最新刊期
期 1 ， 2013
- 摘要：The therapy of resolving phlegm and relaxing bowels now has been a major therapy for treating syndrome of phlegm heat and bowel excess of stroke in the fields of Chinese medicine and integrated Western and Chinese medicine. The authors reviewed the history and origin of the therapy, and introduced the discovery process of the syndrome from the visual angle of spring up. The authors observed bowel qi obstruction at the beginning of stroke, pondered over the simultaneous emergence of bowel qi obstruction and phlegm heat syndrome and relationship between the syndrome and disease severity, and analyzed the occurrence of syndrome of phlegm heat and bowel excess, accumulation of brain collateral damaged by internal toxin, and multiple ways of concurrence of the syndrome. Furthermore, the key points of syndrome differentiation, identification of syndromes, formula design and medication, modification, decocting methods, detailed rules, and application range of formulas according to clinical condition, observation indications, prognosis and contraindications of the syndrome, and clinical application of therapy of resolving phlegm and relaxing bowels were stated systematically in the paper.关键词：therapy of resolving phlegm and relaxing bowels;stroke;syndrome of phlegm heat and bowel excess
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发布时间：2021-05-20 - 摘要：<正>中国期刊全文数据库（中国学术期刊（光盘版）编辑委员会、中国学术期刊（光盘版）电子杂志社）中国学术期刊综合评价数据库（中国学术期刊（光盘版）编辑委员会、中国科学文献计量评价研究中心）中国核心期刊（遴选）数据库（中国科学技术信息研究所、万方数据股份有限公司）
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发布时间：2021-05-20 - 摘要：Gastric cancer is one of the most common malignant tumors in China and has the highest incidence and mortality, which is a serious threat to people’s health and life safety. Precancerous lesions of gastric cancer（PLGC） are kind of pathological changes being easily transformed into cancer. The paper expounded the cognition of TCM on PLGC from the angles of etiology, pathogenesis, classification, views of different schools, disease differentiation and treatment. The authors thought that PLGC are the syndrome of deficiency in the root and excess in the tip. The deficiency in the root shows as spleen-stomach qi deficiency and/or spleen-stomach yin deficiency, and excess in the tip shows as blood stasis in stomach collateral and toxin damaging stomach collateral. The syndrome differentiation and treatment divides PLGC into three to five types. Different TCM physicians have various opinions and select various medicinals for treating the disease according its specific pathological changes. The problems existing in the research on PLGC were analyzed and future studies were prospected in the paper.关键词：gastric precancerous lesions of gastric canaer;Chinese medicine;review
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发布时间：2021-05-20 - 摘要：Objective To observe the influence of therapy of tonifying qi, resolving stasis and removing toxicity on c-myc gene in rats with chronic atrophic gastritis complicating dysplasia. Methods Wistar rats （n=60） were randomly divided into modeling group （n=50） and blank group （n=10）. After successful modeling the rest of rats （n=30） were randomly divided into model group, Weimeisu group and Chinese medicinal group （each n=10）. The model group was give normal saline water, Weimeisu group was given Weimeisu turbid liquid and Chinese medicinal group was given the Chinese medicinals with actions of tonifying qi, resolving stasis and removing toxicity （once a day）. After continuous treatment for 12 weeks, the methods of real-time fluorescence quantitative polymerase chain reaction （RT-PCR） and Western blot were used for detecting c-myc gene in rats of all groups. Results The expression of c-myc mRNA increased significantly in model group compared with blank group （P<0.01）, decreased significantly in Chinese medicinal group compared with model group （P<0.01）, and decreased in Chinese medicinal group compared with Weimeisu group （P<0.05）, and increased in Weimeisu group compared with blank group （P<0.05）. The difference in the comparison between Chinese medicinal group and blank group had no statistical significance （P>0.05）, and that between Weimeisu group and model group had no statistical significance （P>0.05）. The expression of c-myc protein was significantly higher in model group than that in blank group （P<0.01）, lower significantly in Chinese medicinal group than that in model group （P<0.01）, lower in Weimeisu group than that in model group （P<0.05） and higher in Weimeisu group than that in blank group （P<0.05）. The difference in the comparison between Chinese medicinal group and blank group had no statistical significance （P>0.05）, and that between Chinese medicinal group and Weimeisu group had no statistical significance （P>0.05）. Conclusion The therapy of tonifying qi, resolving stasis and removing toxicity can reverse gastric mucosal dysplasia through inhibiting the expressions of c-myc mRNA and c-myc protein.关键词：chronic atrophic gastritis complicating dysplasia;therapy of tonifying qi, resolving stasis and removing toxicity;c-myc;rats
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发布时间：2021-05-20 - 摘要：Objective To investigate the theory basis of treating precancerous lesions of gastric cancer（PLGC） of chronic atrophic gastritis （CAG） from theory of qi deficiency and blood stasis through literature sorting out and summing up, and observe the curative effect the therapy of supplementing qi and activating blood on PLGC of CAG （syndrome of qi deficiency and blood stasis）. Methods The theory basis of treating PLGC of CAG from theory of qi deficiency and blood stasis was summed up through literature sorting out. The patients （n=60） were randomly divided into treatment group and control group （each n=30）. Treatment group was given Yiqi Huoxue Fang orally, and control group was given Weifuchun Pian orally. The therapeutic course was 6 months. The integrals of TCM symptoms, curative effect and integrals of pathological indexes were observed. Results The theory basis of treating PLGC of CAG from theory of qi deficiency and blood stasis was sufficient. The integrals of stomach duct pain and gastric stuffiness decreased in two groups after treatment （P<0.01）. The integrals of loss of appetite, lack of strength, gastric upset, ructus and sloppy stool decreased in treatment group after treatment （P<0.01）. The difference in the integrals of TCM symptoms had statistical significance between two groups after treatment （P<0.05）, and the curative effect on TCM syndromes was better in treatment group than that in control group （P<0.01）. The integrals of gastic atrophy and intestinal metaplasia decreased in two groups after treatment （P<0.01）. The difference in integrals of gastic atrophy had statistical significance between two groups after treatment （P<0.05） and the curative effect was better in treatment group than that in control group. Conclusion The treatment of PLGC of CAG from theory of qi deficiency and blood stasis has sufficient theory basis, and the therapy of supplementing qi and activating blood has good curative effect on PLGC of CAG .关键词：qi deficiency and blood stasis;chronic atrophic gastritis;precancerous lesions of gastric cancer;supplementing qi and activating blood
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发布时间：2021-05-20 - 摘要：Objective To observe the influence of Chinese medicinals with actions of fortifying the spleen, clearing heat, activating blood and resolving stasis on gastric mucosal histological changes in rat model of chronic atrophic gastritis （CAG） accompanied by atypical hyperplasia for discussing the effective mechanism of Chinese medicinals. Methods All 70 rats were randomly divided into normal group, model group, modeling blank group, prevention group with Chinese medicinals （CMP group）, prevention group with Western medicinals （WMP group）, treatment group with Chinese medicinals （CMT group） and treatment group with Western medicinals （WMT group）. The animal model of chronic atrophic gastritis accompanied by atypical hyperplasia was copied by using chemical stimulus method, and changes of gastric mucosal mitochondrial membrane potential （MMP） were detected by using flow cytometer. Results MMP increased in model group compared with normal group （P<0.05）, decreased in CMP group and WMP group compared with model group （P<0.05）. MMP increased in CMP group and WMP group compared with normal group （P<0.05）. MMP decreased in CMP group compared with WMP group （P<0.05）. The curative effect was higher in CMP group than that in WMP group. MMP increased in modeling blank group compared with normal group （P<0.05）, and decreased in CMT group and WMT group compared with modeling blank group （P<0.05）. MMP increased in WMT group compared with normal group （P<0.05）. There was no statistical significance between CMT group and normal group （P>0.05）. MMP decreased in CMT group compared with WMT group （P<0.05）. The curative effect was higher in CMT group than that in WMT group. Conclusion The Chinese medicinals with actions of fortifying the spleen, clearing heat, activating blood and resolving stasis can treat CAG accompanied by atypical hyperplasia through reducing gastric mucosal MMP.关键词：chronic atrophic gastritis;precancerous lesions of gastric cancer;fortifying the spleen, clearing heat, activating blood and resolving stasis;mitochondrial membrane potential;rats
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发布时间：2021-05-20 - 摘要：Objective To analyze and sum up Professor TANG Xu-dong’s medication experience on chronic atrophic gastritis （CAG） by applying data mining. Methods The materials were collected from 113 patients with CAG （148 visit times） treated by Professor TANG Xu-dong. The extract and input of materials and data structuring were carried out, and information collection module was built by applying the system of diagnostic and treatment information collection from famous and senior TCM physicians. The frequency analysis was used for analyzing and summing up the medication laws of common formulas and medicinals for different syndrome types. The data mining software was used for analyzing association rules of the corresponding combination relations between symptoms and medicinals and between medicinals and medicinals, and summarizing the laws in medicinal modification and combination. Results The main syndrome types of CAG included syndrome of liver depression and qi stagnation, syndrome of dampness-heat in spleen and stomach, spleen-stomach weakness syndrome, syndrome of depression-heat in liver and stomach and syndrome of stomach yin deficiency. The syndrome of liver depression and qi stagnation was treated with Xiangsu Yin, Sini San and modified Dan shan Yin, syndrome of dampness-heat in spleen and stomach, with Huangqin Huashi Tang, Banxia Xiexin Tang or modified Huanglian Wendan Tang, spleen-stomach weakness syndrome, with Huangqi （Radix Astragali seu Hedysari） combining modified Xiangsha Liujunzi Tang, syndrome of depression-heat in liver and stomach, with Xiangsu Yin combining Jinlingzi San and modified Zuojin Wan, and syndrome of stomach yin deficiency, with Yiwei Tang or Yiguan Jian. In the aspect of medicinal combination, common ones for regulating qi included the combinations among Xiangsu Yin, Zisuzi （Fructus Perillae）, Chaihu （Radix Bupleuri）, Zhiqiao （Fructus Aurantii）, Sharen （Fructus Amomi Villosi） and Banxia （Rhizoma Pinelliae）, and main combinations included Zisugeng （Caulis Perillae）+Chenpi （Pericarpium Citri Reticulatae）+Xiangfu （Rhizoma Cyperi）, Chaihu+Zhiqiao and Zisuzi+Zisugeng. The common medicinal combinations for activating blood and regulating qi included Chuanlianzi （Fructus Meliae Toosendan）+Yanhusuo （Rhizoma Corydalis）, Zisuzi+Xiangfu, Danshen （Radix Salviae Miltiorrhizae）+Sharen and crude Puhuang （Pollen Typhae）+fried Wulingzhi （Faeces Trogopterorum）. The common medicinal combinations for clearing heat and resolving dampness included the combinations among Huanglian （Rhizoma Coptidis）, alum processed Banxia, Huangqin （Radix Scutellariae）, Huashi （Talcum）, Roudoukou （Semen Myristicae）, Fuling （Poria,）, fried Baizhu （Rhizoma Atractylodis Macrocephalae） and Chenpi, and main combinations included Huashi+Huangqin+alum processed Banxia, Fuling+alum processed Banxia, fried Baizhu+alum processed Banxia, Roudoukou+alum processed Banxia and Roudoukou+Huashi. The common medicinal combinations for fortifying spleen and replenishing qi included the combinations among Dangshen （Radix Codonopsis）, fried Baizhu and Fuling. The common medicinal combinations for clearing liver and purging heat included the combination of Zuojin Wan, and among Longdancao （Radix Gentianae） and Wuzeigu （Os Sepiella seu Sepiae）. Conclusion Professor TANG Xu-dong’s medication experience on CAG is objectively summed up through applying data mining, which will provide the data support for deep study and comprehension of Professor TANG Xu-dong’s academic thought.关键词：chronic atrophic gastritis;medication laws;expert’s experience;data mining;association rule
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发布时间：2021-05-20 - 摘要：<正>根据国家标准GB3358-82《统计学名词及符号》的有关规定,请作者书写统计学符号时注意以下规格:①样本的算术平均数用英文斜体小写x表示,不用正体X,也不用M或Mean（中位数仍用M）;②标准差用英文斜体小写s,不用SD;③标准误用英文斜体小写sx,不用SE,也不用SEM;④t检验用英文斜体小写t;⑤F检
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发布时间：2021-05-20 - 摘要：Objective To analyze the types of TCM syndromes and clinical indexes in patients with aristolochic acid nephropathy （AAN） and provide the evidence for the standardization of AAN diagnosis. Methods The types of TCM syndromes were observed and clinical indexes were compared in AAN patients （n=33） selected as study objects. Results Involving deficiency of healthy qi and among 33 cases, there were 27 with syndrome of spleen-kidney yang deficiency （81.82%）, and 6 without syndrome of spleen-kidney yang deficiency （18.18%）. Involving excess of pathogenic qi and among 33 cases, there were 18 with dampness turbidity syndrome （54.55%）, and 15 without dampness turbidity syndrome （45.45%）. The level of 24-hour urine protein was higher in group of spleen-kidney yang deficiency than that in group of non-spleen-kidney yang deficiency （P<0.05）, and there was no statistical significance in other clinical indexes between two groups （P>0.05）. The level of serum total cholesterol （TC） and urine specific gravity were higher in dampness turbidity group than those in non-dampness turbidity group （P<0.05）, and there was no statistical significance in other clinical indexes between two groups （P>0.05）. Conclusion The TCM syndromes are showed as mixture of deficiency and excess in AAN patients with spleen-kidney yang deficiency as the root, and dampness turbidity and blood stasis as the tip. There is a correlation between clinical indexes and syndrome types.关键词：aristolochic acid nephropathy;TCM syndromes;clinical indexes
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发布时间：2021-05-20 - 摘要：<正>为了实现期刊编辑、出版工作的网络化,我刊现已入网"万方数据——数字化期刊群",向本刊投稿并录用的稿件文章,将一律由编辑部统一纳入"万方数据——数字化期刊群",进入因特网提供信息服务。凡有不同意者,请另投他刊。本刊所付稿酬包含刊物内容上网服务报酬,不再另付。"万方数据——数字化期刊群"是国家"九五"重点科技攻关项目。本刊全文内容按照统一格式制作,读者可上网查询浏览
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发布时间：2021-05-20 - 摘要：Objective To observe the curative effect of therapy of clearing lung and resolving phlegm on idiopathic pulmonary （interstitial） fibrosis （IIP, type of phlegm-heat obstructing lung） complicating infection. Methods The patients （n=81） with IIP were divided into control group （n=27） and treatment group （n=54）. Control group was treated with intravenous drip of moxifloxacin, Mucosolvin and oral Acetylcysteine Capsules, and treatment group was given the decoction of Chinese medicinal with actions of clearing lung and resolving phlegm besides the same Western medicinal as control group. The curative effect on TCM syndromes, changes of symptom integrals, 6-minute walk distance test （6MWD）, PO2 changes in blood gas analysis, and total lung capacity （TLC）, breathing capacity （VC） and DLCO in lung function were compared between two groups. Results In treatment group, there were 10 cases （18.5%） with obvious effects, 35 （64.8%） with effects, 9 （16.7%） without effects, and the total effective rate was 83.3%. In control group, there were 3 cases （11.1%）, 14 with （51.9%） effects, 10 （37.0%） without effects, and the total effective rate was 63.0%. U=-2.197, P=0.037 and P<0.05 after Ridit analysis. The scores of cough, plasma, fever, chest distress and pain, dry stool, upset, shortness of breath, yellow phlegm and moist rales were all decreased in two groups than those before treatment （P<0.05）, which were more significant in treatment group （P<0.05）. 6MWD was increased in two groups than that before treatment （P<0.01）, which was more significant in treatment group （P<0.001）. In blood gas analysis, PO2 increased in two groups than that before treatment （P<0.01）, which was more significant in treatment group （P<0.01）. In lung function DLCO increased in two groups than that before treatment （P<0.01）, which was more significant in treatment group （P<0.001）. Conclusion The therapy of clearing lung and resolving phlegm has a good curative effect on IIP （type of phlegm-heat obstructing lung）.关键词：idiopathic pulmonary （interstitial） fibrosis complicating infection;phlegm-heat obstructing lung;therapy of clearing lung and resolving phlegm
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发布时间：2021-05-20 - 摘要：Objective To discuss the curative effect of Yandi Chuxue Fang combining iontophoresis of Chinese medicinals on diabetic retinopathy. Methods The patients with diabetic retinopathy （n=80） were randomly divided into treatment group and control group （each n=40）, and all treated with Yandi Chuxue Fang. The treatment group was given iontophoresis of Chinese medicinals besides of Yandi Chuxue Fang. The curative effect was observed in two groups. Results Of 40 cases in treatment group, there were 13 with obvious effect （32.5%）, 20 with effect （50.0%）, 7 without effect （17.5%） and 0 worsened, and the total effective rate was 82.5%. Of 40 cases in control group, there were 7 with obvious effect （17.5%）, 18 with effect （45.0%）, 15 without effect （37.5%） and 0 worsened, and the effective rate was 62.5%. The comparison in the curative effect between two groups showed as follows: Z=-2.152, P=0.031 and P<0.05 after rank-sum test. Conclusion Yandi Chuxue Fang combining iontophoresis of Chinese medicinals has better curative effect than simply oral Chinese medicinals on diabetic retinopathy.关键词：diabetic retinopathy;Yandi Chuxue Fang;iontophoresis of Chinese medicinals
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发布时间：2021-05-20 - 摘要：Objective To observe the curative effects of incision therapy and comprehensive treatment on chronic throat impediment of type of phlegm coagulation and blood stasis. Methods The patients （n=100） were randomly divided into incision group （n=50） treated with incision therapy, and comprehensive group （n=50） treated with aerosol inhalation of Chinese medicinals, acupoint application and multifunction microwave irradiation. The curative effects were compared between two groups. Results There were 4 cases cured （8%）, 24 with obvious effect （48%）, 19 with effect （38%） and 3 without effect （6%）, and the total effective rate was 94% in incision group. There were 5 cases cured （10%）, 28 with obvious effect （56%）, 15 with effect （30%） and 2 without effect （4%）, and the total effective rate was 96%. The difference in the comparison of curative effect had statistical significance between two groups （P<0.05） and comprehensive group had better curative effect than incision group. Conclusion Incision therapy is easy, safe and effective on chronic throat impediment, and it will have better curative effect when combining with other proper external therapies of Chinese medicine.关键词：throat impediment;incision therapy;external therapies of Chinese medicine
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发布时间：2021-05-20 - 摘要：<正>1文内引用参考文献的标注和著录原则与方法参考文献应限于作者直接阅读过的、最主要的、最新发表在正式出版物上的文献。未公开发表的内部文件和资料、二次文献不宜作参考文献引用。按照《顺序编码制》参考文献著录格式的要求,文内参考文献标注按引用文献出现的先后顺序连续编码,并将序号置于方括号中,并视具体情况把序号连同方括号作为上角标或按正文文字排列;同一处引用多篇文献时,只需
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发布时间：2021-05-20 - 摘要：<正>对临床证据的严格评价（critical appraisal）是一项循证医学的基本技能。本文选择既往发表的中医药临床试验文章进行严格评价,旨在通过规范的信息提取和评判,指出文章中存在的方法学问题,提出改进的意见,便于临床医生和医学生学习参考。1文献来源多中心随机对照评价中医药治疗小儿病毒性肺炎风热闭肺证\痰热闭肺证临床疗效.北京中医药大学学报,2008,31（9）:629-633,642。2研究概括2.1目的评价清开灵注射液和儿童清肺口服液/小儿咳喘灵口服液联合应用治疗小儿病毒性肺炎风热闭肺证和痰热闭肺证的临床疗效。关键词：严格评价;随机对照试验;中医药;方法学
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发布时间：2021-05-20 - 摘要：<正>为了及时有效地宣传我国优秀科技论文,使我国科技期刊便于检索和查阅,为广大科研人员创造良好的文献查阅条件,教育部科技发展中心在"中国科技论文在线"网站设立"科技期刊"栏目。该栏目把选定的科技期刊所发表的论文按国家标准学科代码分类建库,同时保留原期刊特色和期刊分类。《北京中医药大学学报（中医临床版）》已被"中国科技论文在线"收录。向本刊投稿并录用的稿件文章,将一律由编辑部统一纳入"中国科技论文在线"。凡有不同意者,请另投它刊。本刊所付稿酬包含刊物内容上网服务报酬,不再另付。
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发布时间：2021-05-20 - 摘要：The cultivation of clinical thinking ability is a key point for Chinese medical students, however, the weakness of clinical thinking ability has become a prominent problem even in the postgraduates. There are quite a lot problems appeared in the case report writing by postgraduate, while reinforcing the training in case history writing is an important method to improve this ability. The training might take commonly-seen diseases as breakthrough points, and is divided into 3 stages. Stage one includes writing case history independently and finding out the problems, and emphasis is put on the content of history, using standardized terms and language logic. Stage two includes forming a frame after repeated discussion, and selecting commonly-seen diseases accorded with acupuncture-moxibustion features, such as facial paralysis and headache for compiling a framework for case history writing. Stage three includes intensifying the training by application of the frame. The frame may guide the students to think of clinical problems step by step, correct the missing and mistakes in four examinations, prompt the key points in diagnosis and treatment, therapeutic principles as well as acupoint selection, and finally form the complete understanding to diagnosis and treatment of a disease. Both teachers and students in acupuncture specialty should be fully convinced of the importance of writing training of case history for improving clinical thinking ability.关键词：degree of acupuncture-moxibustion specialty;postgraduates;writing of case history;clinical thinking ability
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发布时间：2021-05-20 - 摘要：<正>幽门螺杆菌（Helicobacter pylori,Hp）是一种专门寄生于人体胃黏膜的革兰氏阴性微需氧菌。自1983年Warren和Marshall从慢性胃炎患者的胃黏膜中分离并培养出Hp以来,人们逐渐发现Hp的感染与慢性胃炎、消化性溃疡、胃黏膜相关淋巴组织（mucosa-associated lymphoid tissue,MALT）淋巴瘤、胃癌等疾病的发生发展密切相关[1]。目前,西医临床上常用的根除Hp的一线治疗方案包括质子泵抑制剂或枸橼酸铋雷尼替丁加2种抗生素的三联疗法关键词：幽门螺杆菌;中医药;治疗;综述
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发布时间：2021-05-20 - 摘要：<正>睑板腺囊肿为小儿常见的眼部疾病,又称霰粒肿。中医称之为胞生痰核,又名"疣病""睥生痰核",是指胞睑内生硬核,触之不痛,皮色如常的眼病[1]。西医治疗本病以手术刮除为主。但由于小儿的依从性差,手术治疗往往给小儿的心理造成较大的伤害。我们在临床上从小儿体禀少阳的生理特点出发,采用纯中药治疗小儿睑板腺囊肿,收效明显,现将验案介绍如下。关键词：小儿睑板腺囊肿;中医治疗;验案
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发布时间：2021-05-20 - 摘要：<正>重症肌无力（MG）是一种神经-肌肉接头部位乙酰胆碱受体减少而出现传递障碍的自身免疫性疾病。临床以相关骨骼肌易疲劳,经休息和服用胆碱酯酶抑制剂治疗后可部分恢复为特征。西医多采用胆碱酯酶抑制类药物、糖皮质激素、免疫抑制剂、血浆置换法和胸腺切除术进行治疗。笔者在临床中发现中医药治疗MG有显著疗效。近年临床观察数十例MG患者,服中药后均可达到西药停药或减药,MG症状改善或痊愈效果。现整理临床治疗个案与同行分享。关键词：重症肌无力;脾肾双补;验案
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发布时间：2021-05-20 - 摘要：<正>八髎穴是一组临床应用范围较广、使用频率较高的穴位,但因其解剖结构的复杂性,使得临床医师在对八髎穴的定位及针刺操作上存在一定困难。导师胡慧为北京中医药大学东方医院针灸科主任医师、教授,对于八髎穴的临床应用有独到的见解,现将胡教授对于八髎穴的定位、针刺手法、功效主治及临床应用的经验介绍如下。1八髎穴的定位八髎穴是指双侧上髎（BL31）、次髎（BL32）、中髎（BL33）、下髎（BL34）,属于足太阳膀胱经穴,左右关键词：八髎穴;定位;针刺
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发布时间：2021-05-20 - 摘要：<正>《北京中医药大学学报（中医临床版）》是由教育部主管、北京中医药大学主办的中医药学术期刊。主编为中国中医界学术权威王永炎院士。办刊宗旨是继承弘扬中国传统医药文化,宣传中医药临床应用,为中医药教学、科研、医疗服务。主要面向国内外医学院校的师生,各级各类医院的临床医生,以及有关专业的人员等。《北京中医药大学学报（中医临床版）》现已被中文生物医学期刊文献数据库、中国生物医学期刊引文数据库、中国期刊全文数据库、中国学术期刊综合评价数据库、中国核心期刊（遴选）数据库、中国科技论文在线收录。
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发布时间：2021-05-20
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