摘要:Objective To investigate the efficacy and safety of cinobufagin injection on hematuria patients due to bladder cancer. Methods 28 cases were divided into treatment group( n = 12) and control group( n = 16). The patients in control group were treated with regular medicine of hemocoagulase( 2 Unit,intravenous drip,three times a day) and hematopoietic materials such as Vitamin 12,folic acid,and chalybeate. In addition to the therapy for the control group,the patients in the treatment group were bladder intravesically instillated with cinobufagin injection. Then a retrospective study was carried out by comparing the effects of hemostasis,alleviating anemia,TCM patterns,urethral pain,Karnofsky Performance Status( KPS),and adverse effect between the two groups. Results After treatment,66. 60 % of patients in the treatment group showed urinary red blood cells counts decreasing more than 50%,while only 31. 25 % patients in the control group did; 58. 33 % of patients in treatment group showed blood HGB level increasing more than 20 g / L,while 25. 00 % patients in the control group; the doses of analgesic drug decreased by more than 50% were 62. 50% in the treatment group,higher than 10. 00 %in the control group; KPS in the treatment group was significantly higher than that in the control group( P< 0. 05). After symptomatic supportive treatment,the adverse effects including mild gastrointestinal reaction,pain,and fever could be relieved. Conclusion The treatment of combined bladder intravesical instillation of cinobufagin injection with intravenous drip of hemocoagulase would alleviate hematuria due to bladder cancer,attenuate urethral pain and improve the patients’ life quality. It can be one of options for treatment for hematuria patients with bladder cancer.
关键词:bladder cancer hematuria;cinobufagin injection;bladder intravesical instillation
摘要:Objective To observe the correlation of spasm degree,deficiency-excess syndromes and activity of daily life( ADL) in early recovery stage from ischemic stroke. Methods 58 patients with spastic hemiplegia at early recovery stage from ischemic stoke included, were divided into excess syndrome group and non-excess syndrome group. The Modified Ashworth Scale( MAS),TCM syndrome scores and Barthel Index( BI) were used to evaluate the degree of spasm,TCM syndrome and ADL respectively on Day 1 and Day 21. Then the correlation of spasm degree,TCM syndrome and ADL were analyzed. Results On Day 1,the spasm degree had a significant positive correlation with TCM symptom scores with the correlation coefficient of 0. 581( P < 0. 01) in excess syndrome group,and the correlation coefficient was 0. 030( P > 0. 05) in the non-excess group. On Day 21,the spasm degree and ADL showed a significant negative correlation with the correlation coefficient of- 0. 449( P < 0. 05),and the correlation coefficient was- 0. 279( P > 0. 05) in non-excess group. Conclusion At the early recovery stage from ischemic stroke,the spasm degree and TCM symptoms had a more significant correlation in excess syndrome group while ADL had a more significant correlation with spasm degree of hemiplegic spasticity in non-excess syndrome group.
关键词:stroke;deficiency-excess syndromes;spastic hemiplegia;activity of daily living;correlation
摘要:Objective To find out characteristics of TCM patterns and key points of syndromes differentiation of coalworkers’ pneumoconiosis( CWP),so as to guide the clinical practice. Methods The TCM patterns of altogether 99 coalworkers with pneumoconiosis were investigated and analyzed. Results After differentiation of the patterns,TCM physicians identified nine patterns : wind-cold invading the lung,wind-heat invading the lung,exterior cold with lung-heat,phlegm-heat blocking the lung,phlegm-dampness blocking the lung,deficiency of lung qi,deficiency of lung yin,deficiency of spleen qi,and blood stasis. The frequencies of pattern of deficiency of lung qi and pattern of phlegm-heat blocking the lung were higher than other patterns. Using cluster analysis of symptoms,four kinds of patterns were identified: deficiency of lung qi,phlegm-heat blocking the lung,phlegm-dampness blocking the lung,and blood stasis. Conclusion The location of CWP is at the lung,the nature of CWP is the simultaneous occurrence of deficiency and excess syndromes,and the basic pathogenesis of toxic dust blocking the lung runs through the course of CWP with the common cause of toxic dust at the occurance,development and changes of CWP. Furthermore,different patients with the same pattern showed differences in the nature of cold,heat,deficiency and excess.
摘要:Objective To evaluate the clinical efficacy of the method of closed reduction with paper splint external fixation guided by the theory of "paying equal attention to sinew and bone ",combined with Zhenggu Powder,in treatment of distal radius fracture. Methods 198 patients suffered from distal radius fracture were treated with the method of paper splint external fixation combined with Zhenggu Powder. Then the function of wrist joint of patients were evaluated and followed up. Results Except for five patients of Fernandez type 2 failing in reduction underwent inpatient surgery( three got no ideal efficacy and two suffered from fracture displacement in one week),193 patients were all treated with the method of paper splint external fixation combined with Zhenggu Powder. With the average time of external fracture fixation of 30. 3 d( range 27 44 d) and 180 followed up cases( loss of 10 patients) with average time of 3. 9 months( range 2 11 months),the efficacy was satisfactory: the excellent and good efficacy rate of 93. 9 %( 112 /180 excellent,57 /180 good,and 11 /180 poor). Conclusion Paper splint external fixation,an effective elastic fixing way guided by the theory of "paying equal attention to sinew and bone",which was able to maintain fracture stability and allow micromotion of the wrist joint,can promote the recovery of wrist joint function with Zhenggu Powder formulated with Chinese medicinal materials.
关键词:paying equal attention to sinew and bone;radius fractures;fracture fixation
摘要:Objective To explore the clinical efficacy of Chinese medicine,including cupping and Chinese herbal medicament patching on acupoints,combined with Global Initiative for Asthma( GINA)scheme on children with mild to moderate asthma. Methods 126 children with mild to moderate asthma were randomly divided into the control group of 51 cases and the treatment group of 75 cases. Taking inhaled glucocorticoid step-up therapy proposed by GINA as the regular treatment in both groups,additionally,the children of the treatment group were treated with cupping and Chinese herbal medicament patching on acupoints. The children in the two groups were treated for consecutive six months. Results The rate of asthma control and the rise rate of forced expiratory volume in one second( FEV1) in the treatment group were higher significantly than those in the control group. In six months,the condition of the children with asthma improved with the extension of treatment time. Conclusion The safety and effectiveness of combination of traditional Chinese and Western medicines on asthma in children are proved.
关键词:Chinese herbal medicament patching on acupoints;cupping therapy;glucocorticoid;asthma in children
摘要:Objective To compare the effects of acupuncture,moxibustion,and acupuncture with moxibustion on patients with functional menstrual disorders. Methods 57 female undergraduates with functional menstrual disorders were eligible and randomly divided into acupuncture group,moxibustion group and acupuncture with moxibustion group. Acupuncture was applied on Baihui( GV 20),and moxibustion was applied on Guanyuan( CV 4),for continuous three menstrual cycles. The therapeutic effects were evaluated. Results The total efficiency showed no significant difference among the three groups using exact probability test( P > 0. 05),with 89% in acupuncture group,84% in moxibustion group,and95% in acupuncture with moxibustion group. However,the curative rate in acupuncture with moxibustion group was 74%,significantly higher than that in acupuncture group or in moxibustion group using nonparametric test( P = 0. 000 1). And the curative rate in acupuncture with moxibustin group was superior to that in moxibustion group( χ2= 13. 571 4,P = 0. 000 2). Conclusion The therapeutic effects of application of acupuncture on Baihui,moxibustion on Guanyuan,and acupuncture on Baihui with moxibustion on Guanyuan were proved. Undoubtedly,the therapeutic effect of acupuncture with moxibustion was better than that of acupuncture or of moxibustion.
摘要:Objective In accordance with the method and principle of clinical epidemiology,a retrospective survey of 200 patients with chronic glomerulonephritis was carried out to study the rules of TCM patterns,ao as to discover the distribution features of asthenia of healthy qi and sthenia of pathogenic factors. By using the factor analysis to analyze and summarize the distribution rules of TCM patterns,the nature of TCM pattern of chronic glomerulonephritis was explored. Methods The clinical symptoms of the200 patients were recorded by using questionnaire responses. By the method of factor analysis,the common factors which dominated the variables of four diagnosis for chronic glomerulonephrits were extracted,analyzed and interpreted. Results Total 13 common factors were included,with the highest occurrence rate of Factor 10. Factor 10 represented the pattern of damp heat and pattern of blood stasis. Of the deficiency patterns,the incidence rate of pattern of qi deficiency represented by Factor 8 was the highest.Furthermore,the results from the traditional pattern analysis by TCM physicians and the factor analysis by software showed significant difference( P < 0. 01). Conclusion Of the deficiency syndromes,the incidence rate of qi deficiency was the highest. The damp heat pattern and the blood stasis pattern were the most common of the excessive syndromes,which suggested that damp heat and blood stasis be the key pathogenesis. The method of factor analysis,not be equal to traditional pattern differentiation,would separate the TCM patterns well to obtain the independent groups of patterns. The main study results were approved,because the leading three incidence rates of patterns including blood stasis pattern and damp heat pattern.
摘要:Objective To explore the distribution rules of TCM syndromes and pattern elements of atherosclerotic cardiovascular diseases. Methods After searching China National Knowledge Infrastructure( CNKI),Wanfang Data and VIP from 2004 to 2013,the literature of coronary atherosclerotic cardiopathy( CAD) and atherothrombotic cerebral infarction( ATCI) linked to TCM patterns was obtained.From the literature,the raw data quantized were input into computer. Each pattern type was recorded,and from which syndrome elements were extracted. Then the frequency and rate of syndrome type and pattern elements were calculated using SPSS 20. 0 Software. Results Altogether 346 articles were eligible and 64 810 cases were included. The common syndrome types in both CAD and ATCI were qi deficiency and blood stasis,intermingling of phlegm and blood stasis,qi deficiency,blood stasis,obstruction of phlegm-turbidity,and the common pattern elements were phlegm-turbidity,blood stasis,toxic heat,yang hyperactivity,qi deficiency and yin deficiency,but the distributions of syndrome types or pattern elements in CAD or ATCI were significantly different using Chi-square test. The rate of syndrome of qi deficiency and blood stasis in patients with ATCI was higher than those in patients with CAD( P <0. 05),while the rates of syndromes of intermingling of phlegm and blood stasis,qi deficiency,blood stasis,obstruction of phlegm- turbidity in patients with CAD were higher than those in patients with ATCI( P < 0. 05). The rates of blood stasis,qi deficiency and yin deficiency in CAD were higher than those in ATCI( P < 0. 05),and the rates of phlegm-tuibidity,toxic heat and yang hyperactivity in ATCI were higher than those in CAD( P < 0. 05). The pattern elements of qi stagnation,yang deficiency and congealing of cold were only found in patients with CAD,while the pattern element of wind were only in ATCI. Conclusion The differences and similarities of distribution of syndrome types and pattern elements evolved in cardiac and cerebrovascular diseases due to atherosclerosis,can guide the treatment of different diseases with the same method.
关键词:atherosclerosis;cardiovascular disease;cerebral infarction;patterns;review of literature