Objective

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To analyze the herbal medication regularities of prestigious traditional Chinese medicine (TCM) doctors in treating chest impediment and heart pain.

Methods

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With the disease "coronary heart disease" in Western medical terms

and the chief complaints including "cardiodynia" and "chest pain" as the keywords

the search was carried out in Prestigious TCM Doctors Inheritance Platform. The time range was from the date of establishment of the database to February 2022. The frequency statistical analysis

association analysis

hierarchical cluster analysis and complex network analysis were conducted with data mining software.

Results

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A total of 604 prescriptions meeting the standard were retrieved

involving 6 TCM patterns

with the most common one being heart blood stasis obstruction. 285 herbal ingredients are involved. The first 6 ones with the highest frequency are Danshen (Radix et Rhizoma Salviae Miltiorrhizae)

Huangqi (Radix Astragali)

Danggui (Radix Angelicae Senensis)

Zhiqiao (Fructus Aurantii)

Baizhu (Rhizoma Atractylodis Macrocephalae)

and Chuanxiong (Rhizoma Chuanxiong). The medicinals are mainly warm and cold in terms of their properties

and the flavors are mainly bitter

acrid and sweet. The most frequently seen meridians entered by the herbs are the liver meridian

the lung meridian and the spleen meridian. As for their functions

the most frequently used are deficiency-supplementing drugs. Association analysis reveals that the drug pairs with the highest support include "Huangqi-Danshen"

"Zhiqiao-Danshen"

and "Baizhu-Danshen" . Cluster analysis was conducted for medicinals with frequency > 30

and three cluster combinations were obtained. The result of the complex network analysis showed that Danshen

Huangqi

Chuanxiong

Danggui

Baizhu

and Zhiqiao were the core nodes.

Conclusion

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The treatment of chest impediment and heart pain by the prestigious TCM doctors focuses primarily on boosting qi

invigorating blood and dissolving stasis

supplemented by removing phlegm

diffusing impediment and relieving pain.