1.北京中医药大学东直门医院 北京 100029
2.北京中医药大学东方医院
杨泽佩,女,在读博士生
# 安超,女,博士,副主任医师,硕士生导师,E-mail:annie_bucm@126.com
收稿:2022-10-13,
纸质出版:2023-07-30
移动端阅览
杨泽佩, 胡凯文, 丁治国, 等. 针刺治疗手足综合征20例临床观察[J]. 现代中医临床, 2023,30(4):49-52,61.
YANG Zepei, HU Kaiwen, DING Zhiguo, et al. Clinical study of acupuncture in the treatment of hand-foot syndrome[J]. Modern Chinese Clinical Medicine, 2023, 30(4): 49-52,61.
杨泽佩, 胡凯文, 丁治国, 等. 针刺治疗手足综合征20例临床观察[J]. 现代中医临床, 2023,30(4):49-52,61. DOI: 10.3969/j.issn.2095-6606.2023.04.010.
YANG Zepei, HU Kaiwen, DING Zhiguo, et al. Clinical study of acupuncture in the treatment of hand-foot syndrome[J]. Modern Chinese Clinical Medicine, 2023, 30(4): 49-52,61. DOI: 10.3969/j.issn.2095-6606.2023.04.010.
目的
2
观察针刺治疗手足综合征(hand-foot syndrome,HFS)的临床疗效。
方法
2
选取HFS患者20例,给予患者教育、穴位针刺(双侧)治疗3周。采用自身前后对照的研究方法,观察治疗前后的HFS疗效和分级、HFS症状评分、生活质量评分和安全性。
结果
2
治疗3周后,20例中治愈2例,有效12例,总有效14例,总有效率为70 %。HFS症状评分治疗后与治疗前比较,麻木感、针刺感、感觉迟钝、烧灼感、疼痛感、红斑、脱屑、色素沉着、肿胀评分均明显下降(
P
<
0.05);EORTC QLQ-C30评分治疗后与治疗前比较,躯体功能、角色功能、情绪功能、社会功能、疲倦、疼痛、食欲减退、总体生命质量维度评分均明显提高(
P
<
0.05)。治疗中未出现严重不良反应。
结论
2
针刺治疗HFS有较好的临床疗效。
Objective
2
To observe the clinical efficacy of acupuncture in the treatment of hand-foot syndrome (HFS).
Methods
2
20 patients with HFS were selected and given patient education and acupuncture (bilateral) for 3 weeks. Their efficacy and grading of HFS
HFS symptom scores
quality of life scores and safety were observed before and after treatment.
Results
2
After 3 weeks of treatment
2 cases were cured
12 cases were effective
and the total effective rate was 70%. After treatment
the scores of numbness
tingling sensation
insensitivity
burning sensation
pain
erythema
desquamation
pigmentation and swelling decreased significantly (
P
<
0.05). As for the EORTC QLQ-C30 score after treatment and before treatment
physical function
role function
emotional function
social function
fatigue
pain
loss of appetite
overall quality of life dimension scores were significantly improved (
P
<
0.05).
Conclusion
2
Acupuncture has a good clinical effect on HFS.
LACOUTURE M E , SIBAUD V , GERBER P A , et al . Prevention and management of dermatological toxicities related to anticancer agents: ESMO clinical practice guidelines [J]. Ann of Oncol , 2021 , 32 ( 2 ): 157 - 170 .
DEGEN A , ALTER M , SCHENCK F , et al . The hand-foot-syndrome associated with medical tumor therapy - classification and management [J]. JDDG , 2010 , 8 ( 9 ): 652 - 661 .
YAP Y S , KWOK L L , SYN N , et al . Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial [J]. JAMA Oncol , 2017 , 3 ( 11 ): 1538 - 1545 .
SUZUKI S , NAWATA S , INADA Y , et al . A cross-sectional survey of methods for controling hand-foot syndrome in patients receiving capecitabine treatment [J]. Mol Clin Oncol , 2018 , 9 ( 4 ): 443 - 448 .
SON H S , LEE W Y , LEE W S , et al . Compliance and effective management of the hand-foot syndrome in colon cancer patients receiving capecitabine as adjuvant chemotherapy [J]. Yonsei Med J , 2009 , 50 ( 6 ): 796 - 802 .
UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES . Common terminology criteria for adverse events (CTCAE) [EB/OL].[ 2022-08-06 ]. https://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf https://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf .
娄彦妮 , 陈信义 , 田爱平 , 等 . 通络活血法外用治疗化疗性手足综合征临床研究 [J]. 辽宁中医药大学学报 , 2013 , 15 ( 4 ): 68 - 70 .
朱孝娟 , 李杰 . 参草手足润肤膏治疗手足综合征随机双盲对照试验临床观察 [J]. 中华中医药杂志 , 2019 , 34 ( 8 ): 3825 - 3828 .
万崇华 , 陈明清 , 张灿珍 , 等 . 癌症患者生命质量测定量表EORTC QLQ-C30中文版评介 [J]. 实用肿瘤杂志 , 2005 , 20 ( 4 ): 353 - 355 .
李中梓 . 医宗必读 [M]. 郭霞珍 , 王志飞 , 袁卫玲 , 等 ,整理. 北京 : 人民卫生出版社 , 2006 : 277 .
李志明 , 李仝 , 胡凯文 , 等 . 加味仙方活命饮防治卡培他滨相关性手足综合征疗效观察 [J]. 辽宁中医药大学学报 , 2020 , 22 ( 5 ): 62 - 66 .
武敏 , 黄传兵 , 王鹏飞 , 等 . 补阳还五汤化裁治疗气虚血瘀型手足综合征 [J]. 中医学报 , 2023 , 38 ( 5 ): 1082 - 1087 .
杨泽佩 , 田桢 , 鲍伟倩 , 等 . 益元通络法针刺治疗手足综合征的临床经验 [J]. 中华中医药杂志 , 2020 , 35 ( 6 ): 2932 - 2935 .
张晟星 , 戚淦 . 经穴释义汇解 [M]. 上海 : 上海翻译出版公司 , 1984 : 308 .
杨继洲 . 针灸大成 [M]. 李勤璞 , 俞晓旸 ,点校. 北京 : 中华书局 , 2017 : 209 .
STAROBOVA H , VETTER I . Pathophysiology of chemotherapy-induced peripheral neuropathy [J/OL]. Front Mol Neurosci , 2017 , 10 : 174 [ 2022-08-06 ]. https://www.frontiersin.org/articles/10.3389/fnmol.2017.00174/full https://www.frontiersin.org/articles/10.3389/fnmol.2017.00174/full .
ZIJLSTRA F J , VANDENBERG-DELANGE I , HUYGEN F J , et al . Anti-inflammatory actions of acupuncture [J]. Mediators Inflamm , 2003 , 12 ( 2 ): 59 - 69 .
LE J J , YI T , QI L , et al . Electroacupuncture regulate hypothalamic-pituitary-adrenal axis and enhance hippocampal serotonin system in a rat model of depression [J/OL]. Neuroscience Letters , 2016 , 615 : 66 - 71 [ 2022-08-06 ]. https://www.sciencedirect.com/science/article/abs/pii/S0304394016300040?via%3Dihub https://www.sciencedirect.com/science/article/abs/pii/S0304394016300040?via%3Dihub .
陈孟 , 邓明 . 针灸联合药物治疗胃肠肿瘤化疗患者胃肠道反应疗效观察 [J]. 现代中西医结合杂志 , 2016 , 25 ( 15 ): 1664 - 1666 .
0
浏览量
666
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621