinese herbal drugs has a reliable effect on chronic pelvic inflammation.
关键词:chronic pelvic inflammation;enema therapy of Chinese herbal drugs;Wuweixiaodu Decoction