最新刊期
期 4 ， 2021
- 摘要：ObjectiveTo evaluate the clinical efficacy of Shufeng Wenfei Cough-relieving Formula on cough variant asthma of cold fluid retained in the lung pattern.MethodsSixty patients with cough variant asthma of cold fluid retained in the lung pattern were selected from the Respiratory Cough Expert Outpatient at Dongfang Hospital of Beijing University of Chinese Medicine from December 2018 to December 2019. Thirty patients treated with Shufeng Wenfei Cough-relieving Formula were assigned to the treatment group, while 30 patients treated with Montelukast were assigned to the control group. The clinical efficacy, cough onset time, cough relief time, cough disappearance time, cough relief rate, cough disappearance rate, cough recurrence rate, cough symptom score, cough visual analogue scale (VAS), TCM syndrome score and life quality score were retrospectively analyzed.ResultsThe clinical efficacy was significantly better in the treatment group than in the control group (P<0.05).The cough onset time, cough relief time and cough disappearance time were all significantly shorter in the treatment group than in the control group (P<0.05).The cough relief rate and cough disappearance rate were both significantly higher in the treatment group than in the control group (P<0.05). Cough recurrence rate was lower in the treatment group than in the control group (P<0.05). Cough symptom score, cough visual analogue scale (VAS) and TCM syndrome score were all decreased significantly after treatment in both groups (P<0.05), with a lower score in the treatment group than in the control group (P<0.05). Physical status, mental health status, social function score and total life quality score were all decreased significantly after treatment (P<0.05), with a lower score in the treatment group than in the control group (P<0.05).ConclusionsShufeng Wenfei Cough-relieving Formula has good effect in the treatment of cough variant asthma of cold fluid retained in the lung pattern.关键词：Shufeng Wenfei Cough-relieving Formula;cough variant asthma;pattern of cold fluid retained in the lung;clinical efficacy
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发布时间：2021-08-23 - 摘要：ObjectiveTo observe the clinical efficacy of externally-applied and modified Wumeiwan Formula for pruritus in patients with the maintenance therapy of hemodialysis.MethodsSeventy maintenance hemodialysis patients with pruritus were randomly and equally assigned to the control (n=35) and treatment groups(n=35). There were 32 left in the treatment group and 34 left in the control group, with the withdrawal or drop-out excluded. On the basis of hemodialysis and conventional treatment, calamine lotion was applied to the control group while the modified Wumeiwan Formula was given to the treatment group as the topical treatment. The visual analogue scale, Duo’s pruritus score, Pittsburgh sleep quality index and total effective rate of treatment were evaluated before and after the treatment.ResultsThe score of the visual analogue scale statistically decreased after the treatment in both groups(P<0.05), with a significantly greater difference in the treatment group than in the control group(P<0.05). Duo’s pruritus score significantly decreased after the treatment in both groups(P<0.05), with a significantly greater difference in the treatment group than in the control group(P<0.05). The total score of the Pittsburgh sleep quality index was statistically decreased after the treatment in both groups(P<0.05), with a significantly greater difference in the treatment group than in the control group(P<0.05). As for the clinical efficacy, 8 cases showed remarkable effects, 22 cases were effective and 2 cases were ineffective, with a total effective rate of 93.75% in the treatment group. In the control group, 4 cases had remarkable effects, 21 cases were effective, 9 cases were ineffective, with a total effective rate of 73.53%. Nonparametric test showed that as compared with the control group, the modified Wumeiwan Formula has advantages in clinical effects (Z=-2.279, P=0.023, P<0.05).ConclusionsThe externally applied modified Wumeiwan Formula demonstrates remarkable therapeutic efficacy in relieving pruritus and improving their sleep quality in patients with maintenance hemodialysis.关键词：Wumeiwan Formula;external application;hemodialysis;pruritus;sleep quality
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发布时间：2021-08-23 - 摘要：ObjectiveTo observe the clinical efficacy of externally applied Wenyang Xiaoshui Formula on the Shenque acupoint in patients with malignant ascites of the spleen-kidney yang-deficiency pattern.MethodsForty patients with malignant ascites were randomly assigned to the treatment group (n=20) and control group (n=20). With the withdrawal or drop-out excluded, there were 18 cases left in treatment group and 17 in control group. The control group received basic treatment based on the general conditions of the patients, for instance, nutritional support, albumin supplementation, diuretic and other conventional treatments. Apart from the basis of the treatment that control group received, the treatment group received additional externally applied Wenyang Xiaoshui Formula on the Shenque acupoint. The maximum fluid depth in the abdominal cavity, umbilical horizontal abdominal circumference, urine output in 24 hours, clinical symptom score, Karnofsky (KPS) score, efficacy of ascites regression were observed, and its safety was evaluated.ResultsThe maximum fluid depth in the abdominal cavity, umbilical horizontal abdominal circumference were significantly decreased after treatment in the treatment group(P<0.05), but there were no significant differences in the control group after treatment(P>0.05). There was significant difference between the two groups (P<0.05). The urine output in 24 hours were increased after treatment in the treatment group (P<0.05), but there was no significant difference in the control group after treatment(P>0.05). The urine output in 24 hours was more significantly increased in the treatment group than in the control group after treatment (P<0.05). Clinical symptom scores were significantly decreased after treatment in both groups(P<0.05), more in the treatment group than in the control group after treatment(P<0.05). KPS scores were significantly increased in the treatment group after treatment(P<0.05), but not in the control group after treatment(P>0.05). KPS scores were more significantly increased in treatment group than in the control group after treatment(P<0.05). The efficacy of ascites regression was significantly better in the treatment group than in the control group(P<0.05). The blood routine, liver function, and renal function tests in the two groups were observed, with no significant adverse reactions.ConclusionsThe externally applied Wenyang Xiaoshui Formula on the Shenque acupoint is effective in relieving malignant ascites.关键词：Wenyang Xiaoshui Formula;external application;Shenque acupoint;malignant ascites;external treatment of TCM;clinical research
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发布时间：2021-08-23 - 摘要：ObjectiveTo analyze the medication rules of TCM compound in the treatment of chronic gastritis with the help of Chinese medicine inheritance auxiliary system, and to provide the basis for clinical prescription and new drug development.MethodsCompound patents for chronic gastritis during 2015-2020 were retrieved in the Chinese medicine inheritance auxiliary system(V2.5). The frequency of traditional Chinese medicine, the meridians of traditional Chinese medicine and the flavor of medicinal herbs were counted, the rules of traditional Chinese medicine compound patents were analyzed by using the method of association rules.Core drug combinations were extracted based on complex system entropy clustering, and candidate new prescriptions were obtained by unsupervised entropy hierarchical clustering.ResultsA total of 126 TCM prescriptions for the treatment of chronic gastritis were included, involving 157 medicinals, and 21 medicinals with frequency≥20.Most frequently used medicinals were Radix Paeoniae Alba(white peony root), Rhizoma Coptidis(coptis rhizome), Rhizoma Atractylodis Macrocephalae(white atractylodes rhizome), Radix Aucklandiae(common aucklandia root), Fructus Aurantii (bitter orange), Pericarpium Citri Reticulatae(aged tangerine peel)and so on.Those medicinals were mainly attributive to the Spleen, Stomach and Liver meridians.Those medicinals were warm and cold in nature, and bitter, pungent and sweet in flavor.The commonly used paired medicinals were Radix Paeoniae Alba(white peony root)and Rhizoma Atractylodis Macrocephalae(white atractylodes rhizome), Rhizoma Corydalis(corydalis rhizome) and Radix Aucklandiae(common aucklandia root), Radix Paeoniae Alba(white peony root) and Radix Aucklandiae(common aucklandia root), Radix Paeoniae Alba(white peony root) and Radix Aucklandiae(common aucklandia root), etc. And the commonly-used three-medicinal combinations were white atractylodes rhizome, white peony root and common aucklandia root, white atractylodes rhizome, white peony root and villous amomum fruit, white atractylodes rhizome, villous amomum fruit and bitter orange. Based on association rules, 15 groups of high-frequency herb combinations were revealed, for instance, "Corydalis corydalis→Fructus Aurantii→ Atractylodes" , "Amomum kernel→Poria cocos→Atractylodes" , "Paeoniae peony→Amoy kernels→Atractylodes" and "Amoy kernels→Fructus Aurantii→Atractylodes" .Twenty-four groups of core TCM combinations were obtained based on complex system entropy clustering.And 12 new prescriptions were mined based on unsupervised entropy hierarchical clustering analysis.ConclusionsTCM is flexible in the treatment of chronic gastritis. The core TCM combination and new candidate prescriptions involve regulating qi and invigorating the spleen, transforming dampness and harmonizing the stomach, promoting blood circulation and relieving pain, transforming food and protecting the stomach, etc.关键词：chronic gastritis;medication rule;Chinese medicine compound patent;data mining
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发布时间：2021-08-23 - 摘要：Narrative medicine is a new practice form of medical humanities. On the basis of "nature and man united in virtue" , traditional Chinese medicine humanities always emphasize the professional ethics requirements of "medicine is benevolence" and "the spirit of great physician" , and also pay attention to patients’ personality, psychology, social factors and their own feelings. Therefore, traditional Chinese medicine and medical humanistic narrative medicine have a natural affinity. Based on previous research, the research team proposed the narrative medical practice mode of "reading, listening, telling and writing stories" . From January to April 2018, 23 medical staff from the Department of Traditional Chinese Medicine, Department of Dermatology of Integrated Chinese and Western Medicine, and Department of Rehabilitation of Integrated Chinese and Western Medicine at the Rongcheng County People’s Hospital of the Xiong’an New Area took narrative medicine practice as the main body through learning and practicing narrative medicine knowledge, narrative reading, narrative dialogue, parallel medical records writing and other methods. Researchers in the process of practice to the doctor for qualitative and quantitative evaluation, narrative medical clinical practice helped to improve the narrative ability of medical workers, helped to improve the relationship between doctors and patients, colleagues, self, which was helpful for clinical diagnosis and treatment of doctor-patient communication. Doctors have improved their ability to balance interpersonal and other conflicts and deal with complex problems in the clinical work. Practical characteristics included strong narrative characteristics of traditional Chinese medicine, caring for the doctors’ multiple social relations, finding the positive side behind the pain, respecting the doctors’ professional authority without losing the temperature and so on.关键词：narrative medicine;parallel chart;narrative reading;narrative dialogue;medical humanistic practice
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发布时间：2021-08-23 - 摘要：Iron deficiency anemia (IDA) is the most common type of anemia in the elderly. The main reasons for IDA are insufficient intake of iron, absorption disorder and an excessive loss. Early intervention for the above causes can prevent the occurrence and progress of IDA in the elderly to a certain extent. Funded by the National Administration of Traditional Chinese Medicine project of "Practical Guidelines for Treatment of Pre-treatment in Traditional Chinese Medicine: Seniors at High Risk of Iron Deficiency Anemia" , through pre-clinical investigations, repeated discussions and demonstrations of experts, a community TCM expert consensus for the elderly at high risk of IDA has been formed. The expert consensus has determined the definition of IDA high-risk groups for the elderly, and the issues related to IDA for the elderly have been discussed in detail in terms of background, definition, screening, diagnosis, management, prevention, and treatment. The introduction of the consensus will improve the social and medical concerns in IDA elders and the elderly with high risk, cultivate self-assessment and prevention awareness of the elderly, strengthen standardized testing behaviors at community medical points, and improve the prevention and treatment level of traditional Chinese medicine in IDA communities for the elderly, thereby improving the health of the elderly and improving the quality of life.关键词：iron-deficiency anemia (IDA);the elderly population;high-risk population;community;prevention and treatment in traditional Chinese medicine
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发布时间：2021-08-23 - 摘要：Cancerous ulcers are commonly severe skin manifestations in patients with advanced tumors. It has tumor cell infiltrations, complicated infections due to ulcer surfaces, often accompanied by ulceration, exudation, oozing and malodor. Professor Wang Pei believes that cancerous ulcers are caused by the cancer poison speficic to the tumor, and the external treatment should focus on eliminating the toxin of the exterior. After cancer toxin is eliminated, flesh-generating and ulcer-constraining medicinal can be immediately applied to promote wound recovery. In terms of treatment, priority is given to the removal of toxins and sores and in terms of ingredients, medicinals with anticancer effects were used. When the ulcer surface is cleared, treatment is focused on tonifying qi and blood, and generating fleshes. Medicinals that can tonify the spleen and kidneys, tonify qi and blood are prescribed. Combined with the clinical cases, Prof.Wang’s experience in treating cancerous ulcers is presented in this article.关键词：cancer ulcers;debridement;myogenic;famous physician’s experience;WANG Pei
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发布时间：2021-08-23 - 摘要：The optic nerve disease is one of the most common eye diseases in the field of neuro-ophthalmic diseases, which can lead to severe visual impairment and even blindness. Professor Wei Qiping has been engaged in ophthalmology for more than 40 years, and has rich clinical experience in the diagnosis and treatment of optic nerve diseases. Professor Wei believes that the treatment of optic nerve diseases should be based on regulating the liver. This paper introduces Professor Wei’s experience in treating optic neuritis, Leber’s hereditary optic neuropathy, ischemic optic neuropathy and optic atrophy from the perspective of the liver, and expounds it in combination with clinical cases.关键词：optic nerve diseases;treating from the liver;famous doctor’s experience;Wei Qiping
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发布时间：2021-08-23 - 摘要：Childhood Tourette’s syndrome is a neuro-psychiatric illness in children. Prof.Wang Sumei has extensive clinical experience in the treatment of this disease and she has proposed a multiple differentiation system of eight-principle syndrome differentiation, etiology syndrome differentiation, zang-fu organ syndrome differentiation, Three-jiao(triple energizers)syndrome differentiation and qi-blood-body fluid syndrome differentiation in treating Tourette’s syndrome.This paper introduces Prof.Wang’s experience in multiple differentiation and treatment of childhood Tourette’s syndrome from the following aspects: eight-principle syndrome differentiation to simplify it, etiology syndrome differentiation to identify the source, syndrome differentiation of zang-fu organs with priority to the liver and spleen, syndrome differentiation of the triple energizers, syndrome differentiation of qi-blood-body fluid with a special approach.关键词：Tourette’s syndrome;multiple differentiation;medical experience;Wang Sumei
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发布时间：2021-08-23 - 摘要：ObjectiveTo observe the effects of Tiaozhi Tongmai Jiedu Formula on the neurological deficit, the infarction volume and the expression levels of Toll-like receptor 4(TLR4) and nuclear factor κB p65(NF-κB p65)in rats with cerebral infarction, and to explore the possible mechanism underlying it.MethodsSixty male SPF rats were randomly assigned to the sham operation group, model group, low-, medium- and high-dose Tiaozhi Tongmai Jiedu Formula groups(n=12 in each group). Except the sham operation group, left middle cerebral artery occlusion (MCAO)was used to establish the model of cerebral infarction in all the other groups. The administration groups were given Tiaozhi Tongmai Jiedu Formula with corresponding doses by intragastric gavage. The sham operation group and model group were gavaged with normal saline. The neurological deficits of rats in each group were recorded. The cerebral infarction volume was measured 2 weeks after intragastric gavage and the expression levels of TLR4 and NF-κB p65 in cortical tissue of the ischemic side were determined.ResultsAs compared with the model group, the neurological deficit scores were all decreased in the low-, medium- and high-dose Tiaozhi Tongmai Jiedu Formula groups (P<0.05). As compared with the low-dose group, neurological deficit scores were all decreased in the medium- and high-dose groups (P<0.05). The neurological deficit scores were lower in the high- dose group than in the medium-dose group(P<0.05). As compared with the model group, the percentage of cerebral infarction volume in the low-, medium- and high-dose groups were all decreased(P<0.05). As compared with low- and medium-dose groups, the percentage of cerebral infarction volume was decreased in the high-dose group(P<0.05). As compared with the sham operation group, the expression levels of TLR4 and NF-κB p65 were all increased in the model, low- and medium-dose groups (P<0.05). There was no significant difference in TLR4 expression level between the high-dose group and the sham operation group(P<0.05). As compared with the sham operation group, the expression levels of NF-κB p65 in the model group, low-, medium- and high-dose groups were increased(P<0.05). As compared with the model group, the expression levels of TLR4 and NF-κB p65 in the low-, medium- and high-dose groups were decreased(P<0.05). As compared with low-dose group, TLR4 expression level was decreased in the high-dose group(P<0.05) and the expression levels of NF-κB p65 were decreased in the medium- and high- dose groups(P<0.05). As compared with medium-dose group, the expression levels of TLR4 and NF-κB p65 were decreased in the high-dose group(P<0.05).ConclusionsTiaozhi Tongmai Jiedu Formula can improve the neurological deficit after cerebral infarction, reduce the volume of cerebral infarction and reduce the expression levels of TLR4 and NF-κB p65 in brain tissues of cerebral infarction in rats and alleviate inflammatory injury, which suggests that it may play a protective role in the neurological injury after cerebral infarction by inhibiting inflammatory factors in NF-κB pathways.关键词：Tiaozhi Tongmai Jiedu Formula;cerebral infarction;neurological deficit;cerebral infarction volume;Toll-like receptor 4(TLR4);nuclear factor κB p65(NF-κB p65);rats
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发布时间：2021-08-23 - 摘要：ObjectiveTo summarize the research status and development trend in the field of famous and veteran Chinese medical physicians.MethodsThe literature collected from CNKI from January 2000 to May 2020 in the research field of senior TCM practitioners were selected as the research object. The information of institutions, authors and keywords of the included literature were analyzed by CiteSpace software.ResultsA total of 2, 396 papers were included, and research status of the famous and veteran Chinese medicine was divided into four stages: initial stage, development stage, peak stage and decline stage. The main publishing institutions included Beijing university of Chinese medicine, Guang’anmen Hospital of China academy of Chinese Medical Sciences, Henan university of traditional Chinese Medicine, Nanjing University of traditional Chinese medicine, Heilongjiang University of traditional Chinese medicine, etc. Three core author cooperation networks were formed, namely Li Jiansheng, Li Qinglei, Ma Jindi, Sun Shuming, Cai Yongmin from Henan University of traditional Chinese Medicine, Zhang Runshun, Liu Baoyan, Wang Yinghui, Yao Naili from China Academy of Chinese Medical Sciences, and Wang Qingqi, Chen Min, Huang Yao from Shanghai University of Chinese Medicine. Cluster analysis was conducted on the keywords, and 9 categories were obtained, including syndrome differentiation and treatment, the famous and veteran Chinese medicine, data mining, clinical experience, and heritage education. The evolution of research hotspots and the analysis of research frontiers showed that clinical experience, academic experience, syndrome differentiation and treatment were the basis of research, and there were gradually emerging research hotspots such as famous and veteran Chinese medicine experience, data mining, medication rules and association rules. Medication rules and association rules had been the research frontier in the past 8 years, and no new research frontier had emerged in the past 3 years.ConclusionsThe research field of the famous and veteran Chinese medical physicians has developed rapidly in the past 20 years, and a number of high-yielding research teams have been formed. Data mining has been a hot research topic in the past 8 years. It is suggested to integrate more innovative research methods to carry out research.关键词：famous TCM physicians;CiteSpace;knowledge map;visualization;experience inheritance;data mining
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发布时间：2021-08-23 - 摘要：Non-lactation mastitis is a group of chronic non-bacterial inflammatory diseases occurring in the breast, with breast lumps, abscess, sinus tract and fistula as its main manifestations. It relapses and is difficult to heal. According to the three different stages of the disease, namely the initial stage, the purulent stage and the ulceration stage, the internal treatment method of TCM surgery establishes three treatment principles of elimination, supporting and tonification, among which the supporting method is the most representative characteristic therapy. Half-yin and half-yang syndrome is the most common type. In terms of treatment, clearing and elimination are mainly used for yang syndrome and warming method is mainly used for yin syndrome, and supporting method is more appropriate for half-yin and half-yang syndrome. The specific application of the supporting method in non-lactation mastitis is discussed in this article from the perspective of clearing-supporting method to outthrust the pathogens, supporting the interior to bring out the pus and to generate fleshes, in combination with other methods. According to the theory of the supporting method for non-lactation mastitis and based on disease differentiation and syndrome differentiation, the "No. 2 formula" , used for the purulent stage and the ulceration stage, is introduced in terms of its specific drug use in combination with clinical cases.关键词：non-lactating mastitis;Tuofa(supporting method);half-yin and half-yang syndrome
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发布时间：2021-08-23 - 摘要：Idiopathic tinnitus is more prevalent among adults, which can be divided into acute and chronic tinnitus according to the course of disease. Acute tinnitus may be accompanied by hearing loss, ear congestion, auditory hypersensitivity while chronic tinnitus may be accompanied by insomnia, adverse psychological state and so on. Flaming fire of the liver and gallbladder characterizes acute tinnitus. Treatment for this pattern is centered on clearing away the liver and gallbladder and unblocking the auricular orifices, and "Tong’er Formula" in combination with bloodletting therapy at the ear tip or behind the ears should be applied to treat the acute tinnitus. Acupoints around the ear should be treated with fire needles. Insufficiency of kidney essence characterizes chronic tinnitus. The treatment is mainly to tonify the liver and kidney, calm the nerves and to use "Cong’er Formula" , among which acupoints around the ear are also used with fire needles. The etiology and mechanism of idiopathic tinnitus are not known. The relevant factors that may induce or aggravate tinnitus should be explored in detail, and targeted acupuncture treatment should be carried out to improve tinnitus.关键词：idiopathic tinnitus;acupuncture treatment;clinic thoughts
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发布时间：2021-08-23 - 摘要：IgA nephropathy is the most common primary glomerular disease in clinical practice, and recurrence of gross hematuria or microscopic hematuria and proteinuria are the main clinical manifestations of IgA nephropathy.Traditional Chinese medicine classifies it into "kidney wind" , "bloody urine" , "edema" , "urine turbidity" and other categories, and it holds that this disease has the spleen and kidney deficiency as its root cause, and wind, dampness and toxicity as its symptoms and blood stasis runs throughout the whole disease course.This paper explores the pathological mechanism of IgA nephropathy from the perspective of blood stasis and investigates its treatment from invigorating qi and promoting blood circulation, including replenishing qi to activate blood, treating symptoms as well as root causes, clearing heat and cooling blood, removing heat and calming collaterals, promoting blood circulation and disinhibiting water, regulating Sanjiao, removing blood stasis and detoxification, pushing the old and bringing the new. Besides, this paper also introduces the use of medicinals in combination with clinical cases.关键词：IgA nephropathy: blood stasis;traditional Chinese medicine;proven case
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发布时间：2021-08-23 - 摘要：Psoriasis is a common and recurrent chronic inflammatory skin disease. The main advantage of traditional Chinese medicine in the treatment of psoriasis lies in improving the internal environment of the body. This paper details regulating the number of related cells such as keratinocytes, dendritic cells, macrophages, neutrophils, mast cells, natural killer cells, improving the balance between abnormal T lymphocyte subsets, and inhibiting the secretion of serum related inflammatory cytokines. It provides new ideas for the target treatment of psoriasis and guides clinical practice more accurately.关键词：traditional Chinese medicine;psoriasis;cytokines;mechanism;research progress
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发布时间：2021-08-23
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