Objective Exploring into the characteristics of the syndrome of senile minor cognitive injury （MCI） and the relationship between which with neuropsychology

and providing differentiation basis for early intervention of dementia with TCM. Method Patients who suffered from MCI but not meet the diagnosis standard of DSM-IV and NINCDS-ADRD were chosen as observing objects. Folstein MMSE and the newest neuropsychological test battery of Bristol revised by Tian Jinzhou were applied to measured above patients. Then a syndrome differentiation plan of MCI was made out by reference to Differentiation Scale of Vascular Dementia with which the patients’ syndromes were differentiated and their half-quantitative integrals were defined. Result The most common syndrome of MCI was kidney deficiency. The other ones were phlegm obstructing orifices

blood stasis in collaterals

heat-poison in the interior and hyperactivity of liver-yang. There was a negative correlation between syndrome integral and cognitive index score by the relative analysis. 1. There was a remarkable correlation between the syndrome of kidney deficiency and resemblance. 2. There was a remarkable in the extreme correlation between the syndrome of phlegm obstructing orifices and picture-finishing

distinguish index of word-learning

and a notable correlation with instant story-recalling

receptivity and speed of number-copying. 3. There was a remarkable correlation between the syndrome of blood stasis in collaterals and MMSE

delay story-recalling and distinguish index of word-learning

and a notable in the extreme correlation with receptivity. 4. There was a remarkable correlation between the syndrome of heat-poison in the interior and picture-finishing

its age rectify score and receptivity. 5. There was a remarkable correlation between the syndromes of hyperactivity of liver-yang and distinguish index of word-learning

speed of number-copying. Conclusion Among MCI patients

syndromes of kidney deficiency

phlegm obstructing orifices

blood stasis in collaterals

heat-poison in the interior and hyperactivity of liver-yang were common

which had close relationship with cognitive injury. We thought that the syndromes of kidney deficiency

phlegm obstructing orifices

blood stasis in collaterals

heat-poison in the interior and hyperactivity of liver-yang were basic pathologic factors causing cognitive injury as well as objective basis of syndrome differentiation and treatment of MCI patients. TCM can be used to intervene MCI starting with these factors. It will be significance for preventing dementia.