摘要:Objective To sum up the academic thought and rules of diagnosis and treatment of Professor LV Ren-he for diabetes differentiation and treatment by applying database mining technology,and review the practical prospect of Database of Medical Records of Chinese Medicine.Methods The medical records of 128 patients with diabetes diagnosed and treated by Professor LV Ren-he were collected,and then the data were processed congruously and put into Database of Medical Records of Chinese Medicine.The occurrence rate of types,stages,complications,causes and locations of diabetes after syndrome differentiation based on TCM theory was calculated,and the relation among them was analyzed.Results The diabetes patients treated by Professor LV Ren-he were mostly those of type 2 diabetes with diabetes complications and concomitant diseases.The occurrence rate of diabetic nephropathy was the highest and that of diabetic neuropathy was secondly high.The diet factors,i.e.intaking too much greasy and delicacy food,and motion factors,such as upward of qi due to anger,were important in the onset of diabetes.The disease locations were mainly in kidney and liver.Conclusion The outcomes of data mining from Database of Medical Records of Chinese Medicine reflect objectively the clinical thinking and experience of Professor LV Ren-he,which can be applied in knowledge mining and study of TCM records,and summary of academic thought of experts.
摘要:Objective To discuss the distribution and combination of TCM syndrome differentiation factors in patients with insomnia.Method The factors of TCM syndrome differentiation in 100 patients with insomnia were estimated,and the difference of TCM syndrome differentiation factors between the patients with simple insomnia and those with insomnia accompanied by emotional disorder was compared.Result In 100 patients those with fire-heat syndrome accounted for 92%,blood-deficiency syndrome,for 79%,qi-stagnation syndrome,for 78%,and qi-deficiency syndrome,for 74%.The occurrence rate of above 4 syndrome differentiation factors was all higher than 70%.The combination of 4,5 and 6 factors of syndrome differentiation accounted for 62%.The insomnia accompanied by emotional disorder was related to qi-deficiency syndrome more closely than simple insomnia was.Conclusion The fire-heat syndrome,blood-deficiency syndrome,qi-stagnation syndrome and qi-deficiency syndrome are common syndrome differentiation factors of insomnia.Insomnia has complicated pathogenesis,and the syndrome of deficiency combined with excessiveness is more common.The insomnia accompanied by emotional disorder is correlated to qi-deficiency syndrome.
摘要:Objective To observe the curative effect of Feixian Formula on idiopathic pulmonary fibrosis.Method The patients with idiopathic pulmonary fibrosis (n=40) were randomly divided into the treatment group (n=20) and control group (n=20).The treatment group was treated with Feixian Formula and the control group,with prednisone for 3 months respectively.The curative effect,and the changes of pulmonary diffusion function and blood oxygen pressure were observed before and after the treatment.Result The total effective rate was 84.2% in the treatment group and 81.3% in the control group.The blood oxygen pressure was significantly increased in the treatment group.Conclusion Feixian Formula can be used for treating idiopathic pulmonary fibrosis effectively.
摘要:Objective To observe the curative effect of self-made Xianyangti Formula on infantile adenoid hypertrophy.Method The child patients with infantile adenoid hypertrophy (n=108) were treated with self-made Xianyangti Formula for one month.Result Among 108 cases,there were 82 cases with marked effect,18 with effect and 8 with inefficacy.The effectual rate was 75.93% and the total effective rate was 92.59%.Among 18 cases accompanied by secretory otitis media,the hearing of 13 cases was significantly improved,and 3 cases,slightly improved.Conclusion Self-made Xianyangti Formula has a good curative effect on infantile adenoid hypertrophy.
关键词:children;adenoid hypertrophy;Xianyangti Formula
摘要:Objective To investigate and analyze the administration and clinical control of inhaled remedies in patients with bronchial asthma.Method The questionnaires were used in 98 patients with bronchial asthma with the interview between physicians and patients.Result Among 98 patients 15 cases administrated remedies moderately and regularly,of these 15 cases 11 cases used inhaled glucocorticoid and 4 cases used the complex preparation of inhaled glucocorticoid and long-effective β2-receptor agonist.There 14 cases from above 15 cases had the total control.The educational level was correlated to clinical control of remedies.The causes of intermittent administration of remedies included the factors of physicians and patients.Conclusion The administration of inhaled remedies by the patients with bronchial asthma is unreasonable and at a lower ratio of clinical control.The health education should be strengthened in physicians and patients.
关键词:bronchial asthma;inhaled remedies;clinical control
摘要:Objective To observe the curative effect of Xinglouchengqi Decoction on the phlegm-heat and fu-excess syndrome of ischemic stroke,and discuss the mechanism through detecting changes of high-sensitivity C-reactive protein (Hs-CRP).Method The patients with the phlegm-heat and fu-excess syndrome of ischemic stroke (n=56) were randomly divided into the treatment group (n=28) and control group (n=28).On the base of routine treatment,including the therapy of activating blood circulation and resolving stasis and inhibiting platelet aggregation,the treatment group was given Xinglouchengqi Decoction and control group was given anus injection of Kaiselu to treat astriction.The treatment course was one week.The scores of TCM syndromes,scores of neurological deficits and changes of serum Hs-CRP were observed in two groups before and after the treatment.Result After the treatment the scores of wind syndrome,fire-heat syndrome and phlegm syndrome were different in two groups compared respectively with those in two groups before the treatment.There was a difference in the scores of fire-heat syndrome between two groups.The changes of Hs-CRP were improved more significantly in the treatment group than in the control group.Conclusion Xinglouchengqi Decoction has a better curative effect on the phlegm-heat and fu-excess syndrome of ischemic stroke,and the mechanism may be related to that it can relieve the inflammatory lesion of brain ischemia and improve cerebral circulation.
关键词:Xinglouchengqi Decoction;therapy of resolving phlegm and relaxing bowels;ischemic stroke;high-sensitivity C-reactive protein
AN Chao1,Nong Yi-bing2,Wen Zhi-hao1,Su Jing-ze1,Lin Qian2#
Vol. 16, Issue 3, Pages: 17-19(2009)
摘要:Objective To observe the intervention effect of astragalus saponin or astragalan polysaccharide on mitochondrial membrane potential(MMP)of cardiomyocyte,and investigate initially the mechanism of preventing and treating heart failure by Radix Astragali seu Hedysari.Method The cardiomyocytes were cultured in vitro in neonatal rats,and then divided into the control group(group 1),model group(group 2),astragalus saponin model(group 3),astragalan polysaccharide group(group 4)and astragalus saponin combined with astragalan polysaccharide group(group 5).All groups,except group 1,were given angiotensin Ⅱ(AngⅡ)for establishing the model of hypertrophic cardiomyocyte.Group 3,4 and 5 were intervened by astragalus saponin or astragalan polysaccharide respectively.The MMP of cardiomyocyte was detected in all groups on 24th and 48th hour.Result On 24th hour,MMP decreased in group 2 than that in group 1 with a significant difference(P<0.01),increased in group 3,4 and 5 with a significant difference(P<0.01),and increased in group 3 than that in group 1 with a significant difference(P<0.01).On 48 hour,MMP decreased more significantly in group 2 than that in group 1(P<0.01),increased in group 3,4 and 5,and more significantly in group 3 and 5 than that in group 2 with a significant difference(P<0.01).Conclusion AngⅡ can reduce MMP in cardiomyocytes.Astragalus saponin and astragalan polysaccharide can promote MMP to the normal level,which indicates that astragalus saponin and astragalan polysaccharide can antagonize the MMP decreasing effect of AngⅡ.It may be one of mechanisms of Radix Astragali seu Hedysari for preventing and treating heart failure.
摘要:Objective To investigate the mechanism of Xiaoyinjiedu Decoction and its modified formulas in curing psoriasis through studying the influence of Xiaoyinjiedu Decoction and its modified formulas on vascular endothelial growth factors(VEGF)secreted by keratinocyte COLO-16.Method All SD rats(n=36)were randomly divided into the Xiaoyinjiedu Decoction group(group 1),Qufengchushi Formula group(group 2),Jiedu Formula group(group 3),Liangxue Formula group(group 4),methotrexate(MTX)group(group 5)and control group(group 6).After drugs ministration for 5 days,the medical serum samples were collected from rats of all groups and added into cultured keratinocyte COLO-16.The contents of VEGF secreted by keratinocyte were detected by using double antibody sandwich ELISA.Result Comparing with group 6,when the concentration of medical serum was 5%,the content of VEGF in group 1 and 5 decreased significantly and that in group 1,more significantly(P<0.01).When the concentration of medical serum was 10%,the content of VEGF in group 1,3 and 5 decreased significantly and that in group 1 and 3,more significantly(P<0.01).When the concentration of medical serum was 20%,the content of VEGF in group 1,3,4 and 5 decreased significantly and in group 1,3 and 5,more significantly(P<0.01).Conclusion Xiaoyinjiedu Decoction and its modified formulas,except Qufengchushi Formula,can inhibit VEGF secreted by keratinocyte COLO-16.It may be one of important mechanism of Xiaoyinjiedu Decoction for inhibiting the proliferation of vascular endothelial cells and curing psoriasis.