最新刊期
期 6 ， 2012
- 摘要：Some common clinical research methods, used in the studies on diabetic nephropathy （DN） with Chinese medicine, were analyzed, such as randomized controlled trial （RCT）, cohort study and cultural retrieve for difficult points in case reports. In RCT, because DN patients have multiple complicating diseases with large individual difference, homogeneity is difficult to ensure, the quality of Chinese medicinal placebo makes patients break blind and have a tendency of selective treatment, and TCM holistic concept and individualization principles in clinic affect the enclosing of patients, the results of RCT will be effected, bias will be produced, and credibility of the results will be influenced. In cohort study, the ability to control bias is limited because of the complexity of syndrome differentiation and treatment in DN patients. In case report research, the intervention of other therapies can not be controlled and the influences of natural disease course and outcomes can not be removed because of comprehensive treatment for DN. So the available evidences can not be provided for proving cause-and-effect relationship. When the research on DN with Chinese medicine applies evidence-based medicine, the influence of suitability of methodology on the research results should be paid attention to.关键词：diabetic nephropathy;clinical research methods;analysis
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发布时间：2021-05-20 - 摘要：<正>糖尿病肾病即糖尿病性肾小球硬化症,由微血管病变引起,是糖尿病严重和常见的慢性并发症,也是导致终末期肾病和糖尿病患者死亡的主要原因之一。中医药自古以来就有许多类似糖尿病肾病的记载,根据其临床表现,糖尿病肾病的早、中期与中医学描述的消渴病的下消（肾消）相似,后期则属水肿、关键词：糖尿病肾病;虚气留滞;病机
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发布时间：2021-05-20 -
Retrospective analysis on modified Didang Tang for treating microalbuminuria of diabetic nephropathy
摘要：Objective To observe the curative effect of modified Didang Tang on microalbuminuria of diabetic nephropathy （DN）. Methods The method of retrospective analysis was applied to collect the eligible DN patients from the outpatients treated by Professor TONG Xiao-lin in the Department of Endocrinology of our hospital. All patients were given decoction after syndrome differentiation. The changes of urinary albumin excretion rate （UAER）, HbA1C, blood pressure and blood fat were observed before and after the treatment. The statistic method was used to process and analyze the data. Results after 3 and 6 months, UAER decreased significantly （P<0.01） and the total effective rate was, respectively, 92.1% and 90.5%. After 3 months the increase of HbA1C, systolic pressure and total cholesterol had statistical significance （P<0.05, P<0.01）. The changes of other indexes had no statistical differences. Conclusion Modified Didang Tang can ameliorate microalbuminuria and reduce HbA1C, systolic pressure and total cholesterol in DN patients.关键词：diabetic nephropathy;urinary albumin;Didang Tang- 10
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发布时间：2021-05-20 - 摘要：Objective To investigate the relationship between the circuit of year in prenatal period and morbidity of diabetic nephropathy （DN）a nd related risk factors in DN patients. Methods The information about circuit of year in their birth dates, complications and general demographic data were colleted from 436 patients with diabetes hospitalized in the Department of Nephrology of Dongzhimen Hospital. All patients were divided into DN group （n=277） and non-DN group （n=159） and given comparison. Results The risk factors of DN included hypertension, coronary heart disease （CHD）, dyslipidemia and oldness （over 60） and the difference in their constituent ratio among all complication had significance （P<0.05）. The circuit of year inducing possibly the increase of DN morbidity was the deficiency of Tu circuit. Conclusion The related risk factors of DN include hypertension, CHD, dyslipidemia and oldness （over 60）, and the deficiency of Tu circuit. The morbidity of DN is correlated to the circuit of year in prenatal period.关键词：diabetic nephropathy;circuit of year;correlation;risk factors
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of moxa-smoke condensate on morphology and cytoactive of type Ⅱ pneumonocytes A549. Methods A546 cells were cultured in vitro and then moxa-smoke condensate in different concentration was added in the cells. The influences of moxa-smoke condensate on the morphology and cytoactive of A546 cells were observed by applying fluorescence microscope and MTT assay after 24 hours. Results The observation of fluorescence microscope showed that when the concentration of moxa-smoke condensate was in 0.05 g/L, the morphology of A546 cells had no changes basically, and when the concentration was higher than 0.05 g/L, the morphology changed gradually and the number decreased gradually showing a concentration-dependence. The results of MTT assay showed that, compared with control group, the cytoactive of A546 cells had no statistical difference when the concentration of moxa-smoke condensate was in 0.09 g/L （P=0.985）, and had significant difference when the concentration was in 0.06 g/L and 0.12 mg/mL respectively （P=0.036, P=0.013）. When the concentration was higher than 0.12 g/L, there was great significance （all P<0.01）, and cytoactive of A546 cells had a gradual decreasing tendency showing a concentration-dependence. Conclusion Within 24-hour stimulating period, low-concentration moxa-smoke condensate may have no effect on A546 cells, and high-concentration of it has some toxic effect showing a significant concentration-dependence.关键词：moxa-smoke condensate;type Ⅱ pneumonocytes;cell morphology;cytoactive
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of Kangxian Yifei Capsules on lung histopathological changes and serum tumor necrosis factor-α （TNF-α） and transforming growth factor-β1 （TGF-β1） in rats with pulmonary fibrosis induced by bleomycin. Methods Health Wistar rats （n=60） were randomly divided into normal group, model group, positive control group, and high-dose, mid-dose and low-dose Kangxian Yifei Capsules groups （high-dose group, mid-dose group and low-dose group）. The rat model of pulmonary fibrosis was established by tracheal instillation of bleomycin solution, and after 48 hours all groups were respectively given normal saline solution, prednisone suspension, and high-dose, mid-dose and low-dose Kangxian Yifei Capsules once a day for 28 days. The histomorphological changes of lung, lung coefficient, hydroxyproline （HYP） in lung tissue and serum TNF-α and TGF-β1 were observed and detected. Results Compared with model group, the histomorphological changes of lung were relieved significantly in all groups of Kangxian Yifei Capsules and positive control group. Along with the increase of dose of Kangxian Yifei Capsules, the degree of pulmonary fibrosis decreased. HYP, TNF-α and TGF-β1 were significantly lower in all groups of Kangxian Yifei Capsules than those in model group （P<0.05）, which was more significant as the increases of dose. Compared with positive control group, HYP decreased significantly in high-dose group （P<0.05）. Conclusion The inhibition of the expressions of TNF-α and TGF-β1 and collagen synthesis may be one of anti-fibrosis mechanisms of Kangxian Yifei Capsules.关键词：Kangxian Yifei Capsules;pulmonary fibrosis;rats;tumor necrosis factor-α;transforming growth factor-β1
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of electroacupuncture in different acupoints on tumor necrosis factor-α （TNF-α） and glutathione （GSH） distributed in different viscera in rats with chronic obstructive pulmonary disease （COPD）. Methods Wistar male rats （n=28） were divided into normal group, model group, Chize （LU5） group and Fenglong （ST40） group （each n=7）. Except normal group, other groups were given tracheal instillation of LPS combining smoking method for establishing COPD model, and at the same time were given electroacupuncture once every other day for 12 times. When the test was finished, the samples were taken and homogenized, and the content of TNF-α in lung and intestines and the content of GSH in liver, spleen, lung and intestines were detected by using radioimmunoassay. Results The content of TNF-α in lung was higher than that in intestines in all groups, and increased significantly in normal group and ST40 group （P<0.05）. Compared with normal group, the content of GSH in spleen increased significantly （P<0.05） and decreased significantly in intestines （P<0.05） in model group, and decreased significantly in ST40 group （P<0.05）. Compared with model group, the content of GSH in spleen decreased significantly in LU5 group （P<0.05）, decreased significantly in lung in ST40 group （P<0.05）. The content of GSH in intestines and spleen was higher than that in lung and liver in normal group （P<0.01, P<0.05）, and was higher in intestines than that in spleen （P<0.05）. The content of GSH in spleen was higher than that in liver in model group （P<0.01）, and was higher in intestines than that in lung and liver in LU5 group （P<0.05）. The content of GSH in spleen and intestines was higher significantly than that in lung and liver in ST40 group （P<0.01）. Conclusion Electroacupuncture in LU5 and ST40 can reduce the content of GSH in liver, spleen and lung, which is more significant in spleen during electroacupuncture in LU5 and more significant in lung during electroacupuncture in ST40. The pathological stimulation of COPD can induce the rank swap of the content of GSH in spleen and intestines. Electroacupuncture in LU5 can recover this rank change, and electroacupuncture in ST40 can not correct this rank chang.关键词：chronic obstructive pulmonary disease;Chize （LU5）;Fenglong （ST40）;tumor necrosis factor-α;glutathione;rats
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发布时间：2021-05-20 - 摘要：Objective To investigate the best opportunity of electroacupuncture intervention and the meaning of urodynamics examination in patients with urinary retention after cervix cancer surgery. Methods The patients with urinary retention after cervix cancer surgery （n=58） were observed and divided into control group （without electroacupuncture, n=19）, treatment group 1 （with electroacupuncture 8 days after surgery, n=19） and treatment group 2 （with electroacupuncture 15 days after surgery, n=20）. A therapeutic course included 6 times of electroacupuncture once a day. The examinations of residual urine volume （RUV） and urodynamics were given to the patients respectively after the treatment and the patients were followed up. Results The reduction of RUV （ΔPVR） was, respectively in three groups, （127.68±134.45） mL, （367.58±227.58） mL and （235.20±170.25） mL （P<0.05）. The total effective rate was, respectively in three groups, 15.79%, 63.16% and 45.00%. There was no statistical significance in the difference between treatment group 1 and control group and between treatment group 2 and control group. The average bearing time of urinary canal was, respectively in three groups, （42.11±24.88） days, （23.26±14.07） days and （30.80±12.65） days （P<0.05）. The average flow rate, bladder capacity and detrusor pressure decreased in the patients before electroacupuncture and improve after the treatment. Conclusion The early intervention with electroacupuncture is good to recovering of bladder function, and the best opportunity is within 7 days after the surgery. The examination of urodynamics can help to judge the lesion degree of bladder after the surgery, predict curative effect and guide clinical practice.关键词：cervix cancer;urinary retention;residual urine;urodynamics
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发布时间：2021-05-20 - 摘要：Objective To probe into the correlation between blood gas analysis and syndromes in the patients with chest stuffiness. Methods The patients （n=60） with the symptoms of chest oppression were divided into qi deficiency group, yang deficiency group and yin deficiency group, and then the distribution laws of blood gas analysis results were analyzed in all groups. Results The results showed that pH value increased gradually from yin deficiency to yang deficiency to qi deficiency, PaO2 increased gradually from yang deficiency to qi deficiency to yin deficiency, and PaCO2 increased gradually from qi deficiency to yin deficiency to yang deficiency with significant difference. Conclusion The blood gas analysis can be used as objective evidence for the clinical syndrome differentiation of chest stuffiness.关键词：chest stuffiness;chest oppression;blood gas analysis
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发布时间：2021-05-20 - 摘要：<正>特发性肺纤维化（idiopathic pulmonary fibrosis,IPF）是间质性肺疾病中最具有代表性的病种,其病因不清,尤其是目前在治疗上尚无有效的方法,它一直是呼吸系统疾病诊治的难点和研究热点。近年来,中医药诊治IPF报告数量逐渐增加,虽然使用的疗效评价指标众多,但可信度较低。本文将简述当前中医药诊治IPF研究中所使用的疗效评价指标,关键词：疗效指标;特发性肺纤维化;中医药
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发布时间：2021-05-20 - 摘要：<正>严格评价（critical appraisal）是临床医生和医学生应当具备的一项基本技能,是循证医学和循证临床实践的重要组成部分。它是对发表的临床科研论文从真实性和实用性两方面进行批评性评价,找出被评价研究的优缺点,以便临床医生应用证据时合理判断和使用。本文将选择既往发表的中医药临床试验文章进行严格评价,通过规范的信息提取和评关键词：严格评价;随机对照试验;中医药;方法学
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发布时间：2021-05-20 - 摘要：Objective To investigate the intervening effect of application on acupoint with Chinese medicinals on hyperplasia of mammary glands （type of liver qi depression）. Methods The objects （n=50） diagnosed as hyperplasia of mammary glands （type of liver qi depression） were divided, according to random digits method, into two groups. The experiment group （n=25） was given acupoint application with Chinese medicinals [Chaihu （Radix Bupleuri）, Shaoyao （Peony）, Zhishi （Fructus Aurantii Immaturus）, Gancao （Radix Glycyrrhizae） and Aiye （Folium Artemisiae Argyi）] on Rugen （ST18）, Qimen （LR14） and Ashi points, and control group （n=25） was given acupoint application with （Chaihu powder and edible caramel color） on the same acupoints. After three months, breast pain, the size of hyperplasic lumps, and breast B-type ultrasonic examination were observed and compared between two groups. Results The pain scores and size of hyperplasic lumps were ameliorated significantly in experiment group compared with those before intervention （P<0.05, P<0.01）.The total effective rate was 68% in overall curative effect. Conclusion The application on acupoint with Chinese medicinals can relieve breast pain and reduce the size of hyperplasic lumps in the patients with hyperplasia of mammary glands （type of liver qi depression）.关键词：hyperplasia of mammary glands;liver qi depression;application on acupoint;Sini San
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发布时间：2021-05-20 - 摘要：Objective To observe the curative effect of external therapy of TCM on postsurgical gastroparesis syndrome （PGS） in cancer patients. Methods The external therapy of TCM was used in 65 cases for treating PGS. Moxa sticks were ignited and cauterized on the acupoints of Shangwan （CV13）, Zhongwan （CV12） and Shenque （CV8） for 5 minutes, and after the local skin warmed, the external medicinals were applied on these acupoints, on which the moxibustion was given again for 15 minutes. The Chinese medicinals for external application included Muxiang （Radix Aucklandiae）, Xiangfu （Rhizoma Cyperi）, Zhiqiao （Fructus Aurantii）, Houpo （Cortex Magnoliae Officinalis）, Jiang Banxia （Rhizoma Pinelliae prepared with ginger）, Dingxiang （Flos Caryophylli）, Ganjiang （Rhizoma Zingiberis）, Rougui （Cortex Cinnamomi）, Chuanshanjia （Squama Manitis）, Quanxie （Scorpio） and Yanhusuo （Rhizoma Corydalis）. The external application was continued for 2 hours to 3 hours and then taken off （once or two times a day）. The observation period was 30 days. Results There were 59 cases cured （90.77%）, 4 relived （6.15%）, and 2 without curative effect （3.08%）. The total effective rate was 96.92%. The shortest time of recovering eating （no obvious discomfort） was 6 days and the longest time was 30 days after pulling out nasogastric tube. All patients did not have skin allergic phenomenon. Conclusion The external therapy of TCM had direct action with better curative effect, which is easy in operation and good for treating PGS.关键词：postsurgical gastroparesis syndrome;external therapy of TCM;external application with Chinese medicinals;moxa-moxibustion
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发布时间：2021-05-20 - 摘要：Objective To observe the curative effect of Mankuining Enema on ulcerative colitis. Methods The patients （n=60） were selected from outpatient and inpatient departments from Feb. 2011 to Feb. 2012, and then randomly divided into treatment group and control group. The treatment group （n=30） was given Mankuining Enema and control group （n=30）, Sulfasalazine Suppositories. The two groups were all given modified Baitouweng Tang orally. A therapeutic course was 2 months. Results Compared with control group, the symptoms including diarrhea, bloody purulent stool and tenesmus were significantly relieved in treatment group （P<0.05）. The curative effects on intestinal mucosal hyperemia, edema and erosion were better in treatment group than those in control group （P<0.05）. The total effective rate was 90.0% in treatment group and 76.7% in control group （P<0.05）. In the aspect of improving the indexes of erythrocyte sedimentation rate （ESR）, treatment group was better than control group （P<0.05）. Conclusion Mankuining Enema can improve the curative effect and it is a effective formula for assistant treatment of ulcerative colitis.关键词：Mankuining Enema;ulcerative colitis;clinical study
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发布时间：2021-05-20 - 摘要：Astronauts will have multiple adverse physiological and pathological reactions in weightlessness condition, and muscle atrophy is one of the most obvious changes manifesting as the reduction of muscle volume and weight, inability of limb lifting and so on. There are no the descriptions about corresponding disease in traditional TCM classics. According to the symptoms of muscle atrophy in weightlessness condition, we classify it into the category of fleshy wilting in wilting syndrome. Under the guide of holistic concept and syndrome differentiation and treatment and referring to the cognition on fleshy wilting by doctors in the past dynasties, we think that the main pathogenesis of muscle atrophy induced by weightlessness are spleen qi deficiency and lack of nutrition of muscle in early stage, and deficiency of spleen and kidney, and qi deficiency and blood stasis in later stage.关键词：weightlessness;muscle atrophy;TCM pathogenesis
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发布时间：2021-05-20 - 摘要：<正>清代名医叶桂,字香岩,号天士,他创立的卫气营血辨证体系成为温病学形成的坚实基础,被后世尊称为温热大师。叶氏也精于内科、幼科、妇科、外科、老年科等。《清史稿》中说:"大江南北,言医者,辄以桂为宗,百余年来,私淑者众。"叶氏平生忙于诊务,著作不多。由其门人、后人整理而成的《温热论》《临证指南医案》最具代表性,反映了叶氏的学术思关键词：叶天士;老年病;防治;学术思想
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发布时间：2021-05-20 - 摘要：<正>"六对论治"是吕仁和教授在长期医疗实践中总结形成的经验思维模式,即:对症论治、对症辨证论治、对症辨病与辨证相结合论治、对病论治、对病辨证论治、对病分期辨证论治[1],该经验已经成功用于痛风肾病、糖尿病、糖尿病周围神经病变等多种疾病的治疗,都取得了较好的临床效果[2-3]。我们在跟随关键词：内伤发热;六对论治;肾移植
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发布时间：2021-05-20 - 摘要：<正>鲁承业老师是北京中医药大学附属护国寺中医医院主任医师。19岁从师于施今墨先生的叔叔施少航先生,后又从师于脾胃病专家鲍友麟先生,1972年得脾胃病专家步玉如先生亲传。博采众家,撷取精华,融会贯通,为我所用。从医40余年,逐渐形成了自己的独特诊疗思想体系。遵循古方,但不拘泥;强调人体的整体观;注重对亚健康的调治,强调调治关键词：阴虚;萎缩性胃炎;酸甘化阴
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发布时间：2021-05-20 - 摘要：<正>1病例介绍患者苏某,男,80岁,主因"胸闷胸痛间断发作40余年,加重伴发热、咳嗽、喘憋3d"于2012年3月30日以"冠状动脉粥样硬化性心脏病"收入院。患者40余年前于劳累时出现胸前区疼痛,伴胸闷、乏力,休息或服用硝酸甘油后约35min后可缓解。10年前诊断为"急性心肌梗死",行"右冠状动脉植入支架术"（具体不详）,后患者规律服用冠心病二级关键词：益气活血法;冠心病;心衰
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发布时间：2021-05-20 - 摘要：<正>1首辨血热血瘀,施凉血化瘀之法中医学早就有"久病多瘀"之说。清代名医叶天士明确指出:"初气结在经,久则血伤入络。"由于本病是慢性疾患,久病入络,故临床多见有不同程度的血瘀征象,如局部刺痛或胀满,扪及结块,口渴但漱水而不欲饮,肌肤甲错,舌质青紫或有瘀点、瘀斑,等等。瘀血发黄的主要特点是小便自利。《普济方》中关键词：高黄疸;辨治;慢性重型肝炎
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发布时间：2021-05-20
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