不同中医体质婴儿湿疹患者脐带血炎性因子表达差异

杨云月; 王文革; 宦绰; 杨玥

doi:10.3969/j.issn.2095-6606.2023.05.002

您当前的位置：

首页 >

文章列表页 >

不同中医体质婴儿湿疹患者脐带血炎性因子表达差异

临床研究 | 更新时间：2023-10-12

- 不同中医体质婴儿湿疹患者脐带血炎性因子表达差异
- Differences in the expression of inflammatory factors in cord blood in infants with eczema with different TCM constitutions
- 现代中医临床 2023年30卷第5期页码：5-9
- 作者机构：
  
  1.北京中医药大学东直门医院　北京　100700
  2.空军军医大学空军特色医学中心儿科
- 作者简介：
  
  杨云月，女，在读硕士生
  # 王文革，女，博士，主任医师，硕士生导师，E-mail：1264516006@qq.com
- 基金信息：
  
  北京市科技计划项目——首都临床特色应用研究(Z181100001718029)
- DOI：10.3969/j.issn.2095-6606.2023.05.002
  中图分类号： R272
- 收稿：2023-02-10，
  
  纸质出版：2023-09-30
- 稿件说明：
移动端阅览
杨云月, 王文革, 宦绰, 等. 不同中医体质婴儿湿疹患者脐带血炎性因子表达差异[J]. 现代中医临床, 2023,30(5):5-9.

YANG Yunyue, WANG Wenge, HUAN Chuo, et al. Differences in the expression of inflammatory factors in cord blood in infants with eczema with different TCM constitutions[J]. Modern Chinese Clinical Medicine, 2023, 30(5): 5-9.
杨云月, 王文革, 宦绰, 等. 不同中医体质婴儿湿疹患者脐带血炎性因子表达差异[J]. 现代中医临床, 2023,30(5):5-9. DOI： 10.3969/j.issn.2095-6606.2023.05.002.

YANG Yunyue, WANG Wenge, HUAN Chuo, et al. Differences in the expression of inflammatory factors in cord blood in infants with eczema with different TCM constitutions[J]. Modern Chinese Clinical Medicine, 2023, 30(5): 5-9. DOI： 10.3969/j.issn.2095-6606.2023.05.002.

摘要

目的

探讨不同中医体质类型婴儿湿疹患儿脐血相关炎症因子的表达差异，为客观化湿疹患儿中医体质辨证提供依据。

方法

选取2020年10月至2021年10月于空军军医大学空军特色医学中心出生的健康足月新生儿为研究对象，出生时采集脐带静脉血，并于出生后24～72 h内进行中医体质辨识。42 d时随访根据湿疹发病情况分为正常组及湿疹组，并记录湿疹EASI评分。进一步使用ELISA试剂盒检测脐血中TNF－α、IL－1β、IL－6、IL－25、IL－31、IL－33水平。

结果

收集正常组45例，湿疹组45例，其中平和质、阴盛质及阳盛质各15例。湿疹组脐血IL－1β、IL－6、IL－31、IL－33、TNF－α水平高于正常组，湿疹组脐血IL－25水平低于正常组。进一步亚组分析表明，湿疹阴盛质组脐血IL－1β、IL－6水平低于湿疹平和质组，脐血IL－31、TNF－α水平高于湿疹平和质组。湿疹阳盛质组脐血IL－31、TNF－α水平高于湿疹平和质组，脐血IL－1β、IL－6水平高于湿疹阴盛质组。Spearman相关性分析显示，中医体质评分与IL－1β(

＝0.272，

＝0.009)、IL－6(

＝0.271，

＝0.010)之间呈正相关关系。

结论

湿疹患儿中医体质和炎性因子具有一定关联，可能成为新生儿体质辨识客观化的基础。

Abstract

Objective

To explore the expression difference of inflammatory factors in cord blood of infants with eczema of different TCM constitution types

so as to provide a basis for objectifying TCM constitution differentiation of children with eczema.

Methods

Healthy full-term newborns born at the Air Force Medical Center

PLA

from October 2020 to October 2021 were selected as subjects. Their cord blood was collected at birth

and TCM constitution identification was conducted on them within 24 - 72 hours after birth. At 42 days of follow-up

the infants were divided into the normal group and the eczema group according to the incidence of eczema

and their EASI scores of eczema were recorded. Further detection of TNF-α

IL-1β

IL-6

IL-25

IL-31 and IL-33 levels in the cord blood was conducted by ELISA kit.

Results

45 children were recruited in the normal group and 45 in the eczema group were collected

including the balanced constitution (

=15)

yin excessiveness constitution (

=15) and yang excessiveness constitution (

=15). The levels of IL-1β

IL-6

IL-31

IL-33 and TNF-α in cord blood in the eczema group were higher than those in normal group

while the level of IL-25 in cord blood in eczema group was lower than that in normal group. Further subgroup analysis of the eczema group showed that the levels of IL-1β and IL-6 in cord blood in those with the yin excessiveness constitution were lower than those of children with the balanced constitution

while the levels of IL-31 and TNF-α were higher than that of gentleness group. The cord blood of IL-31 and TNF-α in the yang excessiveness constitution were higher than that of the balanced constitution

while the levels of IL-1β and IL-6 in cord blood were higher than that of yin excessiveness constitution. Spearman correlation analysis showed that there was a positive correlation between TCM constitution score and IL-1β (

=0.272

=0.009)

IL-6 (

=0.271

=0.010).

Conclusion

The TCM constitutions of children with eczema are related to their levels inflammatory factors

which may be the basis for the objectification of newborn constitution identification.

关键词

Keywords

references

SUN M ， LUO J ， LIU H ， et al . Can mixed strains of lactobacillus and bifidobacterium reduce eczema in infants under three years of age? A Meta-analysis [J]. Nutrients , 2021 , 13 ( 5 ): 1461 .

LI H ， ZHANG Z ， ZHANG H ， et al . Update on the pathogenesis and therapy of atopic dermatitis [J]. Clin Rev Allergy Immunol , 2021 , 61 ( 3 ): 324 - 338 .

FRAZIER W ， BHARDWAJ N . Atopic dermatitis：diagnosis and treatment [J]. Am Fam Physician , 2020 , 101 ( 10 ): 590 - 598 .

YANG L ， FU J ， ZHOU Y . Research progress in atopic march [J]. Front Immunol , 2020 ( 11 ): 1907 .

王琦 . 9种基本中医体质类型的分类及其诊断表述依据 [J]. 北京中医药大学学报 , 2005 , 28 ( 4 ): 1 - 8 .

LI X N ， WU D ， LIU Y ， et al . Prenatal exposure to bisphenols，immune responses in cord blood and infantile eczema：a nested prospective cohort study in China [J]. Ecotoxicol Environ Saf , 2021 ( 228 ): 112987 .

谭汉旭，王文革 . 中医体质分型与婴儿早期湿疹的相关性分析 [J]. 中国中医急症 , 2020 , 29 ( 8 ): 1447 - 1449 .

赵红梅，季聪华，曾友兰，等 . 新生儿中医体质辨识表的编制及信度和效度分析 [J]. 浙江中医药大学学报 , 2015 , 39 ( 12 ): 873 - 877 .

中华医学会皮肤性病学分会免疫学组 . 湿疹诊疗指南(2011年) [J]. 中华皮肤科杂志 , 2011 , 44 ( 1 ): 5 - 6 .

赵辨 . 湿疹面积及严重度指数评分法 [J]. 中华皮肤科杂志 , 2004 , 52 ( 1 ): 7 - 8 .

赵红梅，王晓鸣，辛顺心 . 新生儿体质与病理性黄疸的相关性研究 [J]. 中国中医基础医学杂志 , 2015 , 21 ( 3 ): 312 - 313 .

李根 . 新生儿高胆红素血症与中医体质及危险因素相关性研究 [J]. 河南中医 , 2020 , 40 ( 10 ): 1585 - 1588 .

王济生 . 关于婴幼儿体质的若干理论思考 [J]. 中医儿科杂志 , 2006 , 2 ( 3 ): 7 - 8 .

庄严，王学艳，石海云，等 . 不同年龄湿疹患儿的中医临床体质类型研究 [J]. 中国中医基础医学杂志 , 2011 , 17 ( 5 ): 539 - 541 .

刘卓勋，杨京华，黄振祺 . 岭南地区小儿体质辨证分型初探 [J]. 新中医 , 2014 , 45 ( 5 ): 236 - 238 .

李竹青 . 《王琦九种中医体质量表(0－3岁婴幼儿版)》的编制与评价研究 [D]. 北京：北京中医药大学， 2021 .

MOON G H ， LEE Y ， KIM E K ， et al . Immunomodulatory and anti-inflammatory effects of Asiatic acid in a DNCB-Induced atopic dermatitis animal model [J]. Nutrients , 2021 , 13 ( 7 ): 2448 .

BOROWCZYK J ， SHUTOVA M ， BREMBILLA N C ， et al . IL－25 (IL－17E) in epithelial immunology and pathophysiology [J]. J Allergy Clin Immun , 2021 , 148 ( 1 ): 40 - 52 .

MURDACA G ， GRECO M ， TONACCI A ， et al . IL－33/IL－31 axis in immune-mediated and allergic diseases [J]. Int J Mol Sci , 2019 , 20 ( 23 ): 5856 .

GAMEZ C ， METCALFE J ， PRESCOTT S L ， et al . Lower cord blood IL－17 and IL－25，but not other epithelial Cell-Derived cytokines are associated with atopic dermatitis in infancy [J]. Int Arch Allergy Immunol , 2021 , 182 ( 6 ): 474 - 478 .

杨艺娇，杨玲，倪晓容 . 多囊卵巢综合征中医证型与体质分布及血清炎症因子的相关性研究 [J]. 河北中医 , 2020 , 42 ( 10 ): 1465 - 1470 .

MACHURA E ， SZCZEPAŃSKA M ， MAZUR B ， et al . Interleukin 1－β，interleukin－1 receptor antagonist and vitamin D levels in children with atopic dermatitis [J]. Cent Eur J Immunol , 2018 , 43 ( 2 ): 180 - 185 .

GUTTMAN-YASSKY E ， DIAZ A ， PAVEL A B ， et al . Use of tape strips to detect immune and barrier abnormalities in the skin of children with early-onset atopic dermatitis [J]. JAMA Dermatol , 2019 , 155 ( 12 ): 1358 - 1370 .

浏览量

718

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

益气解毒方对12 Gy60Co γ射线辐射后Sertoli细胞分泌功能的防护作用及机制研究

哮喘与中医体质关联性研究的系统评价与Meta分析*

基于“标本从化”理论的三因司天方临证举隅

基于客主加临之运气禀赋的运气司天方应用

基于“逆流挽舟”法探讨儿童哮喘病机与治疗思路