LUO Yuan-yuan,ZHANG Xiao-ming,Director: LI Chang-qin
Vol. 16, Issue 4, Pages: 1-3(2009)
摘要:Objective To investigate the curative effect and mechanism of Zengsunganluxiaodu Pellets in antagonism of hepatic fibrosis. Methods The rat model of hepatic fibrosis was established by hypodermic injection of carbon tetrachloride and alcohol feeding, and then all rats were divided into 6 groups and given treatment for 8 weeks. The contents of serum precollagen III (PC III) and collagen IV (IV-C) were detected by applying radioimmunoassay. The pathological changes of liver were observed by using collagenic fibre stain (Van-Gieson) and reticular fibre stain (Gomori) and the pathological grading of hepatic fibrosis was carried out. The hyperplasia of reticular fibre was analyzed by using computer imagine analysis system. Results In pathological model group the contents of serum PC III and IV-C increased significantly than those in the normal group (P<0.05). After the treatment the contents of serum PC III and IV-C decreased significantly in high-dose Zengsunganluxiaodu Pellets group, mid-dose Zengsunganluxiaodu Pellets group and Fufangruangan Tablets group than those in the pathological model group (P<0.05). The contents of serum PC III and IV-C were significantly different in high-dose Zengsunganluxiaodu Pellets group and mid-dose Zengsunganluxiaodu Pellets group from those in low -dose Zengsunganluxiaodu Pellets group (P <0.05). Conclusion Zengsunganluxiaodu Pellets can inhibit the generation of extracellular interstitial collagen, decrease the contents of serum PC III and IV-C, relieve significantly hepatic fibrosis, reduce collagenic fibre and reticular fibre, and cure hepatic fibrosis induced by carbon tetrachloride in rats.
LIU Bao-lu1,QUAN Fu-cai1,ZHAO Shu-ling1,LI Jiang-hong1#,LU Yan1,ZHANG Ya-jing1,WANG Ling1,WU Hong-yan2
Vol. 16, Issue 4, Pages: 4-6(2009)
摘要:Objective To observe the influence of Fuzhengzhudu Pills on immune function in mice with immunologic suppression. Method The mice were randomly divided into the blank group, model group (given cyclophosphamide and normal saline solution), high-dose Fuzhengzhudu Pills group (given cyclophosphamide and high dose of Fuzhengzhudu Pills) and low-dose Fuzhengzhudu Pills group (given cyclophosphamide and low dose of Fuzhengzhudu Pills). The model of immunologic suppression was established by hypodermic injection of cyclophosphamide (100 mg/kg) in all groups except the blank group. After 14 days CD4 cells, CD8 cells, interleukin-8 (IL-8), interleukin-2 (IL-8) and tumor necrosis factor (TNF) in mice were detected. Result Fuzhengzhudu Pills increased the percentage of CD4 cells and CD8 cells, and induced serum contents of TNF, IL-2 and IL-8 in mice with immunologic suppression. Conclusion Fuzhengzhudu Pills has a good regulation effect on the immune function in mice with immunologic suppression.
摘要:Objective To observe the effects of Feixian Formula used for anti-oxdative damage in rats with pulmonary fibrosis induced by bleomycin and compare Feixian Formula with prednisone. Method The rat model of pulmonary fibrosis was established by intratracheal injection of bleomycin (BLM). The levels of malondialdehyde (MDA) and glutathione (GSH) in lung homogenate were detected in the model group, sham-operation group, Feixian Formula group and prednisone group respectively after the model establishment for 14, 28 and 45 days. Result At the time point of 14-day, 28-day or 45-day MDA level was higher, and GSH level was lower significantly in the model group, prednisone group and Feixian Formula group than those in the sham-operation group. At the time point of 45-day MDA level decreased, and GSH level increased in Feixian Formula group than those in prednisone group. Conclusion Feixian Formula has the effect of anti-oxdative damage.
摘要:Objective To study the curative effect of the therapy of warming yang, activating blood circulation and detoxicating on HBeAg-negative chronic hepatitis B. Method The patients with HBeAg-negative chronic hepatitis B (n=85) were randomly divided into the treatment group (n=44) and the control group (n=41). The treatment group was treated with the therapy of warming yang, activating blood circulation and detoxicating, and the control group, with routine hepatic protective drugs. The levels of serum alanine aminotransferase and DNA of hepatitis B virus (HBV DNA) were observed in two groups. Result The total effective rate in the treatment group (77.27%) was significantly higher than that in the control group (48.78%) with a greatly significant difference (P< 0.01). The effectual rate in the treatment group (36.36%) was higher than that in the control group (17.07%) with a significant difference (P<0.05). After the treatment with the therapy of warming yang, activating blood circulation and detoxicating, the HBV DNA level decreased significantly than that before the treatment with a greatly significant difference (P<0.01) in the patients without HBV DNA negative corversion in the treatment group. After the treatment the HBV DNA level was significantly lower in the treatment group than that in the control group with a greatly significant difference (P<0.01). Conclusion The therapy of warming yang, activating blood circulation and detoxicating can treat effectively HBeAg-negative chronic hepatitis B through stabilizing liver function and inhibiting the reproduction of HBV DNA.
关键词:hepatitis B;HBeAg-negative;therapy of warming yang, activating blood circulation and detoxicating
摘要:Objective To investigate the intervening result of TCM health education in patients with diabetes. Method The subjective assessment (including basic knowledge on diabetes, meals according to TCM syndrome differentiation and TCM health preserving knowledge) and the changes of biochemical indexes (including fasting blood glucose, 2-hour postprandial blood sugar and glycosylated hemoglobin) were surveyed and compared before and after the education in the patients with diabetes who willingly participated the TCM health education. Result The subjective assessment and biochemical indexes had statistical significance in the patients with diabetes participated the education. Conclusion TCM health education can improve the cognition, subjective initiative, life style and biochemical indexes of the patients with diabetes, and is helpful to control diabetes and reach the aim of diabetes secondary prevention.
摘要:Objective To study the correlation between tongue characteristics and AIDS stages in the patients with HIV/AIDS. Method The patients with HIV/AIDS were observed and their tongue characteristics were recorded by applying the method of multi- stage stratified random sampling. Result The occurrence frequency of pale tongue was 5.0% in non-symptom HIV infectious stage and 8.3% in AIDS stage with a statistical significance in difference. The occurrence frequency of red tongue was the highest, 42.0% in non -symptom HIV infectious stage and 44.3% in AIDS stage without statistical significance in difference. The occurrence frequency of bulgy tongue and teeth-printed tongue was 15.6% and 9.0% respectively in non-symptom HIV infectious stage, and 23.2% and 12.8% respectively in AIDS stage with statistical significance in difference between two stages. The occurrence frequency of swelling subglossal vessels is the highest, next was thin-short subglossal vessels, next, cyanosis subglossal vessels, and next, varicose subglossal vessels, without statistical significance in difference between two stages. Conclusion The pathological evil of AIDS has the characteristics of heat-toxin, damp-turbidity, stasis-inducing, and qi-yin-blood impairment.
摘要:Objective To observe the curative effect of Naomai`an Capsules in patients with acute cerebral infarction (ACI) of syndrome type of phlegm-stasis obstructing collaterals and its influence on plasma endothelin (ET). Method The patients with diagnosed ACI of syndrome type of phlegm-stasis obstructing collaterals (n=88) were randomly divided into the treatment group and control group (each n=44). Two groups had the same basic treatment and then the treatment group was given Naomai`an Capsules orally and the control group, nimodipine and aspirin orally. The changes of European stroke scale (ESS) and ET were observed in two groups before and after the treatment. Result After treatment for 2 weeks ESS was improved and ET level was decreased significantly in the treatment group than those in the control group (P<0.001). Conclusion Naomai`an Capsules has a reliable curative effect on ACI of syndrome type of phlegm-stasis obstructing collaterals.
摘要:Objective To discuss the curative effect of Radix et Rhizoma Rhei on periodontal abscess. Method The patients with periodontal abscess (n=90) were randomly divided into Dahuang Extract Solution group, metronidazole group and iodine glycerin group. Beside clean and routine treatment 3 groups were treated with relevant drugs. The periodontal pocket depth (PD), tooth bleeding index (BI) and tooth mobility displacement (MD) were observed for reviewing the complex curative effects on the 1st and 2nd week after the treatment beginning. Result The symptoms were all relieved in three groups, and in Dahuang Extract Solution group and iodine glycerin group the difference between effective rate is significant (P<0.05). Conclusion Dahuang Extract Solution is effective and simple for curing periodontal abscess and worth spreading in clinic.
摘要:Objective To observe the curative effect of self-made Qingxinningshen Decoction on insomnia. Method The patients with insomnia (n=62) were randomly divided into the treatment group (n=42) treated with Qingxinningshen Decoction orally, one decoction a day, and the control group (n=20) treated with Tianwangbuxin Pills orally, 8 pieces once and 3 times a day. Result After 3 weeks the total effective rate was 92.86% in the treatment group and 75.00% in the control group. There was a significant difference between two groups (P<0.01). Conclusion Qingxinningshen Decoction has good curative effect for curing insomnia.
摘要:Objective To observe the curative effect of Shuxuening Injection on vertebrobasilar insufficiency dizziness. Method The patients (n=60) were randomly divided into two groups, including the treatment group (n=40) given Shuxuening Injection [20 mL added into 5% dextrose solution (250 mL, normal saline solution for patients with diabetes)] by intravenous drip, and the control group (n=20) given cinepazide [160 mg added into normal saline solution (250 mL)] by intravenous drip, once a day for 7 days. The stop time of dizziness was recorded after the treatment and the changes of blood viscosity indexes and symptoms were observed before and after the treatment. Result The total effective rate in the treatment group (92.5%) was significantly higher than that in the control group (75.0%, P<0.05). When the cases were treated for 24~72 hours and more than 72 hours the dizziness was stopped in 21 and 3 cases respectively in the treatment group, and 3 and 5 cases in the control group. The comparison between two groups was greatly significantly different and significantly different respectively (P<0.01, P<0.05). Conclusion Shuxuening Injection has a good curative effect on vertebrobasilar insufficiency dizziness.
摘要:Objective To observe the curative effect of Qiyaoxiaoke Capsules on diabetic nephropathy. Method The patients with diabetic nephropathy (n=95) were randomly divided into the treatment group (n=64) and control group (n=31). On the base of routine treatment in two groups the treatment group was given additionally Qiyaoxiaoke Capsules. After 3 months the clinical effective rate, curative effect of TCM syndrome, 24 hours urine albumin excretion rate (24h-UAER) and urine β2-microglobulin (β2-MG) were compared in two groups. Result The total effective rate was 85.9% in the treatment group and 74.2% in the control group (P<0.05). The total effective rate of TCM syndrome was 92.2% in the treatment group and 80.6% in the control group (P<0.05). In the treatment group 24h -UAER and β2 -MG decreased significantly after the treatment (P <0.01). There were 44 cases with the normalization of 24h-UAER among 64 cases in the treatment group and only 17 cases in the control group (P<0.05). Conclusion Qiyaoxiaoke Capsules can prevent and cure early diabetic nephropathy, and relieve clinical symptoms effectively.
摘要:Objective To observe the curative effect of acupoint lifting -pinching manipulation accompanied by acupuncture on ankylosing spondylitis. Method The acupoint lifting-pinching manipulation accompanied by acupuncture was used in 27 patients with ankylosing spondylitis. Result There were 18 cases cured (66.7%), 5 cases with obvious effect (18.5%), 3 cases with effect (11.1%) and 1 cases without any effect (3.7%). The total effective rate was 96.3%. Conclusion The acupoint lifting-pinching manipulation accompanied by acupuncture has a significant curative effect on ankylosing spondylitis.